Effectiveness of buccal administration of dexmedetomidine and ketamine combination in paediatric dental sedation: A randomized controlled clinical trial
Pain and anxiety can be considerable obstacles while treating paediatric dental patients. Moderate sedation is needed to treat uncooperative patients. This study aimed to compare the effectiveness of buccal administration of dexmedetomidine-ketamine combination versus dexmedetomidine. Fifty-six unco...
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| Veröffentlicht in: | International journal of paediatric dentistry 2024-07 |
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| container_title | International journal of paediatric dentistry |
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| creator | El-Rouby, Sara H Crystal, Yasmi O Elshafie, Ahmed M Wahba, Nadia A El-Tekeya, Magda M |
| description | Pain and anxiety can be considerable obstacles while treating paediatric dental patients. Moderate sedation is needed to treat uncooperative patients.
This study aimed to compare the effectiveness of buccal administration of dexmedetomidine-ketamine combination versus dexmedetomidine.
Fifty-six uncooperative children were randomly assigned into two groups: Group I received buccal dexmedetomidine (2 μg/kg) and ketamine (2 mg/kg) (DEX-KET), whereas Group II received buccal dexmedetomidine (4 μg/kg) (DEX). The effects of drugs were evaluated based on changes in vital signs, onset and duration of sedation, sedation level, analgesia, ease of treatment and procedural adverse effects.
There were no significant differences in vital signs or sedation onset between the two groups. DEX-KET group showed shorter recovery time than DEX group (p |
| doi_str_mv | 10.1111/ipd.13238 |
| format | Article |
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This study aimed to compare the effectiveness of buccal administration of dexmedetomidine-ketamine combination versus dexmedetomidine.
Fifty-six uncooperative children were randomly assigned into two groups: Group I received buccal dexmedetomidine (2 μg/kg) and ketamine (2 mg/kg) (DEX-KET), whereas Group II received buccal dexmedetomidine (4 μg/kg) (DEX). The effects of drugs were evaluated based on changes in vital signs, onset and duration of sedation, sedation level, analgesia, ease of treatment and procedural adverse effects.
There were no significant differences in vital signs or sedation onset between the two groups. DEX-KET group showed shorter recovery time than DEX group (p < .0001). There were no statistically significant differences between both groups regarding sedation level at optimum sedation and during operative procedure (p = .064, p = .069 respectively). The ease of treatment was significantly better in DEX-KET group than in DEX group (p = .048). Procedural side effects and analgesic effects of the sedative drugs were comparable between both groups.
The combination of dexmedetomidine and ketamine delivered buccally provided a better method of delivering care to uncooperative children with more rapid recovery than dexmedetomidine.</description><identifier>ISSN: 0960-7439</identifier><identifier>ISSN: 1365-263X</identifier><identifier>EISSN: 1365-263X</identifier><identifier>DOI: 10.1111/ipd.13238</identifier><identifier>PMID: 39011758</identifier><language>eng</language><publisher>England</publisher><ispartof>International journal of paediatric dentistry, 2024-07</ispartof><rights>2024 BSPD, IAPD and John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c175t-71edc0d3b372498fa7b6f8114c00a6e839ee103e81f0c93a73eda93ac56fbbd53</cites><orcidid>0000-0003-3197-0205 ; 0000-0001-9210-7726 ; 0009-0007-4685-6567 ; 0009-0005-9661-8650</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39011758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Rouby, Sara H</creatorcontrib><creatorcontrib>Crystal, Yasmi O</creatorcontrib><creatorcontrib>Elshafie, Ahmed M</creatorcontrib><creatorcontrib>Wahba, Nadia A</creatorcontrib><creatorcontrib>El-Tekeya, Magda M</creatorcontrib><title>Effectiveness of buccal administration of dexmedetomidine and ketamine combination in paediatric dental sedation: A randomized controlled clinical trial</title><title>International journal of paediatric dentistry</title><addtitle>Int J Paediatr Dent</addtitle><description>Pain and anxiety can be considerable obstacles while treating paediatric dental patients. Moderate sedation is needed to treat uncooperative patients.
This study aimed to compare the effectiveness of buccal administration of dexmedetomidine-ketamine combination versus dexmedetomidine.
Fifty-six uncooperative children were randomly assigned into two groups: Group I received buccal dexmedetomidine (2 μg/kg) and ketamine (2 mg/kg) (DEX-KET), whereas Group II received buccal dexmedetomidine (4 μg/kg) (DEX). The effects of drugs were evaluated based on changes in vital signs, onset and duration of sedation, sedation level, analgesia, ease of treatment and procedural adverse effects.
There were no significant differences in vital signs or sedation onset between the two groups. DEX-KET group showed shorter recovery time than DEX group (p < .0001). There were no statistically significant differences between both groups regarding sedation level at optimum sedation and during operative procedure (p = .064, p = .069 respectively). The ease of treatment was significantly better in DEX-KET group than in DEX group (p = .048). Procedural side effects and analgesic effects of the sedative drugs were comparable between both groups.
