Galangin Promotes Tendon Repair Mediated by Tendon-Derived Stem Cells through Activating the TGF-β1/Smad3 Signaling Pathway

Tendon injury is a prevalent orthopedic disease that currently lacks effective treatment. Galangin (GLN) is a vital flavonoid found abundantly in galangal and is known for its natural activity. This study aimed to investigate the GLN-mediated molecular mechanism of tendon-derived stem cells (TDSCs)...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2024/07/13, Vol.72(7), pp.669-675
Hauptverfasser:	Deng, Xiongwei, Li, Qiang, Yuan, Haitao, Hu, Hejun, Fan, Shaoyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Alizarin Alkaline phosphatase Animals Cells, Cultured Collagen Collagen (type I) Decorin Deposition Flavonoids Flavonoids - chemistry Flavonoids - pharmacology Flow cytometry galangin Gene expression Growth factors Molecular modelling Orthopedics Proteins Rats Rats, Sprague-Dawley Signal transduction Signal Transduction - drug effects Smad3 Smad3 protein Smad3 Protein - antagonists & inhibitors Smad3 Protein - metabolism Staining Stem cells Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism Tendon Injuries - drug therapy Tendon Injuries - metabolism tendon injury tendon repair tendon-derived stem cell Tendons Tendons - cytology Tendons - drug effects Tendons - metabolism Transforming Growth Factor beta1 - metabolism transforming growth factor β1 (TGF-β1) Transforming growth factor-b Transforming growth factor-b1
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