Nor-LAAM loaded PLGA microparticles for treating opioid use disorder

The treatment landscape for opioid use disorder (OUD) faces challenges stemming from the limited efficacy of existing medications, poor adherence to prescribed regimens, and a heightened risk of fatal overdose post-treatment cessation. Therefore, there is a pressing need for innovative therapeutic s...

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Veröffentlicht in:	Journal of controlled release 2024-09, Vol.373, p.93-104
Hauptverfasser:	Ingabire, Diane, Qin, Chaolong, Meng, Tuo, Raynold, Aji Alex Moothendathu, Sudarjat, Hadi, Townsend, E. Andrew, Pangeni, Rudra, Poudel, Sagun, Arriaga, Michelle, Zhao, Long, Chow, Woon N., Banks, Matthew, Xu, Qingguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - administration & dosage Analgesics, Opioid - pharmacokinetics Analgesics, Opioid - therapeutic use Animals Delayed-Action Preparations Drug abuse Drug Carriers - chemistry Drug Liberation Fentanyl-vs-food choice Hydrophobic ion pairing (HIP) Male Opioid-Related Disorders - drug therapy Particle Size Pharmacokinetics Polylactic Acid-Polyglycolic Acid Copolymer - chemistry Rats Rats, Sprague-Dawley Sustained delivery
Online-Zugang:	Volltext
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