Clinical features and prognosis of conjunctival melanoma in Japanese patients
Purpose To evaluate the clinical features and prognosis of conjunctival melanoma in Japanese patients. Study design Retrospective observational case series. Methods Twenty patients (8 men and 12 women) diagnosed with conjunctival melanoma at a singlehospital between 2003 and 2017 were analyzed. Data...
Gespeichert in:
| Veröffentlicht in: | Japanese journal of ophthalmology 2024-09, Vol.68 (5), p.463-471 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 471 |
|---|---|
| container_issue | 5 |
| container_start_page | 463 |
| container_title | Japanese journal of ophthalmology |
| container_volume | 68 |
| creator | Tanabe, Mika Funatsu, Naohiko Akiyama, Masato Takaki, Ken-Ichi Fujii, Yuya Seki, Eiko Yamana, Kanako Yoshikawa, Hiroshi Sonoda, Koh-Hei |
| description | Purpose
To evaluate the clinical features and prognosis of conjunctival melanoma in Japanese patients.
Study design
Retrospective observational case series.
Methods
Twenty patients (8 men and 12 women) diagnosed with conjunctival melanoma at a singlehospital between 2003 and 2017 were analyzed. Data on clinical presentation, sex, age, the affected eye, tumor location, tumor origin, tumor stage according to the American Joint Committee on Cancer staging system (eighth edition), treatment, outcomes, local recurrence, metastasis, and survival were extracted from the patients’ medical records and reviewed.
Results
The mean age at diagnosis was 64.2 ± 14.8 years. Tumor locations at the first examination included the bulbar conjunctiva (
n
= 19), plica (
n
= 13), and fornix (
n
= 12). The tumor stage was T1 in 5 cases (25%), T2 in 12 cases (60%), T3 in 3 cases (15%), and T4 in none. The mean follow-up duration was 91.7 ± 46.0 months. The local recurrence rates at 1, 5, and 10 years were 5.0%, 18.8%, and 31.5%, respectively, whilst the metastasis rates were 5.0%, 25.6%, and 32.4%, respectively. Four of the 6 patients who experienced metastasis died; duration from metastasis to death was 17.5 months (range, 7–25). The 5-year survival rate for conjunctival melanoma was 78.8%. Tumor thickness was significantly associated with survival duration on univariate Cox regression analyses.
Conclusion
The mortality rate for conjunctival melanoma in the Japanese population was lower and higher than that reported in the Chinese and United States populations, respectively. Tumor thickness was a prognostic factor for survival in patients with conjunctival melanoma. |
| doi_str_mv | 10.1007/s10384-024-01085-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3078717657</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3078717657</sourcerecordid><originalsourceid>FETCH-LOGICAL-c349t-8c44b98151fa5b97fb16c9b7686b7a64c237175668aaf61e51ef075bf06dc4b83</originalsourceid><addsrcrecordid>eNp9kE1LwzAAhoMobk7_gAcpePFSzXfSoww_UbzoOSRZMjLadDat4H690U4FDx5CDnneNy8PAMcIniMIxUVCkEhaQpwPgpKVmx0wRRyREmPKd8EUQoxKhhibgIOUVhBCigneBxMiqypnxRQ8zusQg9V14Z3uh86lQsdFse7aZWxTSEXrC9vG1RBtH94y1rhax7bRRYjFvV7r6JIr1roPLvbpEOx5XSd3tL1n4OX66nl-Wz483dzNLx9KS2jVl9JSaiqJGPKamUp4g7itjOCSG6E5tZgIJBjnUmvPkWPIeSiY8ZAvLDWSzMDZ2Jt3vg4u9aoJybo6T3PtkBSBQuYGzkRGT_-gq3boYl6nSJYmcCUkyxQeKdu1KXXOq3UXGt29KwTVp2w1ylZZtvqSrTY5dLKtHkzjFj-Rb7sZICOQ8lNcuu73739qPwAIZooz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3108729785</pqid></control><display><type>article</type><title>Clinical features and prognosis of conjunctival melanoma in Japanese patients</title><source>Springer Nature - Complete Springer Journals</source><creator>Tanabe, Mika ; Funatsu, Naohiko ; Akiyama, Masato ; Takaki, Ken-Ichi ; Fujii, Yuya ; Seki, Eiko ; Yamana, Kanako ; Yoshikawa, Hiroshi ; Sonoda, Koh-Hei</creator><creatorcontrib>Tanabe, Mika ; Funatsu, Naohiko ; Akiyama, Masato ; Takaki, Ken-Ichi ; Fujii, Yuya ; Seki, Eiko ; Yamana, Kanako ; Yoshikawa, Hiroshi ; Sonoda, Koh-Hei</creatorcontrib><description>Purpose
To evaluate the clinical features and prognosis of conjunctival melanoma in Japanese patients.
