Efficacy and safety of LAU-7b in a Phase 2 trial in adults with cystic fibrosis

•Pulmonary inflammation persists despite highly effective CFTR modulator therapy.•Fenretinide, a retinoic acid derivative, acts on cell membrane lipids to control inflammation and protein trafficking.•A 24-week course of oral fenretinide was investigated for the first time in adults with Cystic Fibr...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of cystic fibrosis 2024-07
Hauptverfasser:	Konstan, Michael W., Polineni, Deepika, Chmiel, James F., Bilodeau, Lara, Middleton, Peter G., Matouk, Elias, Houle, Jean-Marie, Pislariu, Radu, Colin, Patrick, Kianicka, Irenej, Potvin, Diane, Radzioch, Danuta, Kotsimbos, Tom, Zuckerman, Jonathan B., Nasr, Samya Z., Liou, Theodore G., Lands, Larry C.
Format:	Artikel
Sprache:	eng
Schlagworte:	CFTR modulators Cystic fibrosis Inflammation LAU-7b Lung function loss reduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!