The Microbiological Characteristics of Acinetobacter Baumannii Associated With Early Mortality in Patients With Bloodstream Infection
Abstract Background Despite rapid deaths resulting from Acinetobacter baumannii bacteremia, the clinical impact of the microbiological characteristics of A baumannii strains on early mortality (EM) is unclear. We aimed to identify the microbiological characteristics of A baumannii strains associated...
Gespeichert in:
| Veröffentlicht in: | Open Forum Infectious Diseases 2024-07, Vol.11 (7), p.ofae348 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 7 |
| container_start_page | ofae348 |
| container_title | Open Forum Infectious Diseases |
| container_volume | 11 |
| creator | Lee, Chan Mi Choi, Yunsang Choi, Seong Jin Moon, Song Mi Kim, Eu Suk Kim, Hong Bin Ham, Sin Young Park, Jeong Su Yeom, Jinki Song, Kyoung-Ho |
| description | Abstract
Background
Despite rapid deaths resulting from Acinetobacter baumannii bacteremia, the clinical impact of the microbiological characteristics of A baumannii strains on early mortality (EM) is unclear. We aimed to identify the microbiological characteristics of A baumannii strains associated with EM.
Methods
Clinical information and isolates from patients with A baumannii bacteremia from January 2015 to December 2021 were collected. EM was defined as death within 3 days of the initial positive blood culture, whereas late mortality meant death within 5–30 days. The microbiological characteristics of A baumannii were analyzed using multilocus sequence typing, polymerase chain reactions, and a Galleria mellonella in vivo infection model.
Results
Among 130 patients, 69 (53.1%) died within 30 days and EM occurred in 38 (55.1% of 30-day deaths). Sequence type 191 (ST191) strain was more prevalent in patients with EM than in 30-day survivors (31.6% vs 6.6%). Regarding virulence genes, bfmS was more frequent (92.1% vs 47.5%), whereas bauA was less frequent (13.2% vs 52.5%) in patients with EM than in 30-day survivors. Higher clinical severity, pneumonia, and ST191 infection were identified as independent risk factors for EM. In the G mellonella infection model, ST191, bfmS+, and bauA– isolates showed higher virulence than non-ST191, bfmS–, and bauA+ isolates, respectively.
Conclusions
ST191 and bfmS were more frequently found in the EM group. ST191 infection was also an independent risk factor for EM and highly virulent in the in vivo model. Tailored infection control measures based on these characteristics are necessary for A baumannii bacteremia management.
We investigated the microbiological characteristics of Acinetobacter baumannii and their impact on early mortality (EM) in bacteremia. ST191 and bfmS+ strains were more frequently observed in EM. The Galleria mellonella model showed the higher virulence of ST191 and bfmS+ strains. |
