Vitelliform Lesions Associated with Leptochoroid and Pseudodrusen
To characterize clinical and prognostic implications of leptovitelliform maculopathy (LVM), a distinctive phenotype of vitelliform lesion characterized by the coexistence of subretinal drusenoid deposits (SDDs) and leptochoroid. Retrospective, cohort study. The study compared patients affected by LV...
Gespeichert in:
Veröffentlicht in: | Ophthalmology retina 2024-12, Vol.8 (12), p.1151-1162 |
---|---|
Hauptverfasser: | , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1162 |
---|---|
container_issue | 12 |
container_start_page | 1151 |
container_title | Ophthalmology retina |
container_volume | 8 |
creator | Fragiotta, Serena Parravano, Mariacristina Corradetti, Giulia Bousquet, Elodie Polito, Maria Sole Sacconi, Riccardo Capuano, Vittorio Costanzo, Eliana Tombolini, Beatrice Souied, Eric H. Bandello, Francesco Sadda, SriniVas R. Sarraf, David Querques, Giuseppe |
description | To characterize clinical and prognostic implications of leptovitelliform maculopathy (LVM), a distinctive phenotype of vitelliform lesion characterized by the coexistence of subretinal drusenoid deposits (SDDs) and leptochoroid.
Retrospective, cohort study.
The study compared patients affected by LVM with cohorts displaying a similar phenotypic spectrum. This included patients with acquired vitelliform lesions (AVLs) and those with SDDs alone.
A total of 60 eyes of 60 patients were included, of which 20 eyes had LVM, 20 eyes had AVLs, and the remaining had SDDs. Patients >50 years of age with complete medical records and multimodal imaging for ≥6 months of follow-up, including color fundus photography or MultiColor imaging, OCT, fundus autofluorescence, and OCT angiography were included.
Choroidal vascularity index (CVI); proportion of late-stage complications (macular neovascularization, atrophy).
The AVL subgroup exhibited a significantly higher CVI compared with both LVM (P = 0.001) and SDD subgroups (P < 0.001). The proportion of late-stage complications significantly differed among subgroups (chi-square = 7.5, P = 0.02). Eyes with LVM presented the greatest proportion of complications (55%) after a mean of 29.3 months, whereas the remaining eyes presented a similar proportion of complications, including 20% in the AVL group after 27.6 months and 20% in the SDD group after 36.9 months. Kaplan–Meier estimates of survival demonstrated a significant difference in atrophy development between groups (P < 0.001), with a median survival of 3.9 years for the LVM group and 7.1 years for controls. The presence of LVM correlated with a fourfold increase in the likelihood of developing complications.
Leptovitelliform maculopathy, characterized by the association of vitelliform lesions with SDDs and leptochoroid, represents a distinct clinical phenotype in the broader spectrum of vitelliform lesions. The importance of a clinical distinction for these lesions is crucial due to their higher propensity for faster progression and elevated rate of complications, particularly atrophic conversion.
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. |
doi_str_mv | 10.1016/j.oret.2024.07.003 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3080634924</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2468653024003269</els_id><sourcerecordid>3080634924</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1521-c72bbf24743788480e9efff41524b443b703e10586dcd82990eb915461d3644d3</originalsourceid><addsrcrecordid>eNp9kE1Lw0AQhhdRbKn9Ax4kRy-Jsx_ZbMBLKX5BQQ_qdUl2J3RLk627ieK_N6UqnjzNMPO-LzMPIecUMgpUXm0yH7DPGDCRQZEB8CMyZUKqVOYcjv_0EzKPcQMAVDEpCzglE14CCKbolCxeXY_brWt8aJMVRue7mCxi9MZVPdrkw_Xrcb7rvVn74J1Nqs4mTxEH620YInZn5KSpthHn33VGXm5vnpf36erx7mG5WKWG5oympmB13TBRCF4oJRRgiU3TiHEpaiF4XQBHCrmS1ljFyhKwLmkuJLVcCmH5jFwecnfBvw0Ye926aMbbqw79EDUHBZKLkolRyg5SE3yMARu9C66twqemoPf09Ebv6ek9PQ2FHumNpovv_KFu0f5afliNguuDAMcv3x0GHY3DzqB1AU2vrXf_5X8BeHl_QQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3080634924</pqid></control><display><type>article</type><title>Vitelliform Lesions Associated with Leptochoroid and Pseudodrusen</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Fragiotta, Serena ; Parravano, Mariacristina ; Corradetti, Giulia ; Bousquet, Elodie ; Polito, Maria Sole ; Sacconi, Riccardo ; Capuano, Vittorio ; Costanzo, Eliana ; Tombolini, Beatrice ; Souied, Eric H. ; Bandello, Francesco ; Sadda, SriniVas R. ; Sarraf, David ; Querques, Giuseppe</creator><creatorcontrib>Fragiotta, Serena ; Parravano, Mariacristina ; Corradetti, Giulia ; Bousquet, Elodie ; Polito, Maria Sole ; Sacconi, Riccardo ; Capuano, Vittorio ; Costanzo, Eliana ; Tombolini, Beatrice ; Souied, Eric H. ; Bandello, Francesco ; Sadda, SriniVas R. ; Sarraf, David ; Querques, Giuseppe</creatorcontrib><description>To characterize clinical and prognostic implications of leptovitelliform maculopathy (LVM), a distinctive phenotype of vitelliform lesion characterized by the coexistence of subretinal drusenoid deposits (SDDs) and leptochoroid.
