Mapping the lung fibrosis transcriptome of mice and men
Idiopathic pulmonary fibrosis (IPF), a deadly lung disease of unclear etiology, lacks sufficient therapeutic options. We extensively mapped the spatial transcriptomes of patient lungs and made translational comparisons with a mouse model of lung fibrosis, providing insights into disease mechanisms a...
Gespeichert in:
| Veröffentlicht in: | Nature genetics 2024-08, Vol.56 (8), p.1550-1551 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1551 |
|---|---|
| container_issue | 8 |
| container_start_page | 1550 |
| container_title | Nature genetics |
| container_volume | 56 |
| creator | Franzén, Lovisa Ståhl, Patrik L |
| description | Idiopathic pulmonary fibrosis (IPF), a deadly lung disease of unclear etiology, lacks sufficient therapeutic options. We extensively mapped the spatial transcriptomes of patient lungs and made translational comparisons with a mouse model of lung fibrosis, providing insights into disease mechanisms and the utility of the animal model for drug discovery. |
| doi_str_mv | 10.1038/s41588-024-01833-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3076285949</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3097913157</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-c242c5f34b1d52a963e2ca59f4174050c440ef2b5c7c76bbfb623c691fea79f53</originalsourceid><addsrcrecordid>eNp9kLlOAzEQhi0EIiHwAhRoJRqaBd9HiSIuKYgGasvr2MHRXti7BW-PYQNIFDT2SP7mn_EHwCmClwgSeZUoYlKWENMSIklISffAHDHKSySQ3M815KikkPAZOEppCyGiFMpDMCNScSUJmwPxaPo-tJtieHVFPebChyp2KaRiiKZNNoZ-6BpXdL5ognWFaddF49pjcOBNndzJ7l6Al9ub5-V9uXq6e1her0qLGR_ySbFlntAKrRk2ihOHrWHKUyQoZNDmhZzHFbPCCl5VvuKYWK6Qd0Yoz8gCXEy5fezeRpcG3YRkXV2b1nVj0gQKjiVTVGX0_A-67cbY5u0ypYRCBDGRKTxRNv8yRed1H0Nj4rtGUH9q1ZNWnbXqL62a5qazXfRYNW790_LtMQNkAlJ-ajcu_s7-J_YDZiOBGQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3097913157</pqid></control><display><type>article</type><title>Mapping the lung fibrosis transcriptome of mice and men</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Nature</source><creator>Franzén, Lovisa ; Ståhl, Patrik L</creator><creatorcontrib>Franzén, Lovisa ; Ståhl, Patrik L</creatorcontrib><description>Idiopathic pulmonary fibrosis (IPF), a deadly lung disease of unclear etiology, lacks sufficient therapeutic options. We extensively mapped the spatial transcriptomes of patient lungs and made translational comparisons with a mouse model of lung fibrosis, providing insights into disease mechanisms and the utility of the animal model for drug discovery.</description><identifier>ISSN: 1061-4036</identifier><identifier>ISSN: 1546-1718</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/s41588-024-01833-4</identifier><identifier>PMID: 38969835</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/208/199 ; 631/337/2019 ; 692/699/1785 ; Agriculture ; Animal Genetics and Genomics ; Animal models ; Animals ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Bleomycin ; Cancer Research ; Cells ; Disease ; Fibrosis ; Gene Function ; Human Genetics ; Humans ; Lung - metabolism ; Lung - pathology ; Lung diseases ; Lungs ; Mice ; Pathogenesis ; Pathophysiology ; Pulmonary fibrosis ; Pulmonary Fibrosis - genetics ; R&D ; Research & development ; Research Briefing ; Spatial discrimination ; Spatial resolution ; Transcriptome - genetics ; Transcriptomes ; Transcriptomics</subject><ispartof>Nature genetics, 2024-08, Vol.56 (8), p.1550-1551</ispartof><rights>Springer Nature America, Inc. 2024</rights><rights>Copyright Nature Publishing Group Aug 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-c242c5f34b1d52a963e2ca59f4174050c440ef2b5c7c76bbfb623c691fea79f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41588-024-01833-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41588-024-01833-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38969835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Franzén, Lovisa</creatorcontrib><creatorcontrib>Ståhl, Patrik L</creatorcontrib><title>Mapping the lung fibrosis transcriptome of mice and men</title><title>Nature genetics</title><addtitle>Nat Genet</addtitle><addtitle>Nat Genet</addtitle><description>Idiopathic pulmonary fibrosis (IPF), a deadly lung disease of unclear etiology, lacks sufficient therapeutic options. We extensively mapped the spatial transcriptomes of patient lungs and made translational comparisons with a mouse model of lung fibrosis, providing insights into disease mechanisms and the utility of the animal model for drug discovery.