Sirtuin insights: bridging the gap between cellular processes and therapeutic applications
The greatest challenges that organisms face today are effective responses or detection of life-threatening environmental changes due to an obvious semblance of stress and metabolic fluctuations. These are associated with different pathological conditions among which cancer is most important. Sirtuin...
Gespeichert in:
| Veröffentlicht in: | Naunyn-Schmiedeberg's archives of pharmacology 2024-12, Vol.397 (12), p.9315-9344 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 9344 |
|---|---|
| container_issue | 12 |
| container_start_page | 9315 |
| container_title | Naunyn-Schmiedeberg's archives of pharmacology |
| container_volume | 397 |
| creator | Kamal, Shagufta Babar, Sharon Ali, Waqas Rehman, Kanwal Hussain, Amjad Akash, Muhammad Sajid Hamid |
| description | The greatest challenges that organisms face today are effective responses or detection of life-threatening environmental changes due to an obvious semblance of stress and metabolic fluctuations. These are associated with different pathological conditions among which cancer is most important. Sirtuins (SIRTs; NAD
+
-dependent enzymes) are versatile enzymes with diverse substrate preferences, cellular locations, crucial for cellular processes and pathological conditions. This article describes in detail the distinct roles of SIRT isoforms, unveiling their potential as either cancer promoters or suppressors and also explores how both natural and synthetic compounds influence the SIRT function, indicating promise for therapeutic applications. We also discussed the inhibitors/activators tailored to specific SIRTs, holding potential for diseases lacking effective treatments. It may uncover the lesser-studied SIRT isoforms (e.g., SIRT6, SIRT7) and their unique functions. This article also offers a comprehensive overview of SIRTs, linking them to a spectrum of diseases and highlighting their potential for targeted therapies, combination approaches, disease management, and personalized medicine. We aim to contribute to a transformative era in healthcare and innovative treatments by unraveling the intricate functions of SIRTs. |
| doi_str_mv | 10.1007/s00210-024-03263-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3076766854</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3131662741</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-51a559dfd1d3c609db326a541cc99b78447dc596ebda67c8d1a5c51805aa687c3</originalsourceid><addsrcrecordid>eNp9kLtOwzAUhi0EouXyAgzIEgtLwJfYjtkQ4iYhMQALi-XYbuoqdYKdCPH2uLSAxMDk4Xzn938-AI4wOsMIifOEEMGoQKQsECWcFnILTHFJSYElJttgmudVgYmsJmAvpQVCiGPGdsGEVlJwVPIpeH3ycRh9gD4k38yHdAHr6G3jQwOHuYON7mHthnfnAjSubcdWR9jHzriUXII62BUWde_GwRuo-771Rg--C-kA7Mx0m9zh5t0HLzfXz1d3xcPj7f3V5UNhCONDwbBmTNqZxZYajqSt8y2aldgYKWtRlaWwhknuaqu5MJXNvGG4QkxrXglD98HpOjfXehtdGtTSp1VXHVw3JkWR4ILzipUZPfmDLroxhtxOUUwx50SUOFNkTZnYpRTdTPXRL3X8UBiplXm1Nq-yefVlXsm8dLyJHuulsz8r36ozQNdAyqPQuPj79z-xn8MWjtM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3131662741</pqid></control><display><type>article</type><title>Sirtuin insights: bridging the gap between cellular processes and therapeutic applications</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Kamal, Shagufta ; Babar, Sharon ; Ali, Waqas ; Rehman, Kanwal ; Hussain, Amjad ; Akash, Muhammad Sajid Hamid</creator><creatorcontrib>Kamal, Shagufta ; Babar, Sharon ; Ali, Waqas ; Rehman, Kanwal ; Hussain, Amjad ; Akash, Muhammad Sajid Hamid</creatorcontrib><description>The greatest challenges that organisms face today are effective responses or detection of life-threatening environmental changes due to an obvious semblance of stress and metabolic fluctuations. These are associated with different pathological conditions among which cancer is most important. Sirtuins (SIRTs; NAD
+
-dependent enzymes) are versatile enzymes with diverse substrate preferences, cellular locations, crucial for cellular processes and pathological conditions. This article describes in detail the distinct roles of SIRT isoforms, unveiling their potential as either cancer promoters or suppressors and also explores how both natural and synthetic compounds influence the SIRT function, indicating promise for therapeutic applications. We also discussed the inhibitors/activators tailored to specific SIRTs, holding potential for diseases lacking effective treatments. It may uncover the lesser-studied SIRT isoforms (e.g., SIRT6, SIRT7) and their unique functions. This article also offers a comprehensive overview of SIRTs, linking them to a spectrum of diseases and highlighting their potential for targeted therapies, combination approaches, disease management, and personalized medicine. We aim to contribute to a transformative era in healthcare and innovative treatments by unraveling the intricate functions of SIRTs.