Retrospective, cohort study.
The study compared patients affected by LVM with cohorts displaying a similar phenotypic spectrum. This included patients with acquired vitelliform lesions (AVLs) and those with SDDs alone.
A total of 60 eyes of 60 patients were included, of which 20 eyes had LVM, 20 eyes had AVLs, and the remaining had SDDs. Patients >50 years of age with complete medical records and multimodal imaging for ≥6 months of follow-up, including color fundus photography or MultiColor imaging, OCT, fundus autofluorescence, and OCT angiography were included.
Choroidal vascularity index (CVI); proportion of late-stage complications (macular neovascularization, atrophy).
The AVL subgroup exhibited a significantly higher CVI compared with both LVM (P = 0.001) and SDD subgroups (P < 0.001). The proportion of late-stage complications significantly differed among subgroups (chi-square = 7.5, P = 0.02). Eyes with LVM presented the greatest proportion of complications (55%) after a mean of 29.3 months, whereas the remaining eyes presented a similar proportion of complications, including 20% in the AVL group after 27.6 months and 20% in the SDD group after 36.9 months. Kaplan–Meier estimates of survival demonstrated a significant difference in atrophy development between groups (P < 0.001), with a median survival of 3.9 years for the LVM group and 7.1 years for controls. The presence of LVM correlated with a fourfold increase in the likelihood of developing complications.
Leptovitelliform maculopathy, characterized by the association of vitelliform lesions with SDDs and leptochoroid, represents a distinct clinical phenotype in the broader spectrum of vitelliform lesions. The importance of a clinical distinction for these lesions is crucial due to their higher propensity for faster progression and elevated rate of complications, particularly atrophic conversion.
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</description><identifier>ISSN: 2468-6530</identifier><identifier>EISSN: 2468-6530</identifier><identifier>DOI: 10.1016/j.oret.2024.07.003</identifier><identifier>PMID: 39004281</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Choroid - diagnostic imaging ; Choroid - pathology ; Choroidal vascular index ; Female ; Fluorescein Angiography - methods ; Follow-Up Studies ; Fundus Oculi ; Humans ; Leptochoroid ; Male ; Middle Aged ; Multimodal Imaging ; Prognosis ; Retinal Drusen - diagnosis ; Retinal Drusen - etiology ; Retrospective Studies ; Subretinal drusenoid deposit ; Tomography, Optical Coherence - methods ; Visual Acuity ; Vitelliform lesion ; Vitelliform Macular Dystrophy - complications ; Vitelliform Macular Dystrophy - diagnosis</subject><ispartof>Ophthalmology retina, 2024-12, Vol.8 (12), p.1151-1162</ispartof><rights>2024 American Academy of Ophthalmology</rights><rights>Copyright © 2024 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1521-c72bbf24743788480e9efff41524b443b703e10586dcd82990eb915461d3644d3</cites><orcidid>0000-0002-6214-6270 ; 0000-0002-2924-7280 ; 0000-0001-5926-1385 ; 0000-0003-4018-2702 ; 0009-0001-3111-0515 ; 0000-0002-3292-9581 ; 0000-0003-3778-8834 ; 0000-0003-3238-9682 ; 0000-0002-9916-8895</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39004281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fragiotta, Serena</creatorcontrib><creatorcontrib>Parravano, Mariacristina</creatorcontrib><creatorcontrib>Corradetti, Giulia</creatorcontrib><creatorcontrib>Bousquet, Elodie</creatorcontrib><creatorcontrib>Polito, Maria Sole</creatorcontrib><creatorcontrib>Sacconi, Riccardo</creatorcontrib><creatorcontrib>Capuano, Vittorio</creatorcontrib><creatorcontrib>Costanzo, Eliana</creatorcontrib><creatorcontrib>Tombolini, Beatrice</creatorcontrib><creatorcontrib>Souied, Eric H.</creatorcontrib><creatorcontrib>Bandello, Francesco</creatorcontrib><creatorcontrib>Sadda, SriniVas R.</creatorcontrib><creatorcontrib>Sarraf, David</creatorcontrib><creatorcontrib>Querques, Giuseppe</creatorcontrib><title>Vitelliform Lesions Associated with Leptochoroid and Pseudodrusen</title><title>Ophthalmology retina</title><addtitle>Ophthalmol Retina</addtitle><description>To characterize clinical and prognostic implications of leptovitelliform maculopathy (LVM), a distinctive phenotype of vitelliform lesion characterized by the coexistence of subretinal drusenoid deposits (SDDs) and leptochoroid.
