Serum albumin and liver dysfunction mediate the associations between organophosphorus pesticide exposure and hypertension among US adults
Human health is commonly threatened by organophosphorus pesticides (OPPs) due to their widespread use and biological characteristics. However, the combined effect of mixtures of OPPs metabolites on the risk of hypertension and potential mechanism remain limited. To comprehensively investigate the ef...
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| creator | Dong, Yinqiao Xu, Wei Liu, Shiping Xu, Zhongqing Qiao, Shan Cai, Yong |
| description | Human health is commonly threatened by organophosphorus pesticides (OPPs) due to their widespread use and biological characteristics. However, the combined effect of mixtures of OPPs metabolites on the risk of hypertension and potential mechanism remain limited.
To comprehensively investigate the effects between OPPs exposure on hypertension risk and explore and underlying mechanism among US general population.
This cross-sectional study collected US adults who had available data on urine OPPs metabolites (dialkyl phosphate compounds, DAPs) from the National Health and Nutrition Examination Survey (NHANES) to assess the relationships of DAPs with hypertension risk. Survey-weighted logistic regression, restricted cubic spline (RCS), and mixed exposure analysis models [weighted quantile sum regression (WQS) and Bayesian kernel machine regression (BKMR)] were used to analyze individual, dose-response and combined associations between urinary DAPs metabolites and hypertension risk, respectively. Mediation analysis determined the potential intermediary role of serum albumin and liver function in the above associations.
Compared with the reference group, participants with the highest tertile levels of DEP, DMTP, DETP, and DMDTP experienced increased risk of hypertension by 1.21-fold (95%CI: 1.02–1.36), 1.20-fold (95%CI: 1.02–1.42), 1.19-fold (95%CI: 1.01–1.40), and 1.17-fold (95%CI: 1.03–1.43), respectively. RCS curve also showed positive exposure-response associations of individual DAPs with hypertension risk. WQS and BKMR analysis further confirmed DAP mixtures were significantly associated with increased risk of hypertension, with DEP identified as a major contributor to the combined effect. Mediation analysis indicated that serum albumin and AST/ALT ratios played crucial mediating roles in the relationships between individual and mixed urinary DAPs and the prevalence of hypertension.
Our findings provided more comprehensive and novel perspectives into the individual and combined effects of urinary OPPs matabolites on the increased risk of hypertension and the possible driving mechanism, which would be of great significance for environmental control and early prevention of hypertension.
[Display omitted]
•Exploring the relationship between organophosphorus pesticide metabolites and hypertension•Individual dialkyl phosphate compounds (DAPs) metabolites were associated with hypertension.•Co-exposure of DAPs was positively associated with hypertension risk.•Seru |
| doi_str_mv | 10.1016/j.scitotenv.2024.174748 |
| format | Article |
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To comprehensively investigate the effects between OPPs exposure on hypertension risk and explore and underlying mechanism among US general population.
This cross-sectional study collected US adults who had available data on urine OPPs metabolites (dialkyl phosphate compounds, DAPs) from the National Health and Nutrition Examination Survey (NHANES) to assess the relationships of DAPs with hypertension risk. Survey-weighted logistic regression, restricted cubic spline (RCS), and mixed exposure analysis models [weighted quantile sum regression (WQS) and Bayesian kernel machine regression (BKMR)] were used to analyze individual, dose-response and combined associations between urinary DAPs metabolites and hypertension risk, respectively. Mediation analysis determined the potential intermediary role of serum albumin and liver function in the above associations.
Compared with the reference group, participants with the highest tertile levels of DEP, DMTP, DETP, and DMDTP experienced increased risk of hypertension by 1.21-fold (95%CI: 1.02–1.36), 1.20-fold (95%CI: 1.02–1.42), 1.19-fold (95%CI: 1.01–1.40), and 1.17-fold (95%CI: 1.03–1.43), respectively. RCS curve also showed positive exposure-response associations of individual DAPs with hypertension risk. WQS and BKMR analysis further confirmed DAP mixtures were significantly associated with increased risk of hypertension, with DEP identified as a major contributor to the combined effect. Mediation analysis indicated that serum albumin and AST/ALT ratios played crucial mediating roles in the relationships between individual and mixed urinary DAPs and the prevalence of hypertension.
