High-Throughput Covalent Modifier Screening with Acoustic Ejection Mass Spectrometry

Interests in covalent drugs have grown in modern drug discovery as they could tackle challenging targets traditionally considered “undruggable”. The identification of covalent binders to target proteins typically involves directly measuring protein covalent modifications using high-resolution mass s...

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Veröffentlicht in:	Journal of the American Chemical Society 2024-07, Vol.146 (29), p.19792-19799
Hauptverfasser:	Wen, Xiujuan, Liu, Chang, Tovar, Kiersten, Curran, Patrick, Richards, Matthew, Agrawal, Sony, Johnstone, Richard, Loy, Ryan E., Methot, Joey L., Mansueto, My Sam, Koglin, Markus, Wildey, Mary Jo, Burton, Lyle, Covey, Thomas R., Bateman, Kevin P., Kavana, Michael, McLaren, David G.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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