Population study of pupillary unrest in ambient light

Population study of pupillary unrest in ambient light

Pupillary unrest in ambient light (PUAL) describes the fluctuation of pupil diameter observed in normal, awake subjects under typical levels of indoor light. PUAL becomes low to absent in young healthy subjects during opioid intoxication. We sought to determine the age-related distribution of PUAL v...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Autonomic neuroscience 2024-08, Vol.254, p.103197, Article 103197
Hauptverfasser: McKay, Rachel Eshima, Kohn, Michael, Schwartz, Elliot, Larson, Merlin D.
Format: Artikel
Sprache:eng
Schlagworte:
Opioid
Pupil
Pupillometry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page 103197
container_title Autonomic neuroscience
container_volume 254
creator McKay, Rachel Eshima
Kohn, Michael
Schwartz, Elliot
Larson, Merlin D.
description Pupillary unrest in ambient light (PUAL) describes the fluctuation of pupil diameter observed in normal, awake subjects under typical levels of indoor light. PUAL becomes low to absent in young healthy subjects during opioid intoxication. We sought to determine the age-related distribution of PUAL values in a random sample of ambulatory participants. Subjects ≥18 years of age were recruited. All were identified by age range (18–29, 30–49, 50–69, and ≥70), and surveyed for diabetes, beta-blocker use, and prior 24-hour opioid use. Relationship between mean PUAL, age group, comorbidity and opioid use were examined by Kruskal Wallis test, and PUAL and was modeled using stepwise multilevel linear regression, including diabetes, beta blocker use, prior 24-hour opioid use, autonomic dysfunction, and pupil diameter as fixed effects and subject as random effect. Among 150 subjects, 17 reported diabetes, 12 reported beta-blocker use, 14 reported prior 24-hour opioid use, and 120 reported no comorbid conditions. PUAL declined in higher age categories (by 0.0307, P 
doi_str_mv 10.1016/j.autneu.2024.103197
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3079855650</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1566070224000511</els_id><sourcerecordid>3079855650</sourcerecordid><originalsourceid>FETCH-LOGICAL-c241t-a000c4b0512ac31618448aa93599949fb97c6acacd449b80965970e4a4e0a34f3</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EoqXwBwhlySZlnPgRb5BQxUuqBAtYW47jgKs0CX4g9e9xlcKS1YxGd-beOQhdYlhiwOxms1Qx9CYuCyhIGpVY8CM0xxUvck4qcpx6ylgOHIoZOvN-AwAVCHaKZmUlBGOUzxF9HcbYqWCHPvMhNrtsaLMxjrbrlNtlsXfGh8z2mdrW1vQh6-zHZzhHJ63qvLk41AV6f7h_Wz3l65fH59XdOtcFwSFXyVGTGigulC4xwxUhlVKipEIIItpacM2UVrohRNT7bFRwMEQRA6okbblA19Pd0Q1fMSWRW-u1Sdl6M0QvS-CiopRRSFIySbUbvHemlaOz2_SDxCD3wORGTsDkHpicgKW1q4NDrLem-Vv6JZQEt5PApD-_rXHS6wRCm8Y6o4NsBvu_ww9z130e</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3079855650</pqid></control><display><type>article</type><title>Population study of pupillary unrest in ambient light</title><source>ScienceDirect Journals (5 years ago - present)</source><creator>McKay, Rachel Eshima ; Kohn, Michael ; Schwartz, Elliot ; Larson, Merlin D.</creator><creatorcontrib>McKay, Rachel Eshima ; Kohn, Michael ; Schwartz, Elliot ; Larson, Merlin D.</creatorcontrib><description>Pupillary unrest in ambient light (PUAL) describes the fluctuation of pupil diameter observed in normal, awake subjects under typical levels of indoor light. PUAL becomes low to absent in young healthy subjects during opioid intoxication. We sought to determine the age-related distribution of PUAL values in a random sample of ambulatory participants. Subjects ≥18 years of age were recruited. All were identified by age range (18–29, 30–49, 50–69, and ≥70), and surveyed for diabetes, beta-blocker use, and prior 24-hour opioid use. Relationship between mean PUAL, age group, comorbidity and opioid use were examined by Kruskal Wallis test, and PUAL and was modeled using stepwise multilevel linear regression, including diabetes, beta blocker use, prior 24-hour opioid use, autonomic dysfunction, and pupil diameter as fixed effects and subject as random effect. Among 150 