Concomitant sickle cell disease and systemic lupus erythematosus: A single‐center case series
Sickle cell disease (SCD) and systemic lupus erythematosus (SLE) are two uncommon disorders each characterized by multisystemic manifestations. Individuals with SCD exhibit abnormalities in the complement pathway, which may predispose patients to develop autoimmune disorders such as SLE. As many man...
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| Veröffentlicht in: | Pediatric blood & cancer 2024-10, Vol.71 (10), p.e31194-n/a |
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| container_title | Pediatric blood & cancer |
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| creator | Lapite, Ajibike Sánchez, Luisana M. Altaffer, Ana Luiza Rae, Meredith Ramirez, Andrea Ann Muscal, Eyal Yildirim‐Toruner, Cagri Tubman, Venée N. |
| description | Sickle cell disease (SCD) and systemic lupus erythematosus (SLE) are two uncommon disorders each characterized by multisystemic manifestations. Individuals with SCD exhibit abnormalities in the complement pathway, which may predispose patients to develop autoimmune disorders such as SLE. As many manifestations of SLE mimic those of SCD, diagnosis and therapeutic management of SLE in a patient with known SCD may be delayed. In this study, we describe our institutional experience of diagnosing and managing concomitant SCD and SLE. We offer insights into the complex interplay between these conditions to enhance early recognition and effective management of concurrent SCD and SLE. |
| doi_str_mv | 10.1002/pbc.31194 |
| format | Article |
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Individuals with SCD exhibit abnormalities in the complement pathway, which may predispose patients to develop autoimmune disorders such as SLE. As many manifestations of SLE mimic those of SCD, diagnosis and therapeutic management of SLE in a patient with known SCD may be delayed. In this study, we describe our institutional experience of diagnosing and managing concomitant SCD and SLE. We offer insights into the complex interplay between these conditions to enhance early recognition and effective management of concurrent SCD and SLE.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39004780</pmid><doi>10.1002/pbc.31194</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-5973-8507</orcidid><orcidid>https://orcid.org/0000-0003-3138-5671</orcidid><orcidid>https://orcid.org/0000-0002-8530-5131</orcidid></addata></record> |
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| source | MEDLINE; Wiley Journals |
| subjects | Adolescent Anemia, Sickle Cell - complications Autoimmune diseases complement system Disease management Early experience Female Humans Lupus Erythematosus, Systemic - complications Sickle cell disease Systemic lupus erythematosus Young Adult |
| title | Concomitant sickle cell disease and systemic lupus erythematosus: A single‐center case series |
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