The combination of dexmedetomidine and ketamine delivered buccally provided a better method of delivering care to uncooperative children with more rapid recovery than dexmedetomidine.</description><issn>0960-7439</issn><issn>1365-263X</issn><issn>1365-263X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9UctOwzAQtBCIlsKBH0A5wiFlHTcvblVVHlIlLiBxixx7LRkSJ9gOAr6Ez8VpC76sVzsz-xhCzinMaXjXupdzyhJWHJApZVkaJxl7OSRTKDOI8wUrJ-TEuVcAmkICx2TCSqA0T4sp-VkrhcLrDzToXNSpqB6E4E3EZauNdt5yrzszFiR-tijRd62W2mDEjYze0PN2TETX1trssNpEPUepubdaBJrxQc-h3FZvomVkAzWofKMMPONt1zTjtwkNx9aBxptTcqR44_BsH2fk-Xb9tLqPN493D6vlJhZhAR_nFKUAyWqWJ4uyUDyvM1VQuhAAPMOClYgUGBZUgSgZz1mYI0SRZqquZcpm5HKn29vufUDnq1Y7gU3DDXaDqxgUlAFAmgTo1Q4qbOecRVX1VrfcflUUqtGIKhhRbY0I2Iu97FCHq_0j_y7PfgEvz4fm</recordid><startdate>20240716</startdate><enddate>20240716</enddate><creator>El-Rouby, Sara H</creator><creator>Crystal, Yasmi O</creator><creator>Elshafie, Ahmed M</creator><creator>Wahba, Nadia A</creator><creator>El-Tekeya, Magda M</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3197-0205</orcidid><orcidid>https://orcid.org/0000-0001-9210-7726</orcidid><orcidid>https://orcid.org/0009-0007-4685-6567</orcidid><orcidid>https://orcid.org/0009-0005-9661-8650</orcidid></search><sort><creationdate>20240716</creationdate><title>Effectiveness of buccal administration of dexmedetomidine and ketamine combination in paediatric dental sedation: A randomized controlled clinical trial</title><author>El-Rouby, Sara H ; Crystal, Yasmi O ; Elshafie, Ahmed M ; Wahba, Nadia A ; El-Tekeya, Magda M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c175t-71edc0d3b372498fa7b6f8114c00a6e839ee103e81f0c93a73eda93ac56fbbd53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Rouby, Sara H</creatorcontrib><creatorcontrib>Crystal, Yasmi O</creatorcontrib><creatorcontrib>Elshafie, Ahmed M</creatorcontrib><creatorcontrib>Wahba, Nadia A</creatorcontrib><creatorcontrib>El-Tekeya, Magda M</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of paediatric dentistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Rouby, Sara H</au><au>Crystal, Yasmi O</au><au>Elshafie, Ahmed M</au><au>Wahba, Nadia A</au><au>El-Tekeya, Magda M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of buccal administration of dexmedetomidine and ketamine combination in paediatric dental sedation: A randomized controlled clinical trial</atitle><jtitle>International journal of paediatric dentistry</jtitle><addtitle>Int J Paediatr Dent</addtitle><date>2024-07-16</date><risdate>2024</risdate><issn>0960-7439</issn><issn>1365-263X</issn><eissn>1365-263X</eissn><abstract>Pain and anxiety can be considerable obstacles while treating paediatric dental patients. Moderate sedation is needed to treat uncooperative patients.
This study aimed to compare the effectiveness of buccal administration of dexmedetomidine-ketamine combination versus dexmedetomidine.
Fifty-six uncooperative children were randomly assigned into two groups: Group I received buccal dexmedetomidine (2 μg/kg) and ketamine (2 mg/kg) (DEX-KET), whereas Group II received buccal dexmedetomidine (4 μg/kg) (DEX). The effects of drugs were evaluated based on changes in vital signs, onset and duration of sedation, sedation level, analgesia, ease of treatment and procedural adverse effects.
There were no significant differences in vital signs or sedation onset between the two groups. DEX-KET group showed shorter recovery time than DEX group (p < .0001). There were no statistically significant differences between both groups regarding sedation level at optimum sedation and during operative procedure (p = .064, p = .069 respectively). The ease of treatment was significantly better in DEX-KET group than in DEX group (p = .048). Procedural side effects and analgesic effects of the sedative drugs were comparable between both groups.
The combination of dexmedetomidine and ketamine delivered buccally provided a better method of delivering care to uncooperative children with more rapid recovery than dexmedetomidine.</abstract><cop>England</cop><pmid>39011758</pmid><doi>10.1111/ipd.13238</doi><orcidid>https://orcid.org/0000-0003-3197-0205</orcidid><orcidid>https://orcid.org/0000-0001-9210-7726</orcidid><orcidid>https://orcid.org/0009-0007-4685-6567</orcidid><orcidid>https://orcid.org/0009-0005-9661-8650</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| title | Effectiveness of buccal administration of dexmedetomidine and ketamine combination in paediatric dental sedation: A randomized controlled clinical trial |
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