subjects, 17 reported diabetes, 12 reported beta-blocker use, 14 reported prior 24-hour opioid use, and 120 reported no comorbid conditions. PUAL declined in higher age categories (by 0.0307, P &lt; 0.001), with diabetes (by 0.0481, P = 0.025), and with beta-blocker use (by 0.0616, P = 0.005). Opioid related PUAL decline was observed, but statistical significance varied by model. Among healthy subjects, no PUAL value fell within range indicating high likelihood of opioid toxicity based on previous data from healthy subjects undergoing opioid infusion. PUAL declined in higher age groups, diabetes and beta-blocker use, conditions associated with impaired autonomic function, and with opioid use but significance varied depending on the chosen model.</description><identifier>ISSN: 1566-0702</identifier><identifier>ISSN: 1872-7484</identifier><identifier>EISSN: 1872-7484</identifier><identifier>DOI: 10.1016/j.autneu.2024.103197</identifier><identifier>PMID: 38996657</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Opioid ; Pupil ; Pupillometry</subject><ispartof>Autonomic neuroscience, 2024-08, Vol.254, p.103197, Article 103197</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c241t-a000c4b0512ac31618448aa93599949fb97c6acacd449b80965970e4a4e0a34f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.autneu.2024.103197$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38996657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McKay, Rachel Eshima</creatorcontrib><creatorcontrib>Kohn, Michael</creatorcontrib><creatorcontrib>Schwartz, Elliot</creatorcontrib><creatorcontrib>Larson, Merlin D.</creatorcontrib><title>Population study of pupillary unrest in ambient light</title><title>Autonomic neuroscience</title><addtitle>Auton Neurosci</addtitle><description>Pupillary unrest in ambient light (PUAL) describes the fluctuation of pupil diameter observed in normal, awake subjects under typical levels of indoor light. PUAL becomes low to absent in young healthy subjects during opioid intoxication. We sought to determine the age-related distribution of PUAL values in a random sample of ambulatory participants. Subjects ≥18 years of age were recruited. All were identified by age range (18–29, 30–49, 50–69, and ≥70), and surveyed for diabetes, beta-blocker use, and prior 24-hour opioid use. Relationship between mean PUAL, age group, comorbidity and opioid use were examined by Kruskal Wallis test, and PUAL and was modeled using stepwise multilevel linear regression, including diabetes, beta blocker use, prior 24-hour opioid use, autonomic dysfunction, and pupil diameter as fixed effects and subject as random effect. Among 150 subjects, 17 reported diabetes, 12 reported beta-blocker use, 14 reported prior 24-hour opioid use, and 120 reported no comorbid conditions. PUAL declined in higher age categories (by 0.0307, P &lt; 0.001), with diabetes (by 0.0481, P = 0.025), and with beta-blocker use (by 0.0616, P = 0.005). Opioid related PUAL decline was observed, but statistical significance varied by model. Among healthy subjects, no PUAL value fell within range indicating high likelihood of opioid toxicity based on previous data from healthy subjects undergoing opioid infusion. PUAL declined in higher age groups, diabetes and beta-blocker use, conditions associated with impaired autonomic function, and with opioid use but significance varied depending on the chosen model.</description><subject>Opioid</subject><subject>Pupil</subject><subject>Pupillometry</subject><issn>1566-0702</issn><issn>1872-7484</issn><issn>1872-7484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EoqXwBwhlySZlnPgRb5BQxUuqBAtYW47jgKs0CX4g9e9xlcKS1YxGd-beOQhdYlhiwOxms1Qx9CYuCyhIGpVY8CM0xxUvck4qcpx6ylgOHIoZOvN-AwAVCHaKZmUlBGOUzxF9HcbYqWCHPvMhNrtsaLMxjrbrlNtlsXfGh8z2mdrW1vQh6-zHZzhHJ63qvLk41AV6f7h_Wz3l65fH59XdOtcFwSFXyVGTGigulC4xwxUhlVKipEIIItpacM2UVrohRNT7bFRwMEQRA6okbblA19Pd0Q1fMSWRW-u1Sdl6M0QvS-CiopRRSFIySbUbvHemlaOz2_SDxCD3wORGTsDkHpicgKW1q4NDrLem-Vv6JZQEt5PApD-_rXHS6wRCm8Y6o4NsBvu_ww9z130e</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>McKay, Rachel Eshima</creator><creator>Kohn, Michael</creator><creator>Schwartz, Elliot</creator><creator>Larson, Merlin D.