27-Hydroxycholesterol acts on estrogen receptor α expressed by POMC neurons in the arcuate nucleus to modulate feeding behavior

Oxysterols are metabolites of cholesterol that regulate cholesterol homeostasis. Among these, the most abundant oxysterol is 27-hydroxycholesterol (27HC), which can cross the blood-brain barrier. Because 27HC functions as an endogenous selective estrogen receptor modulator, we hypothesize that 27HC...

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Veröffentlicht in:	Science advances 2024-07, Vol.10 (28), p.eadi4746
Hauptverfasser:	Ye, Hui, Yang, Xiaohua, Feng, Bing, Luo, Pei, Torres Irizarry, Valeria C, Carrillo-Sáenz, Leslie, Yu, Meng, Yang, Yongjie, Eappen, Benjamin P, Munoz, Marcos David, Patel, Nirali, Schaul, Sarah, Ibrahimi, Lucas, Lai, Penghua, Qi, Xinyue, Zhou, Yuliang, Kota, Maya, Dixit, Devin, Mun, Madeline, Liew, Chong Wee, Jiang, Yuwei, Wang, Chunmei, He, Yanlin, Xu, Pingwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arcuate Nucleus of Hypothalamus - drug effects Arcuate Nucleus of Hypothalamus - metabolism Estrogen Receptor alpha - metabolism Feeding Behavior Female Hydroxycholesterols - metabolism Hydroxycholesterols - pharmacology Mice Neurons - drug effects Neurons - metabolism Pro-Opiomelanocortin - metabolism
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