Macropinocytosis inhibits alkaliptosis in pancreatic cancer cells through fatty acid uptake

Alkaliptosis, a form of regulated cell death, is characterized by lysosomal dysfunction and intracellular pH alkalinization. The pharmacological induction of alkaliptosis using the small molecule compound JTC801 has emerged as a promising anticancer strategy in various types of cancers, particularly...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Carcinogenesis (New York) 2024-12, Vol.45 (12), p.953-964
Hauptverfasser:	Chen, Fangquan, Tang, Hu, Lin, Junhao, Xiang, Limin, Lu, Yanjiao, Kang, Rui, Tang, Daolin, Liu, Jiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Amiloride - analogs & derivatives Apoptosis - drug effects Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell Line, Tumor Fatty Acids - metabolism Humans Hydrogen-Ion Concentration Lysosomes - drug effects Lysosomes - metabolism Oleic Acid - pharmacology Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pinocytosis - drug effects rac1 GTP-Binding Protein - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!