Discovering interactions in polypharmacy: Impact of metamizole on the metabolism of quetiapine

Aims: Metamizole is quite an old drug with analgesic, antipyretic and spasmolytic properties. Recent findings have shown that it may induce several cytochrome P450 (CYP) enzymes, especially CYP3A4 and CYP2B6. The clinical relevance of these properties is uncertain. We aimed to unravel potential phar...

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Veröffentlicht in:	British journal of clinical pharmacology 2024-11, Vol.90 (11), p.2793-2801
Hauptverfasser:	Watermeyer, Fabian, Gaebler, Arnim Johannes, Neuner, Irene, Haen, Ekkehard, Hiemke, Christoph, Schoretsanitis, Georgios, Paulzen, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	cytochrome interaction metamizole pharmacokinetics quetiapine therapeutic drug monitoring
Online-Zugang:	Volltext
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