Retrospective, cohort study.
The study compared patients affected by LVM with cohorts displaying a similar phenotypic spectrum. This included patients with acquired vitelliform lesions (AVLs) and those with SDDs alone.
A total of 60 eyes of 60 patients were included, of which 20 eyes had LVM, 20 eyes had AVLs, and the remaining had SDDs. Patients >50 years of age with complete medical records and multimodal imaging for ≥6 months of follow-up, including color fundus photography or MultiColor imaging, OCT, fundus autofluorescence, and OCT angiography were included.
Choroidal vascularity index (CVI); proportion of late-stage complications (macular neovascularization, atrophy).
The AVL subgroup exhibited a significantly higher CVI compared with both LVM (P = 0.001) and SDD subgroups (P < 0.001). The proportion of late-stage complications significantly differed among subgroups (chi-square = 7.5, P = 0.02). Eyes with LVM presented the greatest proportion of complications (55%) after a mean of 29.3 months, whereas the remaining eyes presented a similar proportion of complications, including 20% in the AVL group after 27.6 months and 20% in the SDD group after 36.9 months. Kaplan–Meier estimates of survival demonstrated a significant difference in atrophy development between groups (P < 0.001), with a median survival of 3.9 years for the LVM group and 7.1 years for controls. The presence of LVM correlated with a fourfold increase in the likelihood of developing complications.
Leptovitelliform maculopathy, characterized by the association of vitelliform lesions with SDDs and leptochoroid, represents a distinct clinical phenotype in the broader spectrum of vitelliform lesions. The importance of a clinical distinction for these lesions is crucial due to their higher propensity for faster progression and elevated rate of complications, particularly atrophic conversion.
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Choroid - diagnostic imaging</subject><subject>Choroid - pathology</subject><subject>Choroidal vascular index</subject><subject>Female</subject><subject>Fluorescein Angiography - methods</subject><subject>Follow-Up Studies</subject><subject>Fundus Oculi</subject><subject>Humans</subject><subject>Leptochoroid</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multimodal Imaging</subject><subject>Prognosis</subject><subject>Retinal Drusen - diagnosis</subject><subject>Retinal Drusen - etiology</subject><subject>Retrospective Studies</subject><subject>Subretinal drusenoid deposit</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Visual Acuity</subject><subject>Vitelliform lesion</subject><subject>Vitelliform Macular Dystrophy - complications</subject><subject>Vitelliform Macular Dystrophy - diagnosis</subject><issn>2468-6530</issn><issn>2468-6530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRbKn9Ax4kRy-Jsx_ZbMBLKX5BQQ_qdUl2J3RLk627ieK_N6UqnjzNMPO-LzMPIecUMgpUXm0yH7DPGDCRQZEB8CMyZUKqVOYcjv_0EzKPcQMAVDEpCzglE14CCKbolCxeXY_brWt8aJMVRue7mCxi9MZVPdrkw_Xrcb7rvVn74J1Nqs4mTxEH620YInZn5KSpthHn33VGXm5vnpf36erx7mG5WKWG5oympmB13TBRCF4oJRRgiU3TiHEpaiF4XQBHCrmS1ljFyhKwLmkuJLVcCmH5jFwecnfBvw0Ye926aMbbqw79EDUHBZKLkolRyg5SE3yMARu9C66twqemoPf09Ebv6ek9PQ2FHumNpovv_KFu0f5afliNguuDAMcv3x0GHY3DzqB1AU2vrXf_5X8BeHl_QQ</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Fragiotta, Serena</creator><creator>Parravano, Mariacristina</creator><creator>Corradetti, Giulia</creator><creator>Bousquet, Elodie</creator><creator>Polito, Maria Sole</creator><creator>Sacconi, Riccardo</creator><creator>Capuano, Vittorio</creator><creator>Costanzo, Eliana</creator><creator>Tombolini, Beatrice</creator><creator>Souied, Eric H.</creator><creator>Bandello, Francesco</creator><creator>Sadda, SriniVas R.