| doi_str_mv | 10.1093/ofid/ofae348 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_3080633691</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A807442362</galeid><oup_id>10.1093/ofid/ofae348</oup_id><sourcerecordid>A807442362</sourcerecordid><originalsourceid>FETCH-LOGICAL-c315t-cb60c869ca7798923f471f836224bd5aa104c58dbdd5a6273f71b9e80b20751f3</originalsourceid><addsrcrecordid>eNp9kcFO3DAQhqOqqCDg1nPlW3voUjtOYvu4rGhBAsGBqsfIccbsVI69tZ3DPgDvXdMsVU-VpfHM6JvR6P-r6j2jF4wq_iVYHEvQwBv5pjqpeS1XUrXi7T_5cXWe0k9KKWO0pUK9q465orTjrDupnh-3QO7QxDBgcOEJjXZks9VRmwwRU0aTSLBkbdBDDsOfNrnU86S9RyTrlIJBnWEkPzBvyZWObk_uQszaYd4T9ORBZwSf0wJcuhDGlCPoidx4CyZj8GfVkdUuwfnhP62-f7163Fyvbu-_3WzWtyvDWZtXZuiokZ0yWgglVc1tI5iVvKvrZhhbrRltTCvHYSxFVwtuBRsUSDrUVLTM8tPq07J3F8OvGVLuJ0wGnNMewpx6TmXRhXeKFfRiQZ-0gx69DbloUt4IE5rgwWLpryUVTVOXC8rA52WgaJlSBNvvIk467ntG-xez-hez-oNZBf9wOGUeJhj_wq_WFODjAoR59_9VvwHoWaAa</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3080633691</pqid></control><display><type>article</type><title>The Microbiological Characteristics of Acinetobacter Baumannii Associated With Early Mortality in Patients With Bloodstream Infection</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford Journals Open Access Collection</source><source>PubMed Central</source><creator>Lee, Chan Mi ; Choi, Yunsang ; Choi, Seong Jin ; Moon, Song Mi ; Kim, Eu Suk ; Kim, Hong Bin ; Ham, Sin Young ; Park, Jeong Su ; Yeom, Jinki ; Song, Kyoung-Ho</creator><creatorcontrib>Lee, Chan Mi ; Choi, Yunsang ; Choi, Seong Jin ; Moon, Song Mi ; Kim, Eu Suk ; Kim, Hong Bin ; Ham, Sin Young ; Park, Jeong Su ; Yeom, Jinki ; Song, Kyoung-Ho</creatorcontrib><description>Abstract
Background
Despite rapid deaths resulting from Acinetobacter baumannii bacteremia, the clinical impact of the microbiological characteristics of A baumannii strains on early mortality (EM) is unclear. We aimed to identify the microbiological characteristics of A baumannii strains associated with EM.
Methods
Clinical information and isolates from patients with A baumannii bacteremia from January 2015 to December 2021 were collected. EM was defined as death within 3 days of the initial positive blood culture, whereas late mortality meant death within 5–30 days. The microbiological characteristics of A baumannii were analyzed using multilocus sequence typing, polymerase chain reactions, and a Galleria mellonella in vivo infection model.
Results
Among 130 patients, 69 (53.1%) died within 30 days and EM occurred in 38 (55.1% of 30-day deaths). Sequence type 191 (ST191) strain was more prevalent in patients with EM than in 30-day survivors (31.6% vs 6.6%). Regarding virulence genes, bfmS was more frequent (92.1% vs 47.5%), whereas bauA was less frequent (13.2% vs 52.5%) in patients with EM than in 30-day survivors. Higher clinical severity, pneumonia, and ST191 infection were identified as independent risk factors for EM. In the G mellonella infection model, ST191, bfmS+, and bauA– isolates showed higher virulence than non-ST191, bfmS–, and bauA+ isolates, respectively.
Conclusions
ST191 and bfmS were more frequently found in the EM group. ST191 infection was also an independent risk factor for EM and highly virulent in the in vivo model. Tailored infection control measures based on these characteristics are necessary for A baumannii bacteremia management.