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240801</creationdate><title>Population study of pupillary unrest in ambient light</title><author>McKay, Rachel Eshima ; Kohn, Michael ; Schwartz, Elliot ; Larson, Merlin D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c241t-a000c4b0512ac31618448aa93599949fb97c6acacd449b80965970e4a4e0a34f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Opioid</topic><topic>Pupil</topic><topic>Pupillometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McKay, Rachel Eshima</creatorcontrib><creatorcontrib>Kohn, Michael</creatorcontrib><creatorcontrib>Schwartz, Elliot</creatorcontrib><creatorcontrib>Larson, Merlin D.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Autonomic neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McKay, Rachel Eshima</au><au>Kohn, Michael</au><au>Schwartz, Elliot</au><au>Larson, Merlin D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Population study of pupillary unrest in ambient light</atitle><jtitle>Autonomic neuroscience</jtitle><addtitle>Auton Neurosci</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>254</volume><spage>103197</spage><pages>103197-</pages><artnum>103197</artnum><issn>1566-0702</issn><issn>1872-7484</issn><eissn>1872-7484</eissn><abstract>Pupillary unrest in ambient light (PUAL) describes the fluctuation of pupil diameter observed in normal, awake subjects under typical levels of indoor light. PUAL becomes low to absent in young healthy subjects during opioid intoxication. We sought to determine the age-related distribution of PUAL values in a random sample of ambulatory participants. Subjects ≥18 years of age were recruited. All were identified by age range (18–29, 30–49, 50–69, and ≥70), and surveyed for diabetes, beta-blocker use, and prior 24-hour opioid use. Relationship between mean PUAL, age group, comorbidity and opioid use were examined by Kruskal Wallis test, and PUAL and was modeled using stepwise multilevel linear regression, including diabetes, beta blocker use, prior 24-hour opioid use, autonomic dysfunction, and pupil diameter as fixed effects and subject as random effect. Among 150 subjects, 17 reported diabetes, 12 reported beta-blocker use, 14 reported prior 24-hour opioid use, and 120 reported no comorbid conditions. PUAL declined in higher age categories (by 0.0307, P &lt; 0.001), with diabetes (by 0.0481, P = 0.025), and with beta-blocker use (by 0.0616, P = 0.005). Opioid related PUAL decline was observed, but statistical significance varied by model. Among healthy subjects, no PUAL value fell within range indicating high likelihood of opioid toxicity based on previous data from healthy subjects undergoing opioid infusion. PUAL declined in higher age groups, diabetes and beta-blocker use, conditions associated with impaired autonomic function, and with opioid use but significance varied depending on the chosen model.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38996657</pmid><doi>10.1016/j.autneu.2024.103197</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1566-0702
ispartof Autonomic neuroscience, 2024-08, Vol.254, p.103197, Article 103197
issn 1566-0702
1872-7484
1872-7484
language eng
recordid cdi_proquest_miscellaneous_3079855650
source ScienceDirect Journals (5 years ago - present)
subjects Opioid
Pupil
Pupillometry
title Population study of pupillary unrest in ambient light
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T22%3A29%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Population%20study%20of%20pupillary%20unrest%20in%20ambient%20light&rft.jtitle=Autonomic%20neuroscience&rft.au=McKay,%20Rachel%20Eshima&rft.date=2024-08-01&rft.volume=254&rft.spage=103197&rft.pages=103197-&rft.artnum=103197&rft.issn=1566-0702&rft.eissn=1872-7484&rft_id=info:doi/10.1016/j.autneu.2024.103197&rft_dat=%3Cproquest_cross%3E3079855650%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3079855650&rft_id=info:pmid/38996657&rft_els_id=S1566070224000511&rfr_iscdi=true