miRNAs that regulate apoptosis in breast cancer and cervical cancer

In today’s world, one of the main problems is cancer, which still has a long way to go to cure it, and it brings a lot of financial and emotional costs to the people of society and governments. Breast cancer (BC) and cervical cancer (CC), two of the most common cancers, are caused by several genetic...

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Veröffentlicht in:Cell biochemistry and biophysics 2024-09, Vol.82 (3), p.1993-2006
Hauptverfasser: Beilankouhi, Elmira Aboutalebi Vand, Maghsoodi, Maral Salek, Sani, Maryam Zamani, Khosroshahi, Negin Sadi, Zarezadeh, Reza, Nargesi, Mirsaed Miri, Safaralizadeh, Reza, Valilo, Mohammad
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container_end_page 2006
container_issue 3
container_start_page 1993
container_title Cell biochemistry and biophysics
container_volume 82
creator Beilankouhi, Elmira Aboutalebi Vand
Maghsoodi, Maral Salek
Sani, Maryam Zamani
Khosroshahi, Negin Sadi
Zarezadeh, Reza
Nargesi, Mirsaed Miri
Safaralizadeh, Reza
Valilo, Mohammad
description In today’s world, one of the main problems is cancer, which still has a long way to go to cure it, and it brings a lot of financial and emotional costs to the people of society and governments. Breast cancer (BC) and cervical cancer (CC), two of the most common cancers, are caused by several genetic and environmental factors in women. These two cancers’ involvement rate is higher than other cancers in women. microRNAs (miRNAs) are non-coding RNA molecules with a length of 18 to 24 nucleotides, which play an important role in post-translational changes. miRNAs themselves are divided into two categories, oncomiRs and tumor suppressors. OncomiRs have a part in tumor expansion and tumor suppressors prevent tumor development and progress. miRNAs can control cellular processes by regulating various pathways including autophagy, apoptosis, and signaling. Apoptosis is a type of programmed cell death that includes intrinsic and extrinsic pathways and is different from other cell death pathways such as necrosis and ferroptosis. Apoptosis controls the growth, differentiation, and death of cells by regulating the death of damaged and old cells, and since miRNAs are one of the factors that regulate apoptosis, and divided into two categories: pro-apoptotic and anti-apoptotic. We decided in this study to investigate the relationship between miRNAs and apoptosis in the most common women’s cancers, BC and CC.
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subjects Apoptosis
Autophagy
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biotechnology
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cell Biology
Cell death
Cell differentiation
Cervical cancer
Environmental factors
Female
Ferroptosis
Gene Expression Regulation, Neoplastic
Humans
Life Sciences
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Mortality
Necrosis
Nucleotides
Pharmacology/Toxicology
Post-translation
Review Paper
Suppressors
Tumors
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - metabolism
Uterine Cervical Neoplasms - pathology
Womens health
title miRNAs that regulate apoptosis in breast cancer and cervical cancer
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