Immature platelet count responses of pediatric patients with immune-mediated thrombotic thrombocytopenic purpura

•A-IPC on admission of pediatric iTTP patients was depressed below reference range similar to adult patients.•Low A-IPC on admission predicted ADAMTS13 deficiency testing results.•A-IPC changes post TPE initiation indicated response to therapy.•A-IPC instability for cohort predicted presence of inhi...

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Veröffentlicht in:	Thrombosis research 2024-09, Vol.241, p.109085, Article 109085
Hauptverfasser:	Reeves, Hollie M., Zhu, Meng-Lei, Maitta, Robert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absolute immature platelet count ADAMTS13 Adolescent Blood Platelets - immunology Blood Platelets - pathology Child Child, Preschool Female Humans Inhibitor Male Negative feedback Pediatric Platelet Count Platelets Purpura, Thrombotic Thrombocytopenic - blood Purpura, Thrombotic Thrombocytopenic - immunology
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Zusammenfassung:	•A-IPC on admission of pediatric iTTP patients was depressed below reference range similar to adult patients.•Low A-IPC on admission predicted ADAMTS13 deficiency testing results.•A-IPC changes post TPE initiation indicated response to therapy.•A-IPC instability for cohort predicted presence of inhibitor and characterized therapy response.•PLT count decreases occurred simultaneously to A-IPC decreases while on therapy.
ISSN:	0049-3848 1879-2472 1879-2472
DOI:	10.1016/j.thromres.2024.109085