</creator><creator>Sarraf, David</creator><creator>Querques, Giuseppe</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6214-6270</orcidid><orcidid>https://orcid.org/0000-0002-2924-7280</orcidid><orcidid>https://orcid.org/0000-0001-5926-1385</orcidid><orcidid>https://orcid.org/0000-0003-4018-2702</orcidid><orcidid>https://orcid.org/0009-0001-3111-0515</orcidid><orcidid>https://orcid.org/0000-0002-3292-9581</orcidid><orcidid>https://orcid.org/0000-0003-3778-8834</orcidid><orcidid>https://orcid.org/0000-0003-3238-9682</orcidid><orcidid>https://orcid.org/0000-0002-9916-8895</orcidid></search><sort><creationdate>202412</creationdate><title>Vitelliform Lesions Associated with Leptochoroid and Pseudodrusen</title><author>Fragiotta, Serena ; Parravano, Mariacristina ; Corradetti, Giulia ; Bousquet, Elodie ; Polito, Maria Sole ; Sacconi, Riccardo ; Capuano, Vittorio ; Costanzo, Eliana ; Tombolini, Beatrice ; Souied, Eric H. ; Bandello, Francesco ; Sadda, SriniVas R. ; Sarraf, David ; Querques, Giuseppe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1521-c72bbf24743788480e9efff41524b443b703e10586dcd82990eb915461d3644d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Choroid - diagnostic imaging</topic><topic>Choroid - pathology</topic><topic>Choroidal vascular index</topic><topic>Female</topic><topic>Fluorescein Angiography - methods</topic><topic>Follow-Up Studies</topic><topic>Fundus Oculi</topic><topic>Humans</topic><topic>Leptochoroid</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multimodal Imaging</topic><topic>Prognosis</topic><topic>Retinal Drusen - diagnosis</topic><topic>Retinal Drusen - etiology</topic><topic>Retrospective Studies</topic><topic>Subretinal drusenoid deposit</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Visual Acuity</topic><topic>Vitelliform lesion</topic><topic>Vitelliform Macular Dystrophy - complications</topic><topic>Vitelliform Macular Dystrophy - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fragiotta, Serena</creatorcontrib><creatorcontrib>Parravano, Mariacristina</creatorcontrib><creatorcontrib>Corradetti, Giulia</creatorcontrib><creatorcontrib>Bousquet, Elodie</creatorcontrib><creatorcontrib>Polito, Maria Sole</creatorcontrib><creatorcontrib>Sacconi, Riccardo</creatorcontrib><creatorcontrib>Capuano, Vittorio</creatorcontrib><creatorcontrib>Costanzo, Eliana</creatorcontrib><creatorcontrib>Tombolini, Beatrice</creatorcontrib><creatorcontrib>Souied, Eric H.</creatorcontrib><creatorcontrib>Bandello, Francesco</creatorcontrib><creatorcontrib>Sadda, SriniVas R.</creatorcontrib><creatorcontrib>Sarraf, David</creatorcontrib><creatorcontrib>Querques, Giuseppe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmology retina</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fragiotta, Serena</au><au>Parravano, Mariacristina</au><au>Corradetti, Giulia</au><au>Bousquet, Elodie</au><au>Polito, Maria Sole</au><au>Sacconi, Riccardo</au><au>Capuano, Vittorio</au><au>Costanzo, Eliana</au><au>Tombolini, Beatrice</au><au>Souied, Eric H.</au><au>Bandello, Francesco</au><au>Sadda, SriniVas R.</au><au>Sarraf, David</au><au>Querques, Giuseppe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitelliform Lesions Associated with Leptochoroid and Pseudodrusen</atitle><jtitle>Ophthalmology retina</jtitle><addtitle>Ophthalmol Retina</addtitle><date>2024-12</date><risdate>2024</risdate><volume>8</volume><issue>12</issue><spage>1151</spage><epage>1162</epage><pages>1151-1162</pages><issn>2468-6530</issn><eissn>2468-6530</eissn><abstract>To characterize clinical and prognostic implications of leptovitelliform maculopathy (LVM), a distinctive phenotype of vitelliform lesion characterized by the coexistence of subretinal drusenoid deposits (SDDs) and leptochoroid.
