Quantitative 3D electron microscopy characterization of mitochondrial structure, mitophagy, and organelle interactions in murine atrial fibrillation

[Display omitted] •We developed a novel method for 3D quantification of mitophagy to study mitochondrial dysfunction in atrial fibrillation.•Atrial cardiomyocytes in AF showed larger, elongated mitochondria.•Mitochondria in AF cardiomyocytes make 5X greater contact with sarcoplasmic reticulum and 4X...

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Veröffentlicht in:	Journal of structural biology 2024-09, Vol.216 (3), p.108110, Article 108110
Hauptverfasser:	Guttipatti, Pavithran, Saadallah, Najla, Ji, Ruiping, Avula, Uma Mahesh R., Goulbourne, Christopher N., Wan, Elaine Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	3D structure Animals Atrial fibrillation Atrial Fibrillation - metabolism Atrial Fibrillation - pathology Disease Models, Animal Electron microscopy Imaging, Three-Dimensional - methods Male Mice Microscopy, Electron, Scanning - methods Mitochondria Mitochondria - metabolism Mitochondria - pathology Mitochondria - ultrastructure Mitochondria, Heart - metabolism Mitochondria, Heart - pathology Mitochondria, Heart - ultrastructure Mitophagy Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Myocytes, Cardiac - ultrastructure Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum - pathology Sarcoplasmic Reticulum - ultrastructure
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