Quantification of oxidative stress markers in the blood sera following subacute administration of different oximes in rats
Oxidative stress status, as a disruption of redox homeostasis, in the blood sera of Wistar rats caused by repeated application of selected acetylcholinesterase reactivators - asoxime, obidoxime, K027, K048, K074, and K075 were evaluated. Throughout this study, each oxime in a dose of 0.1 of LD50/kg...
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| Veröffentlicht in: | Chemico-biological interactions 2024-08, Vol.399, p.111138, Article 111138 |
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| creator | Jaćević, Vesna Grujić-Milanović, Jelica Milovanović, Zoran Nežić, Lana Amidžić, Ljiljana Vojinović, Nataša Marković, Bojan Dobričić, Vladimir Milosavljević, Petar Nepovimova, Eugenie Kuča, Kamil |
| description | Oxidative stress status, as a disruption of redox homeostasis, in the blood sera of Wistar rats caused by repeated application of selected acetylcholinesterase reactivators - asoxime, obidoxime, K027, K048, K074, and K075 were evaluated. Throughout this study, each oxime in a dose of 0.1 of LD50/kg im was given 2x/week for 4 weeks. Then, seven days after the last oximes' application, markers of lipid peroxidation (malondialdehyde, MDA), and protein oxidation (advanced oxidation protein products, AOPP), as well as the activity of antioxidant enzymes (catalase, CAT, superoxide dismutase, SOD, reduced glutathione, GSH, and oxidized glutathione, GSSG), were determined. Oxidative stress parameters, MDA and AOPP were significantly highest in the K048-, K074- and K075-treated groups (p |
| doi_str_mv | 10.1016/j.cbi.2024.111138 |
| format | Article |
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•Treatment by asoxime and K027 reduces markers of lipid peroxidation in rats.•Oxime K048, K074 and K075 elevated the protein oxidation levels in treated rats.•The activity of catalase was markedly elevated in the obidoxime-treated rats.•The superoxide dismutase levels increased in K027-, K048- and K074-treated rats.•Each oxime induced elevation of glutathione peroxidase in treated rats.</description><identifier>ISSN: 0009-2797</identifier><identifier>ISSN: 1872-7786</identifier><identifier>EISSN: 1872-7786</identifier><identifier>DOI: 10.1016/j.cbi.2024.111138</identifier><identifier>PMID: 38992768</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Blood sera ; Oxidative stress ; Oximes ; Rats ; Subacute toxicity</subject><ispartof>Chemico-biological interactions, 2024-08, Vol.399, p.111138, Article 111138</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024. Published by Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c235t-5b83e23635b9f61300ff1552c1a3c95419359219aa27a0385f081c5be76cd1c33</cites><orcidid>0000-0001-5137-2638</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cbi.2024.111138$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38992768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jaćević, Vesna</creatorcontrib><creatorcontrib>Grujić-Milanović, Jelica</creatorcontrib><creatorcontrib>Milovanović, Zoran</creatorcontrib><creatorcontrib>Nežić, Lana</creatorcontrib><creatorcontrib>Amidžić, Ljiljana</creatorcontrib><creatorcontrib>Vojinović, Nataša</creatorcontrib><creatorcontrib>Marković, Bojan</creatorcontrib><creatorcontrib>Dobričić, Vladimir</creatorcontrib><creatorcontrib>Milosavljević, Petar</creatorcontrib><creatorcontrib>Nepovimova, Eugenie</creatorcontrib><creatorcontrib>Kuča, Kamil</creatorcontrib><title>Quantification of oxidative stress markers in the blood sera following subacute administration of different oximes in rats</title><title>Chemico-biological interactions</title><addtitle>Chem Biol Interact</addtitle><description>Oxidative stress status, as a disruption of redox homeostasis, in the blood sera of Wistar rats caused by repeated application of selected acetylcholinesterase reactivators - asoxime, obidoxime, K027, K048, K074, and K075 were evaluated. Throughout this study, each oxime in a dose of 0.1 of LD50/kg im was given 2x/week for 4 weeks. Then, seven days after the last oximes' application, markers of lipid peroxidation (malondialdehyde, MDA), and protein oxidation (advanced oxidation protein products, AOPP), as well as the activity of antioxidant enzymes (catalase, CAT, superoxide dismutase, SOD, reduced glutathione, GSH, and oxidized glutathione, GSSG), were determined. Oxidative stress parameters, MDA and AOPP were significantly highest in the K048-, K074- and K075-treated groups (p < 0.001). The activity of CAT was significantly elevated in the obidoxime-treated group (p < 0.05), while treatment with K027, K048, and K074 induced high elevation in SOD levels (p < 0.01, p < 0.001). Interestingly, the activity of GSH in each oxime-treated group was significantly elevated. Unlike, treatment with obidoxime caused elevation in GSSG levels (p < 0.01). As a continuation of our previously published data, these results assure that applied oximes following subacute treatment ameliorated the oxidative status and further adverse systemic toxic effects in rats.
