Epigenetic recording of stimulation history reveals BLIMP1–BACH2 balance in determining memory B cell fate upon recall challenge

Memory B cells (MBCs) differentiate into plasma cells (PCs) or germinal centers (GCs) upon antigen recall. How this decision is programmed is not understood. We found that the relative strength between two antagonistic transcription factors, B lymphocyte-induced maturation protein 1 (BLIMP1) and BTB...

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Veröffentlicht in:	Nature immunology 2024-08, Vol.25 (8), p.1432-1444
Hauptverfasser:	Shao, Wen, Wang, Yifeng, Fang, Qian, Shi, Wenjuan, Qi, Hai
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2152/2153/1571 631/250/2502/2170 Animals Antigens Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism Biomedical and Life Sciences Biomedicine CD40 antigen Cell Differentiation Cell fate Chromatin Epigenesis, Genetic Epigenetics Germinal Center - immunology Germinal Center - metabolism Germinal centers Immunologic Memory Immunological memory Immunology Infectious Diseases Interferon Interferon regulatory factor Interferon regulatory factor 4 Interferon Regulatory Factors - genetics Interferon Regulatory Factors - metabolism Lymphocyte Activation - genetics Lymphocytes Lymphocytes B Maturation Memory B Cells - immunology Memory B Cells - metabolism Memory cells Mice Mice, Inbred C57BL Plasma cells Plasma Cells - immunology Plasma Cells - metabolism Positive Regulatory Domain I-Binding Factor 1 - genetics Positive Regulatory Domain I-Binding Factor 1 - metabolism Regulatory sequences Signal Transduction Transcription factors
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