DLK1 regulates periodontal inflammation by inhibiting NF-κB p65 and JNK signaling pathways

The roles and molecular mechanisms of Delta-like 1 (DLK1) in periodontitis remain largely unknown. Here, we investigated the expression of DLK1 and NF-κB p65 in Porphyromonas gingivalis (Pg.)-induced periodontitis in vivo. Periodontal inflammation and alveolar bone resorption were analyzed using wes...

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Veröffentlicht in:	Odontology 2025-01, Vol.113 (1), p.349-357
Hauptverfasser:	Hong, Yanqing, Xu, Linlin, Yu, Xijiao, He, Yanyan, Du, Yanmei
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar bone Alveolar Bone Loss - metabolism Animals Blotting, Western Bone resorption Calcium-Binding Proteins - metabolism Cell Differentiation Computed tomography Cyclooxygenase-2 DELTA protein Dentistry Disease Models, Animal Fluorescent Antibody Technique Gum disease Immunofluorescence Immunohistochemistry Inflammation Lipopolysaccharides Lipopolysaccharides - pharmacology Macrophages MAP kinase MAP Kinase Signaling System Medicine Mice Molecular modelling NF-κB protein Nitric-oxide synthase Oral and Maxillofacial Surgery Original Article Osteoclastogenesis Osteoclasts Osteoclasts - metabolism Periodontitis Periodontitis - metabolism Porphyromonas gingivalis Preadipocyte factor 1 RAW 264.7 Cells Root resorption Signal Transduction Transcription Factor RelA - metabolism Transfection Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Western blotting X-Ray Microtomography
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