•Treatment by asoxime and K027 reduces markers of lipid peroxidation in rats.•Oxime K048, K074 and K075 elevated the protein oxidation levels in treated rats.•The activity of catalase was markedly elevated in the obidoxime-treated rats.•The superoxide dismutase levels increased in K027-, K048- and K074-treated rats.•Each oxime induced elevation of glutathione peroxidase in treated rats.</description><subject>Blood sera</subject><subject>Oxidative stress</subject><subject>Oximes</subject><subject>Rats</subject><subject>Subacute toxicity</subject><issn>0009-2797</issn><issn>1872-7786</issn><issn>1872-7786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kM1OGzEURi0EKmnoA7CpvGQzwT_xeKyuqqjQSpEQEqwtj-e6dZgZp7YHKE-PQ2iWeGNd3e870j0InVOyoITWl5uFbf2CEbZc0PJ4c4RmtJGskrKpj9GMEKIqJpU8RZ9T2pSxRMkndMobpZismxl6uZ3MmL3z1mQfRhwcDs--K8Mj4JQjpIQHEx8gJuxHnP8AbvsQOpwgGuxC34cnP_7GaWqNnTJg0w1-9KV54HXeOYgw5h15gDdO2aYzdOJMn-DL-z9H91c_7lY_q_XN9a_V93VlGRe5Em3DgfGai1a5mnJCnKNCMEsNt0osqeJCMaqMYdIQ3ghHGmpFC7K2HbWcz9HFnruN4e8EKevBJwt9b0YIU9KcSEVl4dYlSvdRG0NKEZzeRl_O_6cp0TvleqOLcr1TrvfKS-frO35qB-gOjf-OS-DbPgDlyEcPUSfrYbTQ-Qg26y74D_Cv5M2SyQ</recordid><startdate>20240825</startdate><enddate>20240825</enddate><creator>Jaćević, Vesna</creator><creator>Grujić-Milanović, Jelica</creator><creator>Milovanović, Zoran</creator><creator>Nežić, Lana</creator><creator>Amidžić, Ljiljana</creator><creator>Vojinović, Nataša</creator><creator>Marković, Bojan</creator><creator>Dobričić, Vladimir</creator><creator>Milosavljević, Petar</creator><creator>Nepovimova, Eugenie</creator><creator>Kuča, Kamil</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5137-2638</orcidid></search><sort><creationdate>20240825</creationdate><title>Quantification of oxidative stress markers in the blood sera following subacute administration of different oximes in rats</title><author>Jaćević, Vesna ; Grujić-Milanović, Jelica ; Milovanović, Zoran ; Nežić, Lana ; Amidžić, Ljiljana ; Vojinović, Nataša ; Marković, Bojan ; Dobričić, Vladimir ; Milosavljević, Petar ; Nepovimova, Eugenie ; Kuča, Kamil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c235t-5b83e23635b9f61300ff1552c1a3c95419359219aa27a0385f081c5be76cd1c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Blood sera</topic><topic>Oxidative stress</topic><topic>Oximes</topic><topic>Rats</topic><topic>Subacute toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jaćević, Vesna</creatorcontrib><creatorcontrib>Grujić-Milanović, Jelica</creatorcontrib><creatorcontrib>Milovanović, Zoran</creatorcontrib><creatorcontrib>Nežić, Lana</creatorcontrib><creatorcontrib>Amidžić, Ljiljana</creatorcontrib><creatorcontrib>Vojinović, Nataša</creatorcontrib><creatorcontrib>Marković, Bojan</creatorcontrib><creatorcontrib>Dobričić, Vladimir</creatorcontrib><creatorcontrib>Milosavljević, Petar</creatorcontrib><creatorcontrib>Nepovimova, Eugenie</creatorcontrib><creatorcontrib>Kuča, Kamil</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemico-biological