Inhibition of mast cell degranulation by novel small molecule MRGPRX2 antagonists

Mas-related G protein–coupled receptor X2 (MRGPRX2) is a promiscuous receptor on mast cells that mediates IgE-independent degranulation and has been implicated in multiple mast cell–mediated disorders, including chronic urticaria, atopic dermatitis, and pain disorders. Although it is a promising the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of allergy and clinical immunology 2024-10, Vol.154 (4), p.1033-1043
Hauptverfasser:	Wollam, Joshua, Solomon, Michelle, Villescaz, Christiane, Lanier, Marion, Evans, Samantha, Bacon, Corinne, Freeman, David, Vasquez, Alexis, Vest, Alan, Napora, Jim, Charlot, Brittney, Cavarlez, Christine, Kim, Andrew, Dvorak, Lisa, Selfridge, Brandon, Huang, Liming, Nevarez, Andres, Dedman, Harry, Brooks, Jennifer, Frischbutter, Stefan, Metz, Martin, Serhan, Nadine, Gaudenzio, Nicolas, Timony, Gregg, Martinborough, Esther, Boehm, Marcus F., Viswanath, Veena
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Degranulation - drug effects Cell Line degranulation Humans IgE independent Inflammation mast cells Mast Cells - drug effects Mast Cells - immunology Mice Mice, Inbred C57BL Mice, Knockout Nerve Tissue Proteins - genetics neuropeptides Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - genetics Receptors, Neuropeptide - antagonists & inhibitors Receptors, Neuropeptide - genetics sensory neurons skin Skin - drug effects Skin - immunology urticaria
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!