Natural carriage of Streptococcus pneumoniae is associated with increased experimental pneumococcal carriage but reduced conjugate vaccine efficacy in a human challenge model

In Malawi, the national pneumococcal conjugate vaccine (PCV13) demonstrated less herd immunity than the USA, likely due to higher natural pneumococcal carriage rates. We assessed PCV13 efficacy against experimental pneumococcal carriage in healthy Malawian adults. We explored how natural carriage (p...

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Veröffentlicht in:	The Journal of infectious diseases 2024-07
Hauptverfasser:	Galafa, Bridgette, Chikaonda, Tarsizio, Kudowa, Evaristar, Sichone, Simon, Sibale, Lusako, Thole, Faith, Mkandawire, Christopher, Dula, Dingase, Nsomba, Edna, Tembo, Godwin, Chaponda, Mphatso, Chirwa, Anthony E, Nkhoma, Vitumbiko, Ngoliwa, Clara, Kamng'ona, Raphael, Toto, Neema, Makhaza, Lumbani, Muyaya, Alfred, Howard, Ashleigh, Nyazika, Tinashe K, Ndaferankhande, John, Chimgoneko, Lorensio, Banda, Ndaziona P K, Chiwala, Gift, Rylance, Jamie, Ferreira, Daniela, Jambo, Kondwani C, Morton, Ben, Henrion, Marc Y R, Gordon, Stephen B
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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