</description><identifier>ISSN: 0028-1298</identifier><identifier>ISSN: 1432-1912</identifier><identifier>EISSN: 1432-1912</identifier><identifier>DOI: 10.1007/s00210-024-03263-9</identifier><identifier>PMID: 38976046</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Environmental changes ; Enzymes ; Humans ; Isoforms ; Medical treatment ; Molecular Targeted Therapy ; Neoplasms - drug therapy ; Neoplasms - metabolism ; Neurosciences ; Pharmacology/Toxicology ; Precision Medicine ; Review ; Sirtuins ; Sirtuins - metabolism ; Substrate preferences ; Therapeutic applications</subject><ispartof>Naunyn-Schmiedeberg's archives of pharmacology, 2024-12, Vol.397 (12), p.9315-9344</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-51a559dfd1d3c609db326a541cc99b78447dc596ebda67c8d1a5c51805aa687c3</cites><orcidid>0000-0002-9446-5233</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00210-024-03263-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00210-024-03263-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38976046$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamal, Shagufta</creatorcontrib><creatorcontrib>Babar, Sharon</creatorcontrib><creatorcontrib>Ali, Waqas</creatorcontrib><creatorcontrib>Rehman, Kanwal</creatorcontrib><creatorcontrib>Hussain, Amjad</creatorcontrib><creatorcontrib>Akash, Muhammad Sajid Hamid</creatorcontrib><title>Sirtuin insights: bridging the gap between cellular processes and therapeutic applications</title><title>Naunyn-Schmiedeberg's archives of pharmacology</title><addtitle>Naunyn-Schmiedeberg's Arch Pharmacol</addtitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><description>The greatest challenges that organisms face today are effective responses or detection of life-threatening environmental changes due to an obvious semblance of stress and metabolic fluctuations. These are associated with different pathological conditions among which cancer is most important. Sirtuins (SIRTs; NAD
+
-dependent enzymes) are versatile enzymes with diverse substrate preferences, cellular locations, crucial for cellular processes and pathological conditions. This article describes in detail the distinct roles of SIRT isoforms, unveiling their potential as either cancer promoters or suppressors and also explores how both natural and synthetic compounds influence the SIRT function, indicating promise for therapeutic applications. We also discussed the inhibitors/activators tailored to specific SIRTs, holding potential for diseases lacking effective treatments. It may uncover the lesser-studied SIRT isoforms (e.g., SIRT6, SIRT7) and their unique functions. This article also offers a comprehensive overview of SIRTs, linking them to a spectrum of diseases and highlighting their potential for targeted therapies, combination approaches, disease management, and personalized medicine. We aim to contribute to a transformative era in healthcare and innovative treatments by unraveling the intricate functions of SIRTs.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Environmental changes</subject><subject>Enzymes</subject><subject>Humans</subject><subject>Isoforms</subject><subject>Medical treatment</subject><subject>Molecular Targeted Therapy</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - metabolism</subject><subject>Neurosciences</subject><subject>Pharmacology/Toxicology</subject><subject>Precision Medicine</subject><subject>Review</subject><subject>Sirtuins</subject><subject>Sirtuins - metabolism</subject><subject>Substrate preferences</subject><subject>Therapeutic applications</subject><issn>0028-1298</issn><issn>1432-1912</issn><issn>1432-1912</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtOwzAUhi0EouXyAgzIEgtLwJfYjtkQ4iYhMQALi-XYbuoqdYKdCPH2uLSAxMDk4Xzn938-AI4wOsMIifOEEMGoQKQsECWcFnILTHFJSYElJttgmudVgYmsJmAvpQVCiGPGdsGEVlJwVPIpeH3ycRh9gD4k38yHdAHr6G3jQwOHuYON7mHthnfnAjSubcdWR9jHzriUXII62BUWde_GwRuo-771Rg--C-kA7Mx0m9zh5t0HLzfXz1d3xcPj7f3V5UNhCONDwbBmTNqZxZYajqSt8y2aldgYKWtRlaWwhknuaqu5MJXNvGG4QkxrXglD98HpOjfXehtdGtTSp1VXHVw3JkWR4ILzipUZPfmDLroxhtxOUUwx50SUOFNkTZnYpRTdTPXRL3X8UBiplXm1Nq-yefVlXsm8dLyJHuulsz8r36ozQNdAyqPQuPj79z-xn8MWjtM</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Kamal, Shagufta</creator><creator>Babar, Sharon</creator><creator>Ali, Waqas</creator><creator>Rehman, Kanwal</creator><creator>Hussain, Amjad</creator><creator>Akash, Muhammad Sajid Hamid</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9446-5233</orcidid></search><sort><creationdate>202412</creationdate><title>Sirtuin insights: bridging the gap between cellular