We investigated the microbiological characteristics of Acinetobacter baumannii and their impact on early mortality (EM) in bacteremia. ST191 and bfmS+ strains were more frequently observed in EM. The Galleria mellonella model showed the higher virulence of ST191 and bfmS+ strains.</description><identifier>ISSN: 2328-8957</identifier><identifier>EISSN: 2328-8957</identifier><identifier>DOI: 10.1093/ofid/ofae348</identifier><identifier>PMID: 39006316</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Analysis ; Bacterial pneumonia ; Blood ; Medical examination ; Mortality ; Patient outcomes ; Pneumonia ; Risk factors ; South Korea ; Virulence (Microbiology)</subject><ispartof>Open Forum Infectious Diseases, 2024-07, Vol.11 (7), p.ofae348</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. 2024</rights><rights>The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.</rights><rights>COPYRIGHT 2024 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c315t-cb60c869ca7798923f471f836224bd5aa104c58dbdd5a6273f71b9e80b20751f3</cites><orcidid>0000-0002-5332-2658 ; 0000-0002-3842-0524 ; 0000-0001-5149-1362 ; 0000-0001-6262-372X ; 0000-0002-3243-540X ; 0000-0002-0419-3968 ; 0000-0001-7907-0412 ; 0000-0001-7132-0157 ; 0000-0002-4517-3840 ; 0000-0003-1241-4895</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,1604,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39006316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Chan Mi</creatorcontrib><creatorcontrib>Choi, Yunsang</creatorcontrib><creatorcontrib>Choi, Seong Jin</creatorcontrib><creatorcontrib>Moon, Song Mi</creatorcontrib><creatorcontrib>Kim, Eu Suk</creatorcontrib><creatorcontrib>Kim, Hong Bin</creatorcontrib><creatorcontrib>Ham, Sin Young</creatorcontrib><creatorcontrib>Park, Jeong Su</creatorcontrib><creatorcontrib>Yeom, Jinki</creatorcontrib><creatorcontrib>Song, Kyoung-Ho</creatorcontrib><title>The Microbiological Characteristics of Acinetobacter Baumannii Associated With Early Mortality in Patients With Bloodstream Infection</title><title>Open Forum Infectious Diseases</title><addtitle>Open Forum Infect Dis</addtitle><description>Abstract
Background
Despite rapid deaths resulting from Acinetobacter baumannii bacteremia, the clinical impact of the microbiological characteristics of A baumannii strains on early mortality (EM) is unclear. We aimed to identify the microbiological characteristics of A baumannii strains associated with EM.
Methods
Clinical information and isolates from patients with A baumannii bacteremia from January 2015 to December 2021 were collected. EM was defined as death within 3 days of the initial positive blood culture, whereas late mortality meant death within 5–30 days. The microbiological characteristics of A baumannii were analyzed using multilocus sequence typing, polymerase chain reactions, and a Galleria mellonella in vivo infection model.
Results
Among 130 patients, 69 (53.1%) died within 30 days and EM occurred in 38 (55.1% of 30-day deaths). Sequence type 191 (ST191) strain was more prevalent in patients with EM than in 30-day survivors (31.6% vs 6.6%). Regarding virulence genes, bfmS was more frequent (92.1% vs 47.5%), whereas bauA was less frequent (13.2% vs 52.5%) in patients with EM than in 30-day survivors. Higher clinical severity, pneumonia, and ST191 infection were identified as independent risk factors for EM. In the G mellonella infection model, ST191, bfmS+, and bauA– isolates showed higher virulence than non-ST191, bfmS–, and bauA+ isolates, respectively.
Conclusions
ST191 and bfmS were more frequently found in the EM group. ST191 infection was also an independent risk factor for EM and highly virulent in the in vivo model. Tailored infection control measures based on these characteristics are necessary for A baumannii bacteremia management.
