Design, in silico Evaluation, and Determination of Antitumor Activity of Potential Inhibitors Against Protein Kinases: Application to BCR-ABL Tyrosine Kinase

Despite significant progress made over the past two decades in the treatment of chronic myeloid leukemia (CML), there is still an unmet need for effective and safe agents to treat patients with resistance and intolerance to the drugs used in clinic. In this work, we designed 2-arylaminopyrimidine am...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemistry (Moscow) 2024-06, Vol.89 (6), p.1094-1108
Hauptverfasser:	Koroleva, Elena V., Ermolinskaya, Anastasiya L., Ignatovich, Zhanna V., Kornoushenko, Yury V., Panibrat, Alesia V., Potkin, Vladimir I., Andrianov, Alexander M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute promyeloid leukemia Amides Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antineoplastic drugs Antitumor activity Antitumor agents BCR-ABL protein Binding sites Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Cancer therapies Carboxylic acids Catalytic activity Cell Proliferation - drug effects Cervical cancer Chronic myeloid leukemia Computational chemistry Computer Simulation Drug Design Drug development Drug resistance Drug Screening Assays, Antitumor Drug therapy Drugs Effectiveness Enzyme inhibitors Fusion protein Fusion Proteins, bcr-abl - antagonists & inhibitors Fusion Proteins, bcr-abl - metabolism HeLa Cells HL-60 Cells Humans K562 Cells Kinases Lead compounds Leukemia Life Sciences Microbiology Molecular Docking Simulation Myeloid leukemia Promyeloid leukemia Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Pyrimidines - chemistry Pyrimidines - pharmacology Tyrosine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!