Study design
Retrospective observational case series.
Methods
Twenty patients (8 men and 12 women) diagnosed with conjunctival melanoma at a singlehospital between 2003 and 2017 were analyzed. Data on clinical presentation, sex, age, the affected eye, tumor location, tumor origin, tumor stage according to the American Joint Committee on Cancer staging system (eighth edition), treatment, outcomes, local recurrence, metastasis, and survival were extracted from the patients’ medical records and reviewed.
Results
The mean age at diagnosis was 64.2 ± 14.8 years. Tumor locations at the first examination included the bulbar conjunctiva (
n
= 19), plica (
n
= 13), and fornix (
n
= 12). The tumor stage was T1 in 5 cases (25%), T2 in 12 cases (60%), T3 in 3 cases (15%), and T4 in none. The mean follow-up duration was 91.7 ± 46.0 months. The local recurrence rates at 1, 5, and 10 years were 5.0%, 18.8%, and 31.5%, respectively, whilst the metastasis rates were 5.0%, 25.6%, and 32.4%, respectively. Four of the 6 patients who experienced metastasis died; duration from metastasis to death was 17.5 months (range, 7–25). The 5-year survival rate for conjunctival melanoma was 78.8%. Tumor thickness was significantly associated with survival duration on univariate Cox regression analyses.
Conclusion
The mortality rate for conjunctival melanoma in the Japanese population was lower and higher than that reported in the Chinese and United States populations, respectively. Tumor thickness was a prognostic factor for survival in patients with conjunctival melanoma.</description><identifier>ISSN: 0021-5155</identifier><identifier>ISSN: 1613-2246</identifier><identifier>EISSN: 1613-2246</identifier><identifier>DOI: 10.1007/s10384-024-01085-z</identifier><identifier>PMID: 38990387</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Clinical Investigation ; Conjunctiva ; Eye cancer ; Fornix ; Medical prognosis ; Medical records ; Medicine ; Medicine & Public Health ; Melanoma ; Metastases ; Metastasis ; Ophthalmology ; Patients ; Prognosis ; Regression analysis ; Survival ; Thickness ; Tumors</subject><ispartof>Japanese journal of ophthalmology, 2024-09, Vol.68 (5), p.463-471</ispartof><rights>Japanese Ophthalmological Society 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. Japanese Ophthalmological Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c349t-8c44b98151fa5b97fb16c9b7686b7a64c237175668aaf61e51ef075bf06dc4b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10384-024-01085-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10384-024-01085-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38990387$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanabe, Mika</creatorcontrib><creatorcontrib>Funatsu, Naohiko</creatorcontrib><creatorcontrib>Akiyama, Masato</creatorcontrib><creatorcontrib>Takaki, Ken-Ichi</creatorcontrib><creatorcontrib>Fujii, Yuya</creatorcontrib><creatorcontrib>Seki, Eiko</creatorcontrib><creatorcontrib>Yamana, Kanako</creatorcontrib><creatorcontrib>Yoshikawa, Hiroshi</creatorcontrib><creatorcontrib>Sonoda, Koh-Hei</creatorcontrib><title>Clinical features and prognosis of conjunctival melanoma in Japanese patients</title><title>Japanese journal of ophthalmology</title><addtitle>Jpn J Ophthalmol</addtitle><addtitle>Jpn J Ophthalmol</addtitle><description>Purpose
To evaluate the clinical features and prognosis of conjunctival melanoma in Japanese patients.
Study design
Retrospective observational case series.