interactions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jaćević, Vesna</au><au>Grujić-Milanović, Jelica</au><au>Milovanović, Zoran</au><au>Nežić, Lana</au><au>Amidžić, Ljiljana</au><au>Vojinović, Nataša</au><au>Marković, Bojan</au><au>Dobričić, Vladimir</au><au>Milosavljević, Petar</au><au>Nepovimova, Eugenie</au><au>Kuča, Kamil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantification of oxidative stress markers in the blood sera following subacute administration of different oximes in rats</atitle><jtitle>Chemico-biological interactions</jtitle><addtitle>Chem Biol Interact</addtitle><date>2024-08-25</date><risdate>2024</risdate><volume>399</volume><spage>111138</spage><pages>111138-</pages><artnum>111138</artnum><issn>0009-2797</issn><issn>1872-7786</issn><eissn>1872-7786</eissn><abstract>Oxidative stress status, as a disruption of redox homeostasis, in the blood sera of Wistar rats caused by repeated application of selected acetylcholinesterase reactivators - asoxime, obidoxime, K027, K048, K074, and K075 were evaluated. Throughout this study, each oxime in a dose of 0.1 of LD50/kg im was given 2x/week for 4 weeks. Then, seven days after the last oximes' application, markers of lipid peroxidation (malondialdehyde, MDA), and protein oxidation (advanced oxidation protein products, AOPP), as well as the activity of antioxidant enzymes (catalase, CAT, superoxide dismutase, SOD, reduced glutathione, GSH, and oxidized glutathione, GSSG), were determined. Oxidative stress parameters, MDA and AOPP were significantly highest in the K048-, K074- and K075-treated groups (p < 0.001). The activity of CAT was significantly elevated in the obidoxime-treated group (p < 0.05), while treatment with K027, K048, and K074 induced high elevation in SOD levels (p < 0.01, p < 0.001). Interestingly, the activity of GSH in each oxime-treated group was significantly elevated. Unlike, treatment with obidoxime caused elevation in GSSG levels (p < 0.01). As a continuation of our previously published data, these results assure that applied oximes following subacute treatment ameliorated the oxidative status and further adverse systemic toxic effects in rats.
•Treatment by asoxime and K027 reduces markers of lipid peroxidation in rats.•Oxime K048, K074 and K075 elevated the protein oxidation levels in treated rats.•The activity of catalase was markedly elevated in the obidoxime-treated rats.•The superoxide dismutase levels increased in K027-, K048- and K074-treated rats.•Each oxime induced elevation of glutathione peroxidase in treated rats.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>38992768</pmid><doi>10.1016/j.cbi.2024.111138</doi><orcidid>https://orcid.org/0000-0001-5137-2638</orcidid></addata></record> |
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| subjects | Blood sera Oxidative stress Oximes Rats Subacute toxicity |
| title | Quantification of oxidative stress markers in the blood sera following subacute administration of different oximes in rats |
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