Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers

Butyrophilin (BTN) molecules are emerging as key regulators of T cell immunity; however, how they trigger cell-mediated responses is poorly understood. Here, the crystal structure of a gamma-delta T cell antigen receptor (γδTCR) in complex with BTN2A1 revealed that BTN2A1 engages the side of the γδT...

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Veröffentlicht in:	Nature immunology 2024-08, Vol.25 (8), p.1355-1366
Hauptverfasser:	Fulford, Thomas S., Soliman, Caroline, Castle, Rebecca G., Rigau, Marc, Ruan, Zheng, Dolezal, Olan, Seneviratna, Rebecca, Brown, Hamish G., Hanssen, Eric, Hammet, Andrew, Li, Shihan, Redmond, Samuel J., Chung, Amy, Gorman, Michael A., Parker, Michael W., Patel, Onisha, Peat, Thomas S., Newman, Janet, Behren, Andreas, Gherardin, Nicholas A., Godfrey, Dale I., Uldrich, Adam P.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554/2509 631/535/1266 Antigens Antigens, CD - chemistry Antigens, CD - immunology Antigens, CD - metabolism Biomedical and Life Sciences Biomedicine Butyrophilin Butyrophilins - chemistry Butyrophilins - immunology Butyrophilins - metabolism Cell-mediated immunity Crystal structure Crystallography, X-Ray Epitopes Humans Immunology Infectious Diseases Intraepithelial Lymphocytes - immunology Intraepithelial Lymphocytes - metabolism Ligands Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Models, Molecular Protein Binding Protein Multimerization Receptors, Antigen, T-Cell, gamma-delta - immunology Receptors, Antigen, T-Cell, gamma-delta - metabolism Structural analysis T cell receptors T-Lymphocytes - immunology T-Lymphocytes - metabolism
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