We investigated the microbiological characteristics of Acinetobacter baumannii and their impact on early mortality (EM) in bacteremia. ST191 and bfmS+ strains were more frequently observed in EM. The Galleria mellonella model showed the higher virulence of ST191 and bfmS+ strains.</description><subject>Analysis</subject><subject>Bacterial pneumonia</subject><subject>Blood</subject><subject>Medical examination</subject><subject>Mortality</subject><subject>Patient outcomes</subject><subject>Pneumonia</subject><subject>Risk factors</subject><subject>South Korea</subject><subject>Virulence (Microbiology)</subject><issn>2328-8957</issn><issn>2328-8957</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kcFO3DAQhqOqqCDg1nPlW3voUjtOYvu4rGhBAsGBqsfIccbsVI69tZ3DPgDvXdMsVU-VpfHM6JvR6P-r6j2jF4wq_iVYHEvQwBv5pjqpeS1XUrXi7T_5cXWe0k9KKWO0pUK9q465orTjrDupnh-3QO7QxDBgcOEJjXZks9VRmwwRU0aTSLBkbdBDDsOfNrnU86S9RyTrlIJBnWEkPzBvyZWObk_uQszaYd4T9ORBZwSf0wJcuhDGlCPoidx4CyZj8GfVkdUuwfnhP62-f7163Fyvbu-_3WzWtyvDWZtXZuiokZ0yWgglVc1tI5iVvKvrZhhbrRltTCvHYSxFVwtuBRsUSDrUVLTM8tPq07J3F8OvGVLuJ0wGnNMewpx6TmXRhXeKFfRiQZ-0gx69DbloUt4IE5rgwWLpryUVTVOXC8rA52WgaJlSBNvvIk467ntG-xez-hez-oNZBf9wOGUeJhj_wq_WFODjAoR59_9VvwHoWaAa</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Lee, Chan Mi</creator><creator>Choi, Yunsang</creator><creator>Choi, Seong Jin</creator><creator>Moon, Song Mi</creator><creator>Kim, Eu Suk</creator><creator>Kim, Hong Bin</creator><creator>Ham, Sin Young</creator><creator>Park, Jeong Su</creator><creator>Yeom, Jinki</creator><creator>Song, Kyoung-Ho</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5332-2658</orcidid><orcidid>https://orcid.org/0000-0002-3842-0524</orcidid><orcidid>https://orcid.org/0000-0001-5149-1362</orcidid><orcidid>https://orcid.org/0000-0001-6262-372X</orcidid><orcidid>https://orcid.org/0000-0002-3243-540X</orcidid><orcidid>https://orcid.org/0000-0002-0419-3968</orcidid><orcidid>https://orcid.org/0000-0001-7907-0412</orcidid><orcidid>https://orcid.org/0000-0001-7132-0157</orcidid><orcidid>https://orcid.org/0000-0002-4517-3840</orcidid><orcidid>https://orcid.org/0000-0003-1241-4895</orcidid></search><sort><creationdate>202407</creationdate><title>The Microbiological Characteristics of Acinetobacter Baumannii Associated With Early Mortality in Patients With Bloodstream Infection</title><author>Lee, Chan Mi ; Choi, Yunsang ; Choi, Seong Jin ; Moon, Song Mi ; Kim, Eu Suk ; Kim, Hong Bin ; Ham, Sin Young ; Park, Jeong Su ; Yeom, Jinki ; Song, Kyoung-Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-cb60c869ca7798923f471f836224bd5aa104c58dbdd5a6273f71b9e80b20751f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Analysis</topic><topic>Bacterial pneumonia</topic><topic>Blood</topic><topic>Medical examination</topic><topic>Mortality</topic><topic>Patient outcomes</topic><topic>Pneumonia</topic><topic>Risk factors</topic><topic>South Korea</topic><topic>Virulence (Microbiology)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Chan Mi</creatorcontrib><creatorcontrib>Choi, Yunsang</creatorcontrib><creatorcontrib>Choi, Seong Jin</creatorcontrib><creatorcontrib>Moon, Song Mi</creatorcontrib><creatorcontrib>Kim, Eu Suk</creatorcontrib><creatorcontrib>Kim, Hong Bin</creatorcontrib><creatorcontrib>Ham, Sin Young</creatorcontrib><creatorcontrib>Park, Jeong Su</creatorcontrib><creatorcontrib>Yeom, Jinki</creatorcontrib><creatorcontrib>Song, Kyoung-Ho</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><jtitle>Open Forum Infectious Diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Chan Mi</au><au>Choi, Yunsang</au><au>Choi, Seong Jin</au><au>Moon, Song Mi</au><au>Kim, Eu Suk</au><au>Kim, Hong Bin</au><au>Ham, Sin Young</au><au>Park, Jeong Su</au><au>Yeom, Jinki</au><au>Song, Kyoung-Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Microbiological Characteristics of Acinetobacter Baumannii Associated With Early Mortality in Patients With Bloodstream Infection</atitle><jtitle>Open Forum Infectious Diseases</jtitle><addtitle>Open Forum Infect Dis</addtitle><date>2024-07</date><risdate>2024</risdate><volume>11</volume><issue>7</issue><spage>ofae348</spage><pages>ofae348-</pages><issn>2328-8957</issn><eissn>2328-8957</eissn><abstract>Abstract
Background
Despite rapid deaths resulting from Acinetobacter baumannii bacteremia, the clinical impact of the microbiological characteristics of A baumannii strains on early mortality (EM) is unclear. We aimed to identify the microbiological characteristics of A baumannii strains associated with EM.
