Plasma as endothelial rescue in septic shock: A randomized, phase 2a pilot trial

Background Septic shock is associated with high morbidity and mortality, the endothelium plays an important role. Crystalloids is standard of care to maintain intravascular volume. Plasma is associated with improved endothelial integrity and restoration of the glycocalyx layer. We evaluated the effi...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2024-09, Vol.64 (9), p.1653-1661
Hauptverfasser:	Clausen, Niels E., Meyhoff, Christian S., Henriksen, Hanne H., Lindhardt, Anne, Pott, Frank C., Lunen, Thomas Bech, Gybel‐Brask, Mikkel, Lange, Theis, Johansson, Pär I., Stensballe, Jakob
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Aged Biomarkers crystalloids Endothelium Female Fluid Therapy glycocalyx Humans Isotonic Solutions - therapeutic use Male Microvasculature Middle Aged Morbidity Mortality Perfusion Pilot Projects Plasma Resuscitation Resuscitation - methods Sepsis Septic shock Shock, Septic - blood Shock, Septic - drug therapy Shock, Septic - therapy
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