p53R172H and p53R245W Hotspot Mutations Drive Distinct Transcriptomes in Mouse Mammary Tumors Through a Convergent Transcriptional Mediator

Aggressive breast cancers harbor TP53 missense mutations. Tumor cells with TP53 missense mutations exhibit enhanced growth and survival through transcriptional rewiring. To delineate how TP53 mutations in breast cancer contribute to tumorigenesis and progression in vivo, we created a somatic mouse m...

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Veröffentlicht in:	Cancer research communications 2024-08, Vol.4 (8), p.1991-2007
Hauptverfasser:	McDaniel, Joy M, Morrissey, Rhiannon L, Dibra, Denada, Patel, Lalit R, Xiong, Shunbin, Zhang, Yun, Chau, Gilda P, Su, Xiaoping, Qi, Yuan, El-Naggar, Adel K, Lozano, Guillermina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Line, Tumor Female Gene Expression Regulation, Neoplastic Humans Mammary Neoplasms, Animal - genetics Mammary Neoplasms, Animal - metabolism Mammary Neoplasms, Animal - pathology Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Mice Mutation Mutation, Missense Transcriptome Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - pathology Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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