Retrospective, cohort study.
The study compared patients affected by LVM with cohorts displaying a similar phenotypic spectrum. This included patients with acquired vitelliform lesions (AVLs) and those with SDDs alone.
A total of 60 eyes of 60 patients were included, of which 20 eyes had LVM, 20 eyes had AVLs, and the remaining had SDDs. Patients >50 years of age with complete medical records and multimodal imaging for ≥6 months of follow-up, including color fundus photography or MultiColor imaging, OCT, fundus autofluorescence, and OCT angiography were included.
Choroidal vascularity index (CVI); proportion of late-stage complications (macular neovascularization, atrophy).
The AVL subgroup exhibited a significantly higher CVI compared with both LVM (P = 0.001) and SDD subgroups (P < 0.001). The proportion of late-stage complications significantly differed among subgroups (chi-square = 7.5, P = 0.02). Eyes with LVM presented the greatest proportion of complications (55%) after a mean of 29.3 months, whereas the remaining eyes presented a similar proportion of complications, including 20% in the AVL group after 27.6 months and 20% in the SDD group after 36.9 months. Kaplan–Meier estimates of survival demonstrated a significant difference in atrophy development between groups (P < 0.001), with a median survival of 3.9 years for the LVM group and 7.1 years for controls. The presence of LVM correlated with a fourfold increase in the likelihood of developing complications.
Leptovitelliform maculopathy, characterized by the association of vitelliform lesions with SDDs and leptochoroid, represents a distinct clinical phenotype in the broader spectrum of vitelliform lesions. The importance of a clinical distinction for these lesions is crucial due to their higher propensity for faster progression and elevated rate of complications, particularly atrophic conversion.
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39004281</pmid><doi>10.1016/j.oret.2024.07.003</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6214-6270</orcidid><orcidid>https://orcid.org/0000-0002-2924-7280</orcidid><orcidid>https://orcid.org/0000-0001-5926-1385</orcidid><orcidid>https://orcid.org/0000-0003-4018-2702</orcidid><orcidid>https://orcid.org/0009-0001-3111-0515</orcidid><orcidid>https://orcid.org/0000-0002-3292-9581</orcidid><orcidid>https://orcid.org/0000-0003-3778-8834</orcidid><orcidid>https://orcid.org/0000-0003-3238-9682</orcidid><orcidid>https://orcid.org/0000-0002-9916-8895</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 2468-6530 |
ispartof | Ophthalmology retina, 2024-12, Vol.8 (12), p.1151-1162 |
issn | 2468-6530 2468-6530 |
language | eng |
recordid | cdi_proquest_miscellaneous_3080634924 |
source | MEDLINE; Alma/SFX Local Collection |
subjects | Aged Aged, 80 and over Choroid - diagnostic imaging Choroid - pathology Choroidal vascular index Female Fluorescein Angiography - methods Follow-Up Studies Fundus Oculi Humans Leptochoroid Male Middle Aged Multimodal Imaging Prognosis Retinal Drusen - diagnosis Retinal Drusen - etiology Retrospective Studies Subretinal drusenoid deposit Tomography, Optical Coherence - methods Visual Acuity Vitelliform lesion Vitelliform Macular Dystrophy - complications Vitelliform Macular Dystrophy - diagnosis |
title | Vitelliform Lesions Associated with Leptochoroid and Pseudodrusen |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T01%3A41%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vitelliform%20Lesions%20Associated%20with%20Leptochoroid%20and%20Pseudodrusen&rft.jtitle=Ophthalmology%20retina&rft.au=Fragiotta,%20Serena&rft.date=2024-12&rft.volume=8&rft.issue=12&rft.spage=1151&rft.epage=1162&rft.pages=1151-1162&rft.issn=2468-6530&rft.eissn=2468-6530&rft_id=info:doi/10.1016/j.oret.2024.07.003&rft_dat=%3Cproquest_cross%3E3080634924%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3080634924&rft_id=info:pmid/39004281&rft_els_id=S2468653024003269&rfr_iscdi=true |