Our findings provided more comprehensive and novel perspectives into the individual and combined effects of urinary OPPs matabolites on the increased risk of hypertension and the possible driving mechanism, which would be of great significance for environmental control and early prevention of hypertension.
[Display omitted]
•Exploring the relationship between organophosphorus pesticide metabolites and hypertension•Individual dialkyl phosphate compounds (DAPs) metabolites were associated with hypertension.•Co-exposure of DAPs was positively associated with hypertension risk.•Serum albumin and AST/ALT were mediators in the association of DAPs with hypertension.•Novel perspectives were found in a large, representative general population.</description><identifier>ISSN: 0048-9697</identifier><identifier>ISSN: 1879-1026</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2024.174748</identifier><identifier>PMID: 39019272</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Cross-Sectional Studies ; Dialkyl phosphates (DAPs) ; Environmental Exposure - statistics & numerical data ; Environmental Pollutants - urine ; Female ; Humans ; Hypertension ; Hypertension - epidemiology ; Joint effect ; Male ; Mediation analysis ; Middle Aged ; NHANES ; Nutrition Surveys ; Organophosphate insecticides ; Organophosphorus Compounds - urine ; Pesticides ; Serum Albumin - metabolism ; United States - epidemiology</subject><ispartof>The Science of the total environment, 2024-10, Vol.948, p.174748, Article 174748</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c247t-311a920373207bfa6eef48c7d7136cd19da855aed0aca346b22d2514e7a526003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.scitotenv.2024.174748$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39019272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dong, Yinqiao</creatorcontrib><creatorcontrib>Xu, Wei</creatorcontrib><creatorcontrib>Liu, Shiping</creatorcontrib><creatorcontrib>Xu, Zhongqing</creatorcontrib><creatorcontrib>Qiao, Shan</creatorcontrib><creatorcontrib>Cai, Yong</creatorcontrib><title>Serum albumin and liver dysfunction mediate the associations between organophosphorus pesticide exposure and hypertension among US adults</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>Human health is commonly threatened by organophosphorus pesticides (OPPs) due to their widespread use and biological characteristics. However, the combined effect of mixtures of OPPs metabolites on the risk of hypertension and potential mechanism remain limited.
To comprehensively investigate the effects between OPPs exposure on hypertension risk and explore and underlying mechanism among US general population.
This cross-sectional study collected US adults who had available data on urine OPPs metabolites (dialkyl phosphate compounds, DAPs) from the National Health and Nutrition Examination Survey (NHANES) to assess the relationships of DAPs with hypertension risk. Survey-weighted logistic regression, restricted cubic spline (RCS), and mixed exposure analysis models [weighted quantile sum regression (WQS) and Bayesian kernel machine regression (BKMR)] were used to analyze individual, dose-response and combined associations between urinary DAPs metabolites and hypertension risk, respectively. Mediation analysis determined the potential intermediary role of serum albumin and liver function in the above associations.
Compared with the reference group, participants with the highest tertile levels of DEP, DMTP, DETP, and DMDTP experienced increased risk of hypertension by 1.21-fold (95%CI: 1.02–1.36), 1.20-fold (95%CI: 1.02–1.42), 1.19-fold (95%CI: 1.01–1.40), and 1.17-fold (95%CI: 1.03–1.43), respectively. RCS curve also showed positive exposure-response associations of individual DAPs with hypertension risk. WQS and BKMR analysis further confirmed DAP mixtures were significantly associated with increased risk of hypertension, with DEP identified as a major contributor to the combined effect. Mediation analysis indicated that serum albumin and AST/ALT ratios played crucial mediating roles in the relationships between individual and mixed urinary DAPs and the prevalence of hypertension.