</description><subject>631/208/199</subject><subject>631/337/2019</subject><subject>692/699/1785</subject><subject>Agriculture</subject><subject>Animal Genetics and Genomics</subject><subject>Animal models</subject><subject>Animals</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bleomycin</subject><subject>Cancer Research</subject><subject>Cells</subject><subject>Disease</subject><subject>Fibrosis</subject><subject>Gene Function</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Lung - metabolism</subject><subject>Lung - pathology</subject><subject>Lung diseases</subject><subject>Lungs</subject><subject>Mice</subject><subject>Pathogenesis</subject><subject>Pathophysiology</subject><subject>Pulmonary fibrosis</subject><subject>Pulmonary Fibrosis - genetics</subject><subject>R&D</subject><subject>Research & development</subject><subject>Research Briefing</subject><subject>Spatial discrimination</subject><subject>Spatial resolution</subject><subject>Transcriptome - genetics</subject><subject>Transcriptomes</subject><subject>Transcriptomics</subject><issn>1061-4036</issn><issn>1546-1718</issn><issn>1546-1718</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLlOAzEQhi0EIiHwAhRoJRqaBd9HiSIuKYgGasvr2MHRXti7BW-PYQNIFDT2SP7mn_EHwCmClwgSeZUoYlKWENMSIklISffAHDHKSySQ3M815KikkPAZOEppCyGiFMpDMCNScSUJmwPxaPo-tJtieHVFPebChyp2KaRiiKZNNoZ-6BpXdL5ognWFaddF49pjcOBNndzJ7l6Al9ub5-V9uXq6e1her0qLGR_ySbFlntAKrRk2ihOHrWHKUyQoZNDmhZzHFbPCCl5VvuKYWK6Qd0Yoz8gCXEy5fezeRpcG3YRkXV2b1nVj0gQKjiVTVGX0_A-67cbY5u0ypYRCBDGRKTxRNv8yRed1H0Nj4rtGUH9q1ZNWnbXqL62a5qazXfRYNW790_LtMQNkAlJ-ajcu_s7-J_YDZiOBGQ</recordid><startdate>202408</startdate><enddate>202408</enddate><creator>Franzén, Lovisa</creator><creator>Ståhl, Patrik L</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>202408</creationdate><title>Mapping the lung fibrosis transcriptome of mice and men</title><author>Franzén, Lovisa ; Ståhl, Patrik L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-c242c5f34b1d52a963e2ca59f4174050c440ef2b5c7c76bbfb623c691fea79f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>631/208/199</topic><topic>631/337/2019</topic><topic>692/699/1785</topic><topic>Agriculture</topic><topic>Animal Genetics and Genomics</topic><topic>Animal models</topic><topic>Animals</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bleomycin</topic><topic>Cancer Research</topic><topic>Cells</topic><topic>Disease</topic><topic>Fibrosis</topic><topic>Gene Function</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Lung - metabolism</topic><topic>Lung - pathology</topic><topic>Lung diseases</topic><topic>Lungs</topic><topic>Mice</topic><topic>Pathogenesis</topic><topic>Pathophysiology</topic><topic>Pulmonary fibrosis</topic><topic>Pulmonary Fibrosis - genetics</topic><topic>R&D</topic><topic>Research & development</topic><topic>Research Briefing</topic><topic>Spatial discrimination</topic><topic>Spatial resolution</topic><topic>Transcriptome - genetics</topic><topic>Transcriptomes</topic><topic>Transcriptomics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Franzén, Lovisa</creatorcontrib><creatorcontrib>Ståhl, Patrik L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Franzén, Lovisa</au><au>Ståhl, Patrik L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mapping the lung fibrosis transcriptome of mice and men</atitle><jtitle>Nature genetics</jtitle><stitle>Nat Genet</stitle><addtitle>Nat Genet</addtitle><date>2024-08</date><risdate>2024</risdate><volume>56</volume><issue>8</issue><spage>1550</spage><epage>1551</epage><pages>1550-1551</pages><issn>1061-4036</issn><issn>1546-1718</issn><eissn>1546-1718</eissn><abstract>Idiopathic pulmonary fibrosis (IPF), a deadly lung disease of unclear etiology, lacks sufficient therapeutic options. We extensively mapped the spatial transcriptomes of patient lungs and made translational comparisons with a mouse model of lung fibrosis, providing insights into disease mechanisms and the utility of the animal model for drug discovery.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>38969835</pmid><doi>10.1038/s41588-024-01833-4</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1061-4036 |
| ispartof | Nature genetics, 2024-08, Vol.56 (8), p.1550-1551 |
| issn | 1061-4036 1546-1718 1546-1718 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3076285949 |
| source | MEDLINE; SpringerLink Journals; Nature |
| subjects | 631/208/199 631/337/2019 692/699/1785 Agriculture Animal Genetics and Genomics Animal models Animals Biomarkers Biomedical and Life Sciences Biomedicine Bleomycin Cancer Research Cells Disease Fibrosis Gene Function Human Genetics Humans Lung - metabolism Lung - pathology Lung diseases Lungs Mice Pathogenesis Pathophysiology Pulmonary fibrosis Pulmonary Fibrosis - genetics R&D Research & development Research Briefing Spatial discrimination Spatial resolution Transcriptome - genetics Transcriptomes Transcriptomics |
| title | Mapping the lung fibrosis transcriptome of mice and men |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T12%3A11%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mapping%20the%20lung%20fibrosis%20transcriptome%20of%20mice%20and%20men&rft.jtitle=Nature%20genetics&rft.au=Franz%C3%A9n,%20Lovisa&rft.date=2024-08&rft.volume=56&rft.issue=8&rft.spage=1550&rft.epage=1551&rft.pages=1550-1551&rft.issn=1061-4036&rft.eissn=1546-1718&rft_id=info:doi/10.1038/s41588-024-01833-4&rft_dat=%3Cproquest_cross%3E3097913157%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3097913157&rft_id=info:pmid/38969835&rfr_iscdi=true |