Methods
Twenty patients (8 men and 12 women) diagnosed with conjunctival melanoma at a singlehospital between 2003 and 2017 were analyzed. Data on clinical presentation, sex, age, the affected eye, tumor location, tumor origin, tumor stage according to the American Joint Committee on Cancer staging system (eighth edition), treatment, outcomes, local recurrence, metastasis, and survival were extracted from the patients’ medical records and reviewed.
Results
The mean age at diagnosis was 64.2 ± 14.8 years. Tumor locations at the first examination included the bulbar conjunctiva (
n
= 19), plica (
n
= 13), and fornix (
n
= 12). The tumor stage was T1 in 5 cases (25%), T2 in 12 cases (60%), T3 in 3 cases (15%), and T4 in none. The mean follow-up duration was 91.7 ± 46.0 months. The local recurrence rates at 1, 5, and 10 years were 5.0%, 18.8%, and 31.5%, respectively, whilst the metastasis rates were 5.0%, 25.6%, and 32.4%, respectively. Four of the 6 patients who experienced metastasis died; duration from metastasis to death was 17.5 months (range, 7–25). The 5-year survival rate for conjunctival melanoma was 78.8%. Tumor thickness was significantly associated with survival duration on univariate Cox regression analyses.
Conclusion
The mortality rate for conjunctival melanoma in the Japanese population was lower and higher than that reported in the Chinese and United States populations, respectively. Tumor thickness was a prognostic factor for survival in patients with conjunctival melanoma.</description><subject>Clinical Investigation</subject><subject>Conjunctiva</subject><subject>Eye cancer</subject><subject>Fornix</subject><subject>Medical prognosis</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Melanoma</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Ophthalmology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Regression analysis</subject><subject>Survival</subject><subject>Thickness</subject><subject>Tumors</subject><issn>0021-5155</issn><issn>1613-2246</issn><issn>1613-2246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LwzAAhoMobk7_gAcpePFSzXfSoww_UbzoOSRZMjLadDat4H690U4FDx5CDnneNy8PAMcIniMIxUVCkEhaQpwPgpKVmx0wRRyREmPKd8EUQoxKhhibgIOUVhBCigneBxMiqypnxRQ8zusQg9V14Z3uh86lQsdFse7aZWxTSEXrC9vG1RBtH94y1rhax7bRRYjFvV7r6JIr1roPLvbpEOx5XSd3tL1n4OX66nl-Wz483dzNLx9KS2jVl9JSaiqJGPKamUp4g7itjOCSG6E5tZgIJBjnUmvPkWPIeSiY8ZAvLDWSzMDZ2Jt3vg4u9aoJybo6T3PtkBSBQuYGzkRGT_-gq3boYl6nSJYmcCUkyxQeKdu1KXXOq3UXGt29KwTVp2w1ylZZtvqSrTY5dLKtHkzjFj-Rb7sZICOQ8lNcuu73739qPwAIZooz</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Tanabe, Mika</creator><creator>Funatsu, Naohiko</creator><creator>Akiyama, Masato</creator><creator>Takaki, Ken-Ichi</creator><creator>Fujii, Yuya</creator><creator>Seki, Eiko</creator><creator>Yamana, Kanako</creator><creator>Yoshikawa, Hiroshi</creator><creator>Sonoda, Koh-Hei</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20240901</creationdate><title>Clinical features and prognosis of conjunctival melanoma in Japanese patients</title><author>Tanabe, Mika ; Funatsu, Naohiko ; Akiyama, Masato ; Takaki, Ken-Ichi ; Fujii, Yuya ; Seki, Eiko ; Yamana, Kanako ; Yoshikawa, Hiroshi ; Sonoda, Koh-Hei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-8c44b98151fa5b97fb16c9b7686b7a64c237175668aaf61e51ef075bf06dc4b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Clinical Investigation</topic><topic>Conjunctiva</topic><topic>Eye cancer</topic><topic>Fornix</topic><topic>Medical prognosis</topic><topic>Medical records</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Melanoma</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Ophthalmology</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Regression