processes and therapeutic applications</title><author>Kamal, Shagufta ; Babar, Sharon ; Ali, Waqas ; Rehman, Kanwal ; Hussain, Amjad ; Akash, Muhammad Sajid Hamid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-51a559dfd1d3c609db326a541cc99b78447dc596ebda67c8d1a5c51805aa687c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Environmental changes</topic><topic>Enzymes</topic><topic>Humans</topic><topic>Isoforms</topic><topic>Medical treatment</topic><topic>Molecular Targeted Therapy</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - metabolism</topic><topic>Neurosciences</topic><topic>Pharmacology/Toxicology</topic><topic>Precision Medicine</topic><topic>Review</topic><topic>Sirtuins</topic><topic>Sirtuins - metabolism</topic><topic>Substrate preferences</topic><topic>Therapeutic applications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamal, Shagufta</creatorcontrib><creatorcontrib>Babar, Sharon</creatorcontrib><creatorcontrib>Ali, Waqas</creatorcontrib><creatorcontrib>Rehman, Kanwal</creatorcontrib><creatorcontrib>Hussain, Amjad</creatorcontrib><creatorcontrib>Akash, Muhammad Sajid Hamid</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamal, Shagufta</au><au>Babar, Sharon</au><au>Ali, Waqas</au><au>Rehman, Kanwal</au><au>Hussain, Amjad</au><au>Akash, Muhammad Sajid Hamid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sirtuin insights: bridging the gap between cellular processes and therapeutic applications</atitle><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle><stitle>Naunyn-Schmiedeberg's Arch Pharmacol</stitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><date>2024-12</date><risdate>2024</risdate><volume>397</volume><issue>12</issue><spage>9315</spage><epage>9344</epage><pages>9315-9344</pages><issn>0028-1298</issn><issn>1432-1912</issn><eissn>1432-1912</eissn><abstract>The greatest challenges that organisms face today are effective responses or detection of life-threatening environmental changes due to an obvious semblance of stress and metabolic fluctuations. These are associated with different pathological conditions among which cancer is most important. Sirtuins (SIRTs; NAD
+
-dependent enzymes) are versatile enzymes with diverse substrate preferences, cellular locations, crucial for cellular processes and pathological conditions. This article describes in detail the distinct roles of SIRT isoforms, unveiling their potential as either cancer promoters or suppressors and also explores how both natural and synthetic compounds influence the SIRT function, indicating promise for therapeutic applications. We also discussed the inhibitors/activators tailored to specific SIRTs, holding potential for diseases lacking effective treatments. It may uncover the lesser-studied SIRT isoforms (e.g., SIRT6, SIRT7) and their unique functions. This article also offers a comprehensive overview of SIRTs, linking them to a spectrum of diseases and highlighting their potential for targeted therapies, combination approaches, disease management, and personalized medicine. We aim to contribute to a transformative era in healthcare and innovative treatments by unraveling the intricate functions of SIRTs.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38976046</pmid><doi>10.1007/s00210-024-03263-9</doi><tpages>30</tpages><orcidid>https://orcid.org/0000-0002-9446-5233</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-1298 |
| ispartof | Naunyn-Schmiedeberg's archives of pharmacology, 2024-12, Vol.397 (12), p.9315-9344 |
| issn | 0028-1298 1432-1912 1432-1912 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3076766854 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Biomedical and Life Sciences Biomedicine Environmental changes Enzymes Humans Isoforms Medical treatment Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - metabolism Neurosciences Pharmacology/Toxicology Precision Medicine Review Sirtuins Sirtuins - metabolism Substrate preferences Therapeutic applications |
| title | Sirtuin insights: bridging the gap between cellular processes and therapeutic applications |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T20%3A52%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sirtuin%20insights:%20bridging%20the%20gap%20between%20cellular%20processes%20and%20therapeutic%20applications&rft.jtitle=Naunyn-Schmiedeberg's%20archives%20of%20pharmacology&rft.au=Kamal,%20Shagufta&rft.date=2024-12&rft.volume=397&rft.issue=12&rft.spage=9315&rft.epage=9344&rft.pages=9315-9344&rft.issn=0028-1298&rft.eissn=1432-1912&rft_id=info:doi/10.1007/s00210-024-03263-9&rft_dat=%3Cproquest_cross%3E3131662741%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3131662741&rft_id=info:pmid/38976046&rfr_iscdi=true |