Macrophage α7nAChR alleviates the inflammation of neonatal necrotizing enterocolitis through mTOR/NLRP3/IL-1β pathway

•Through the detection of α7nAChR, we have identified the involvement of the cholinergic anti-inflammatory pathway (CAP) in NEC for the first time.•This study successfully demonstrated the anti-inflammatory effect of α7nAChR activation in NEC through detailed exploration and validation of clinical s...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	International immunopharmacology 2024-09, Vol.139, p.112590, Article 112590
Hauptverfasser:	Shen, Leiting, Zhong, Xiaohui, Ji, Haosen, Yang, Sisi, Jin, Jingyi, Lyu, Chengjie, Ren, Yichao, Xiao, Yi, Zhang, Yuebai, Fang, Shu, Lin, Nan, Tou, Jinfa, Shu, Qiang, Lai, Dengming
Format:	Artikel
Sprache:	eng
Schlagworte:	IL-1β Macrophage Neonatal necrotizing enterocolitis NLRP3 α7nAChR
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!