Our findings provided more comprehensive and novel perspectives into the individual and combined effects of urinary OPPs matabolites on the increased risk of hypertension and the possible driving mechanism, which would be of great significance for environmental control and early prevention of hypertension.
[Display omitted]
•Exploring the relationship between organophosphorus pesticide metabolites and hypertension•Individual dialkyl phosphate compounds (DAPs) metabolites were associated with hypertension.•Co-exposure of DAPs was positively associated with hypertension risk.•Serum albumin and AST/ALT were mediators in the association of DAPs with hypertension.•Novel perspectives were found in a large, representative general population.</description><subject>Adult</subject><subject>Cross-Sectional Studies</subject><subject>Dialkyl phosphates (DAPs)</subject><subject>Environmental Exposure - statistics & numerical data</subject><subject>Environmental Pollutants - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - epidemiology</subject><subject>Joint effect</subject><subject>Male</subject><subject>Mediation analysis</subject><subject>Middle Aged</subject><subject>NHANES</subject><subject>Nutrition Surveys</subject><subject>Organophosphate insecticides</subject><subject>Organophosphorus Compounds - urine</subject><subject>Pesticides</subject><subject>Serum Albumin - metabolism</subject><subject>United States - epidemiology</subject><issn>0048-9697</issn><issn>1879-1026</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v1DAQtRCILoW_AD5yyeKPJE6OVcVHpUocSs-WY0-6XiV28DgL-xP413i7pVcsWdZYb96beY-QD5xtOePtp_0Wrc8xQzhsBRP1lqta1d0LsuGd6ivORPuSbBiru6pve3VB3iDuWTmq46_JhewZ74USG_LnDtI6UzMN6-wDNcHRyR8gUXfEcQ02-xjoDM6bDDTvgBrEaEtV_pEOkH8BBBrTgwlx2UUsN61IF8DsrXdA4fcScU3wSL07LpDK0HhiNXMMD_T-jhq3ThnfklejmRDePb2X5P7L5x_X36rb719vrq9uKytqlSvJuekFk0oKpobRtABj3VnlFJetdbx3pmsaA44Za2TdDkI40fAalGlEy5i8JB_PvEuKP9cyp549WpgmEyCuqCXrhGRtI_sCVWeoTRExwaiX5GeTjpozfcpB7_VzDvqUgz7nUDrfP4msQ3Hvue-f8QVwdQZAWfXgIZ2IINjidAKbtYv-vyJ_AfoOofs</recordid><startdate>20241020</startdate><enddate>20241020</enddate><creator>Dong, Yinqiao</creator><creator>Xu, Wei</creator><creator>Liu, Shiping</creator><creator>Xu, Zhongqing</creator><creator>Qiao, Shan</creator><creator>Cai, Yong</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20241020</creationdate><title>Serum albumin and liver dysfunction mediate the associations between organophosphorus pesticide exposure and hypertension among US adults</title><author>Dong, Yinqiao ; Xu, Wei ; Liu, Shiping ; Xu, Zhongqing ; Qiao, Shan ; Cai, Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c247t-311a920373207bfa6eef48c7d7136cd19da855aed0aca346b22d2514e7a526003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Cross-Sectional Studies</topic><topic>Dialkyl phosphates (DAPs)</topic><topic>Environmental Exposure - statistics & numerical data</topic><topic>Environmental Pollutants - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - epidemiology</topic><topic>Joint effect</topic><topic>Male</topic><topic>Mediation analysis</topic><topic>Middle Aged</topic><topic>NHANES</topic><topic>Nutrition Surveys</topic><topic>Organophosphate insecticides</topic><topic>Organophosphorus Compounds - urine</topic><topic>Pesticides</topic><topic>Serum Albumin - metabolism</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dong, Yinqiao</creatorcontrib><creatorcontrib>Xu, Wei</creatorcontrib><creatorcontrib>Liu, Shiping</creatorcontrib><creatorcontrib>Xu, Zhongqing</creatorcontrib><creatorcontrib>Qiao, Shan</creatorcontrib><creatorcontrib>Cai, Yong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Science of the total environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong, Yinqiao</au><au>Xu, Wei</au><au>Liu, Shiping</au><au>Xu, Zhongqing</au><au>Qiao, Shan</au><au>Cai, Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum albumin