Bisphenol A: Epigenetic effects on the male reproductive system and male offspring
Bisphenol A (BPA) is a commonly used organic compound. Over the past decades, many studies have examined the mechanisms of BPA toxicity, with BPA-induced alterations in epigenetic modifications receiving considerable attention. Particularly in the male reproductive system, abnormal alterations in ep...
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| Veröffentlicht in: | Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2024-10, Vol.129, p.108656, Article 108656 |
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| creator | Hong, Zhilin Xu, Yingpei Wu, Jinxiang |
| description | Bisphenol A (BPA) is a commonly used organic compound. Over the past decades, many studies have examined the mechanisms of BPA toxicity, with BPA-induced alterations in epigenetic modifications receiving considerable attention. Particularly in the male reproductive system, abnormal alterations in epigenetic markers can adversely affect reproductive function. Furthermore, these changes in epigenetic markers can be transmitted to offspring through the father. Here, we review the effects of BPA exposure on various epigenetic markers in the male reproductive system, including DNA methylation, histone modifications, and noncoding RNA, as well as associated changes in the male reproductive function. We also reviewed the effects of father's exposure to BPA on offspring epigenetic modification patterns.
•Epigenetic modifications during spermatogenesis and maturation.•Bisphenol A (BPA) exposure on multiple epigenetic modifications in male reproductive system.•The role of BPA in the transgenerational epigenetic effects of male offspring. |
| doi_str_mv | 10.1016/j.reprotox.2024.108656 |
| format | Article |
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Over the past decades, many studies have examined the mechanisms of BPA toxicity, with BPA-induced alterations in epigenetic modifications receiving considerable attention. Particularly in the male reproductive system, abnormal alterations in epigenetic markers can adversely affect reproductive function. Furthermore, these changes in epigenetic markers can be transmitted to offspring through the father. Here, we review the effects of BPA exposure on various epigenetic markers in the male reproductive system, including DNA methylation, histone modifications, and noncoding RNA, as well as associated changes in the male reproductive function. We also reviewed the effects of father's exposure to BPA on offspring epigenetic modification patterns.
•Epigenetic modifications during spermatogenesis and maturation.•Bisphenol A (BPA) exposure on multiple epigenetic modifications in male reproductive system.•The role of BPA in the transgenerational epigenetic effects of male offspring.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39004383</pmid><doi>10.1016/j.reprotox.2024.108656</doi></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Benzhydryl Compounds - toxicity Bisphenol A DNA Methylation - drug effects Endocrine Disruptors - toxicity Epigenesis, Genetic - drug effects Epigenetic Genitalia, Male - drug effects Histone modification Humans Male Methylation Non-coding RNA Paternal Exposure - adverse effects Phenols - toxicity Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - genetics Reproduction - drug effects Sperm |
| title | Bisphenol A: Epigenetic effects on the male reproductive system and male offspring |
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