analysis</topic><topic>Survival</topic><topic>Thickness</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanabe, Mika</creatorcontrib><creatorcontrib>Funatsu, Naohiko</creatorcontrib><creatorcontrib>Akiyama, Masato</creatorcontrib><creatorcontrib>Takaki, Ken-Ichi</creatorcontrib><creatorcontrib>Fujii, Yuya</creatorcontrib><creatorcontrib>Seki, Eiko</creatorcontrib><creatorcontrib>Yamana, Kanako</creatorcontrib><creatorcontrib>Yoshikawa, Hiroshi</creatorcontrib><creatorcontrib>Sonoda, Koh-Hei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanabe, Mika</au><au>Funatsu, Naohiko</au><au>Akiyama, Masato</au><au>Takaki, Ken-Ichi</au><au>Fujii, Yuya</au><au>Seki, Eiko</au><au>Yamana, Kanako</au><au>Yoshikawa, Hiroshi</au><au>Sonoda, Koh-Hei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical features and prognosis of conjunctival melanoma in Japanese patients</atitle><jtitle>Japanese journal of ophthalmology</jtitle><stitle>Jpn J Ophthalmol</stitle><addtitle>Jpn J Ophthalmol</addtitle><date>2024-09-01</date><risdate>2024</risdate><volume>68</volume><issue>5</issue><spage>463</spage><epage>471</epage><pages>463-471</pages><issn>0021-5155</issn><issn>1613-2246</issn><eissn>1613-2246</eissn><abstract>Purpose
To evaluate the clinical features and prognosis of conjunctival melanoma in Japanese patients.
Study design
Retrospective observational case series.
Methods
Twenty patients (8 men and 12 women) diagnosed with conjunctival melanoma at a singlehospital between 2003 and 2017 were analyzed. Data on clinical presentation, sex, age, the affected eye, tumor location, tumor origin, tumor stage according to the American Joint Committee on Cancer staging system (eighth edition), treatment, outcomes, local recurrence, metastasis, and survival were extracted from the patients’ medical records and reviewed.
Results
The mean age at diagnosis was 64.2 ± 14.8 years. Tumor locations at the first examination included the bulbar conjunctiva (
n
= 19), plica (
n
= 13), and fornix (
n
= 12). The tumor stage was T1 in 5 cases (25%), T2 in 12 cases (60%), T3 in 3 cases (15%), and T4 in none. The mean follow-up duration was 91.7 ± 46.0 months. The local recurrence rates at 1, 5, and 10 years were 5.0%, 18.8%, and 31.5%, respectively, whilst the metastasis rates were 5.0%, 25.6%, and 32.4%, respectively. Four of the 6 patients who experienced metastasis died; duration from metastasis to death was 17.5 months (range, 7–25). The 5-year survival rate for conjunctival melanoma was 78.8%. Tumor thickness was significantly associated with survival duration on univariate Cox regression analyses.
Conclusion
The mortality rate for conjunctival melanoma in the Japanese population was lower and higher than that reported in the Chinese and United States populations, respectively. Tumor thickness was a prognostic factor for survival in patients with conjunctival melanoma.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>38990387</pmid><doi>10.1007/s10384-024-01085-z</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-5155 |
| ispartof | Japanese journal of ophthalmology, 2024-09, Vol.68 (5), p.463-471 |
| issn | 0021-5155 1613-2246 1613-2246 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3078717657 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Clinical Investigation Conjunctiva Eye cancer Fornix Medical prognosis Medical records Medicine Medicine & Public Health Melanoma Metastases Metastasis Ophthalmology Patients Prognosis Regression analysis Survival Thickness Tumors |
| title | Clinical features and prognosis of conjunctival melanoma in Japanese patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T14%3A38%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20features%20and%20prognosis%20of%20conjunctival%20melanoma%20in%20Japanese%20patients&rft.jtitle=Japanese%20journal%20of%20ophthalmology&rft.au=Tanabe,%20Mika&rft.date=2024-09-01&rft.volume=68&rft.issue=5&rft.spage=463&rft.epage=471&rft.pages=463-471&rft.issn=0021-5155&rft.eissn=1613-2246&rft_id=info:doi/10.1007/s10384-024-01085-z&rft_dat=%3Cproquest_cross%3E3078717657%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3108729785&rft_id=info:pmid/38990387&rfr_iscdi=true |