Methods
Clinical information and isolates from patients with A baumannii bacteremia from January 2015 to December 2021 were collected. EM was defined as death within 3 days of the initial positive blood culture, whereas late mortality meant death within 5–30 days. The microbiological characteristics of A baumannii were analyzed using multilocus sequence typing, polymerase chain reactions, and a Galleria mellonella in vivo infection model.
Results
Among 130 patients, 69 (53.1%) died within 30 days and EM occurred in 38 (55.1% of 30-day deaths). Sequence type 191 (ST191) strain was more prevalent in patients with EM than in 30-day survivors (31.6% vs 6.6%). Regarding virulence genes, bfmS was more frequent (92.1% vs 47.5%), whereas bauA was less frequent (13.2% vs 52.5%) in patients with EM than in 30-day survivors. Higher clinical severity, pneumonia, and ST191 infection were identified as independent risk factors for EM. In the G mellonella infection model, ST191, bfmS+, and bauA– isolates showed higher virulence than non-ST191, bfmS–, and bauA+ isolates, respectively.
Conclusions
ST191 and bfmS were more frequently found in the EM group. ST191 infection was also an independent risk factor for EM and highly virulent in the in vivo model. Tailored infection control measures based on these characteristics are necessary for A baumannii bacteremia management.
We investigated the microbiological characteristics of Acinetobacter baumannii and their impact on early mortality (EM) in bacteremia. ST191 and bfmS+ strains were more frequently observed in EM. The Galleria mellonella model showed the higher virulence of ST191 and bfmS+ strains.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>39006316</pmid><doi>10.1093/ofid/ofae348</doi><orcidid>https://orcid.org/0000-0002-5332-2658</orcidid><orcidid>https://orcid.org/0000-0002-3842-0524</orcidid><orcidid>https://orcid.org/0000-0001-5149-1362</orcidid><orcidid>https://orcid.org/0000-0001-6262-372X</orcidid><orcidid>https://orcid.org/0000-0002-3243-540X</orcidid><orcidid>https://orcid.org/0000-0002-0419-3968</orcidid><orcidid>https://orcid.org/0000-0001-7907-0412</orcidid><orcidid>https://orcid.org/0000-0001-7132-0157</orcidid><orcidid>https://orcid.org/0000-0002-4517-3840</orcidid><orcidid>https://orcid.org/0000-0003-1241-4895</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2328-8957 |
| ispartof | Open Forum Infectious Diseases, 2024-07, Vol.11 (7), p.ofae348 |
| issn | 2328-8957 2328-8957 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3080633691 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford Journals Open Access Collection; PubMed Central |
| subjects | Analysis Bacterial pneumonia Blood Medical examination Mortality Patient outcomes Pneumonia Risk factors South Korea Virulence (Microbiology) |
| title | The Microbiological Characteristics of Acinetobacter Baumannii Associated With Early Mortality in Patients With Bloodstream Infection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T22%3A29%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Microbiological%20Characteristics%20of%20Acinetobacter%20Baumannii%20Associated%20With%20Early%20Mortality%20in%20Patients%20With%20Bloodstream%20Infection&rft.jtitle=Open%20Forum%20Infectious%20Diseases&rft.au=Lee,%20Chan%20Mi&rft.date=2024-07&rft.volume=11&rft.issue=7&rft.spage=ofae348&rft.pages=ofae348-&rft.issn=2328-8957&rft.eissn=2328-8957&rft_id=info:doi/10.1093/ofid/ofae348&rft_dat=%3Cgale_proqu%3EA807442362%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3080633691&rft_id=info:pmid/39006316&rft_galeid=A807442362&rft_oup_id=10.1093/ofid/ofae348&rfr_iscdi=true |