Bongkrekic acid alleviates airway inflammation via breaking the mPTP/mtDAMPs/RAGE feedback loop in a steroid-insensitive asthma model

Mitochondrial dysfunction is critical in the pathogenesis of asthma. Mitochondrial permeability transition pore (mPTP) regulates the release of mitochondrial damage-associated molecular patterns (mtDAMPs) to maintain mitochondrial homeostasis. Bongkrekic acid (BKA) is a highly selective inhibitor of...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2024-08, Vol.177, p.117111, Article 117111
Hauptverfasser:	Chen, Ying, Huang, Junwen, Li, Yuemao, Chen, Yaoxin, Gong, Zhaoqian, Xu, Maosheng, Ma, Yanyan, Hu, Dapeng, Peng, Xianru, Xu, Guilin, Cai, Shaoxi, Liu, Laiyu, Zhao, Wenqu, Zhao, Haijin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals asthma Asthma - drug therapy Asthma - metabolism Disease Models, Animal Feedback, Physiological - drug effects Female Humans inflammation Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mitochondria - drug effects Mitochondria - metabolism Mitochondrial Membrane Transport Proteins - metabolism mitochondrial permeability transition pore Mitochondrial Permeability Transition Pore - metabolism mtDAMPs RAGE Receptor for Advanced Glycation End Products - metabolism Signal Transduction - drug effects
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