The Role of Aging and Senescence in Immune Checkpoint Inhibitor Response and Toxicity
Cellular senescence accumulates with age and has been shown to impact numerous physiological and pathological processes, including immune function. The role of cellular senescence in cancer is multifaceted, but the impact on immune checkpoint inhibitor response and toxicity has not been fully evalua...
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| Veröffentlicht in: | International journal of molecular sciences 2024-07, Vol.25 (13), p.7013 |
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| creator | Jain, Sidharth S Burton Sojo, Giselle Sun, Harry Friedland, Benjamin N McNamara, Megan E Schmidt, Marcel O Wellstein, Anton |
| description | Cellular senescence accumulates with age and has been shown to impact numerous physiological and pathological processes, including immune function. The role of cellular senescence in cancer is multifaceted, but the impact on immune checkpoint inhibitor response and toxicity has not been fully evaluated. In this review, we evaluate the impact of cellular senescence in various biological compartments, including the tumor, the tumor microenvironment, and the immune system, on immune checkpoint inhibitor efficacy and toxicity. We provide an overview of the impact of cellular senescence in normal and pathological contexts and examine recent studies that have connected aging and cellular senescence to immune checkpoint inhibitor treatment in both the pre-clinical and clinical contexts. Overall, senescence plays a multi-faceted, context-specific role and has been shown to modulate immune-related adverse event incidence as well as immune checkpoint inhibitor response. |
| doi_str_mv | 10.3390/ijms25137013 |
| format | Article |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Age Aging Aging - immunology Animals Biomarkers Cancer therapies Cell cycle Cellular Senescence - drug effects Clinical trials DNA damage Hematology Humans Immune Checkpoint Inhibitors - adverse effects Immune Checkpoint Inhibitors - therapeutic use Immune system Metabolism Neoplasms - drug therapy Neoplasms - immunology Neoplasms - pathology Oxidative stress Senescence Toxicity Trends Tumor Microenvironment - drug effects Tumor Microenvironment - immunology Tumorigenesis Wound healing |
| title | The Role of Aging and Senescence in Immune Checkpoint Inhibitor Response and Toxicity |
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