Epidermal Growth Factor Receptor Targeting in Colorectal Carcinoma: Antibodies and Patient-Derived Organoids as a Smart Model to Study Therapy Resistance

Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. Therefore, the need for new therapeutic strategies is still a challenge. Surgery and chemotherapy represent the first-line interventions; nevertheless, the prognosis for metastatic CRC (mCRC) patients remains unac...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of molecular sciences 2024-07, Vol.25 (13), p.7131
Hauptverfasser:	Tardito, Samuele, Matis, Serena, Zocchi, Maria Raffaella, Benelli, Roberto, Poggi, Alessandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antigens Antineoplastic Agents, Immunological - pharmacology Antineoplastic Agents, Immunological - therapeutic use Apoptosis Cancer therapies Cell adhesion & migration Cell growth Cetuximab - pharmacology Cetuximab - therapeutic use Chemotherapy Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Drug resistance Drug Resistance, Neoplasm - drug effects Enzymes Epidermal growth factor ErbB Receptors - antagonists & inhibitors ErbB Receptors - metabolism Humans Immune system Immunotherapy Kinases Ligands Metastasis Molecular Targeted Therapy - methods Mutation Organoids - drug effects Organoids - metabolism Panitumumab - pharmacology Panitumumab - therapeutic use Phosphorylation Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Proteins Radiation therapy Signal Transduction - drug effects Surgery T cell receptors Transcription factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!