Exploring the antitumor potential of novel quinoline derivatives via tubulin polymerization inhibition in breast cancer; design, synthesis and molecular docking

A series of quinoline derivatives was designed and synthesized as novel tubulin inhibitors targeting the colchicine binding site. All the rationalized compounds 3a-e, 4a-e, 5a-e, and 6a-e have been chosen for screening their cytotoxic activity against 60 cell lines by NCI. Compounds 3b, 3c, 4c, 5c a...

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Veröffentlicht in:	RSC advances 2024-07, Vol.14 (31), p.22092-22112
Hauptverfasser:	Abdelmegeed, Heba, Abdel Ghany, Lina M A, Youssef, Amira, El-Etrawy, Abd-Allah S, Ryad, Noha
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Anticancer properties Binding sites Cell cycle Chemical synthesis Colchicine Molecular docking Polymerization Quinoline
Online-Zugang:	Volltext
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