Astrocytes facilitate gabazine‐evoked electrophysiological hyperactivity and distinct biochemical responses in mature neuronal cultures

Gamma‐aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the adult brain that binds to GABA receptors and hyperpolarizes the postsynaptic neuron. Gabazine acts as a competitive antagonist to type A GABA receptors (GABAAR), thereby causing diminished neuronal hyperpolarization a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neurochemistry 2024-09, Vol.168 (9), p.3076-3094
Hauptverfasser:	Ahtiainen, Annika, Genocchi, Barbara, Subramaniyam, Narayan Puthanmadam, Tanskanen, Jarno M. A., Rantamäki, Tomi, Hyttinen, Jari A. K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocytes Biochemical analysis Biochemistry Brain co‐culture gabazine gamma‐aminobutyric acid Growth factors Hyperactivity Hyperpolarization Kinases MAP kinase microelectrode array Microelectrodes Neural networks Neurons Neurotrophic factors Phosphorylation Receptors TrkB TrkB receptors Tropomyosin Tyrosine Vascular endothelial growth factor γ-Aminobutyric acid A receptors γ-Aminobutyric acid receptors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!