A Noble Metal Substitution Leads to B12 Cofactor Mimicry by a Rhodibalamin

In mammals, cobalamin is an essential cofactor that is delivered by a multitude of chaperones in an elaborate trafficking pathway to two client enzymes, methionine synthase and methylmalonyl-CoA mutase (MMUT). Rhodibalamins, the rhodium analogs of cobalamins, have been described as antimetabolites d...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemistry (Easton) 2024-08, Vol.63 (15), p.1955-1962
Hauptverfasser:	Ruetz, Markus, Mascarenhas, Romila, Widner, Florian, Kieninger, Christoph, Koutmos, Markos, Kräutler, Bernhard, Banerjee, Ruma
Format:	Artikel
Sprache:	eng
Schlagworte:	bacterial growth cobalt crystal structure heterolytic cleavage homolytic cleavage humans methionine synthase methylmalonyl-CoA mutase Mycobacterium tuberculosis rhodium vitamin B12
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!