The synthesis of 1,2,3-triazoles as binders of D-dopachrome tautomerase (D-DT) for the development of dual-targeting inhibitors

Despite recent advances in the treatment of cancer, the issue of therapy resistance remains one of the most significant challenges in the field. In this context, signaling molecules, such as cytokines have emerged as promising targets for drug discovery. Examples of cytokines include macrophage migr...

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Veröffentlicht in:European journal of medicinal chemistry 2024-10, Vol.276, p.116665, Article 116665
Hauptverfasser: Osipyan, Angelina, Bulai, Radu-George, Wu, Zhengyang, de Witte, Jarno, van der Velde, Jesse J.H., Kader, Mohammed, van der Wouden, Petra E., Poelarends, Gerrit J., Dekker, Frank J.
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Sprache:eng
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