and liver dysfunction mediate the associations between organophosphorus pesticide exposure and hypertension among US adults</atitle><jtitle>The Science of the total environment</jtitle><addtitle>Sci Total Environ</addtitle><date>2024-10-20</date><risdate>2024</risdate><volume>948</volume><spage>174748</spage><pages>174748-</pages><artnum>174748</artnum><issn>0048-9697</issn><issn>1879-1026</issn><eissn>1879-1026</eissn><abstract>Human health is commonly threatened by organophosphorus pesticides (OPPs) due to their widespread use and biological characteristics. However, the combined effect of mixtures of OPPs metabolites on the risk of hypertension and potential mechanism remain limited.
To comprehensively investigate the effects between OPPs exposure on hypertension risk and explore and underlying mechanism among US general population.
This cross-sectional study collected US adults who had available data on urine OPPs metabolites (dialkyl phosphate compounds, DAPs) from the National Health and Nutrition Examination Survey (NHANES) to assess the relationships of DAPs with hypertension risk. Survey-weighted logistic regression, restricted cubic spline (RCS), and mixed exposure analysis models [weighted quantile sum regression (WQS) and Bayesian kernel machine regression (BKMR)] were used to analyze individual, dose-response and combined associations between urinary DAPs metabolites and hypertension risk, respectively. Mediation analysis determined the potential intermediary role of serum albumin and liver function in the above associations.
Compared with the reference group, participants with the highest tertile levels of DEP, DMTP, DETP, and DMDTP experienced increased risk of hypertension by 1.21-fold (95%CI: 1.02–1.36), 1.20-fold (95%CI: 1.02–1.42), 1.19-fold (95%CI: 1.01–1.40), and 1.17-fold (95%CI: 1.03–1.43), respectively. RCS curve also showed positive exposure-response associations of individual DAPs with hypertension risk. WQS and BKMR analysis further confirmed DAP mixtures were significantly associated with increased risk of hypertension, with DEP identified as a major contributor to the combined effect. Mediation analysis indicated that serum albumin and AST/ALT ratios played crucial mediating roles in the relationships between individual and mixed urinary DAPs and the prevalence of hypertension.
Our findings provided more comprehensive and novel perspectives into the individual and combined effects of urinary OPPs matabolites on the increased risk of hypertension and the possible driving mechanism, which would be of great significance for environmental control and early prevention of hypertension.
[Display omitted]
•Exploring the relationship between organophosphorus pesticide metabolites and hypertension•Individual dialkyl phosphate compounds (DAPs) metabolites were associated with hypertension.•Co-exposure of DAPs was positively associated with hypertension risk.•Serum albumin and AST/ALT were mediators in the association of DAPs with hypertension.•Novel perspectives were found in a large, representative general population.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39019272</pmid><doi>10.1016/j.scitotenv.2024.174748</doi></addata></record> |
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| subjects | Adult Cross-Sectional Studies Dialkyl phosphates (DAPs) Environmental Exposure - statistics & numerical data Environmental Pollutants - urine Female Humans Hypertension Hypertension - epidemiology Joint effect Male Mediation analysis Middle Aged NHANES Nutrition Surveys Organophosphate insecticides Organophosphorus Compounds - urine Pesticides Serum Albumin - metabolism United States - epidemiology |
| title | Serum albumin and liver dysfunction mediate the associations between organophosphorus pesticide exposure and hypertension among US adults |
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