Autistic traits in youth with familial adenomatous polyposis: A Dutch–Canadian case–control study
This study investigated the neurodevelopmental impact of pathogenic adenomatous polyposis coli (APC) gene variants in patients with familial adenomatous polyposis (FAP), a cancer predisposition syndrome. We hypothesized that certain pathogenic APC variants result in behavioral–cognitive challenges....
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| Veröffentlicht in: | American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2024-12, Vol.195 (8), p.e32999-n/a |
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| creator | Danieli, Polina Perlman Hoang, Ny Selvanayagam, Thanuja Yang, Alvin Breetvelt, Elemi Tabbers, Merit Cohen, Christine Aelvoet, Arthur S. Trost, Brett Ward, Thomas Semotiuk, Kara Durno, Carol Aronson, Melyssa Cohen, Zane Dekker, Evelien Vorstman, Jacob |
| description | This study investigated the neurodevelopmental impact of pathogenic adenomatous polyposis coli (APC) gene variants in patients with familial adenomatous polyposis (FAP), a cancer predisposition syndrome. We hypothesized that certain pathogenic APC variants result in behavioral–cognitive challenges. We compared 66 FAP patients (cases) and 34 unaffected siblings (controls) to explore associations between APC variants and behavioral and cognitive challenges. Our findings indicate that FAP patients exhibited higher Social Responsiveness Scale (SRS) scores, suggesting a greater prevalence of autistic traits when compared to unaffected siblings (mean 53.8 vs. 47.4, Wilcoxon p = 0.018). The distribution of SRS scores in cases suggested a bimodal pattern, potentially linked to the location of the APC variant, with scores increasing from the 5′ to 3′ end of the gene (Pearson's r = 0.33, p = 0.022). While we observed a trend toward lower educational attainment in cases, this difference was not statistically significant. This study is the first to explore the connection between APC variant location and neurodevelopmental traits in FAP, expanding our understanding of the genotype–phenotype correlation. Our results emphasize the importance of clinical assessment for autistic traits in FAP patients, shedding light on the potential role of APC gene variants in these behavioral and cognitive challenges. |
| doi_str_mv | 10.1002/ajmg.b.32999 |
| format | Article |
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We hypothesized that certain pathogenic APC variants result in behavioral–cognitive challenges. We compared 66 FAP patients (cases) and 34 unaffected siblings (controls) to explore associations between APC variants and behavioral and cognitive challenges. Our findings indicate that FAP patients exhibited higher Social Responsiveness Scale (SRS) scores, suggesting a greater prevalence of autistic traits when compared to unaffected siblings (mean 53.8 vs. 47.4, Wilcoxon p = 0.018). The distribution of SRS scores in cases suggested a bimodal pattern, potentially linked to the location of the APC variant, with scores increasing from the 5′ to 3′ end of the gene (Pearson's r = 0.33, p = 0.022). While we observed a trend toward lower educational attainment in cases, this difference was not statistically significant. This study is the first to explore the connection between APC variant location and neurodevelopmental traits in FAP, expanding our understanding of the genotype–phenotype correlation. Our results emphasize the importance of clinical assessment for autistic traits in FAP patients, shedding light on the potential role of APC gene variants in these behavioral and cognitive challenges.</description><identifier>ISSN: 1552-4841</identifier><identifier>ISSN: 1552-485X</identifier><identifier>EISSN: 1552-485X</identifier><identifier>DOI: 10.1002/ajmg.b.32999</identifier><identifier>PMID: 38967411</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adenomatous polyposis coli ; Adenomatous Polyposis Coli - genetics ; Adenomatous Polyposis Coli Protein - genetics ; Adolescent ; APC ; APC gene ; Autism ; Autistic Disorder - genetics ; Canada ; Case-Control Studies ; Child ; colon cancer ; Colorectal cancer ; Familial adenomatous polyposis ; Female ; Genetic Association Studies - methods ; Genetic disorders ; Genetic Predisposition to Disease ; Genotypes ; Humans ; Male ; Netherlands ; Phenotype ; Phenotypes ; pleiotropy ; Polyposis coli ; Polyps ; Siblings ; Social Responsiveness Scale ; Statistical analysis</subject><ispartof>American journal of medical genetics. 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Part B, Neuropsychiatric genetics</title><addtitle>Am J Med Genet B Neuropsychiatr Genet</addtitle><description>This study investigated the neurodevelopmental impact of pathogenic adenomatous polyposis coli (APC) gene variants in patients with familial adenomatous polyposis (FAP), a cancer predisposition syndrome. We hypothesized that certain pathogenic APC variants result in behavioral–cognitive challenges. We compared 66 FAP patients (cases) and 34 unaffected siblings (controls) to explore associations between APC variants and behavioral and cognitive challenges. Our findings indicate that FAP patients exhibited higher Social Responsiveness Scale (SRS) scores, suggesting a greater prevalence of autistic traits when compared to unaffected siblings (mean 53.8 vs. 47.4, Wilcoxon p = 0.018). The distribution of SRS scores in cases suggested a bimodal pattern, potentially linked to the location of the APC variant, with scores increasing from the 5′ to 3′ end of the gene (Pearson's r = 0.33, p = 0.022). While we observed a trend toward lower educational attainment in cases, this difference was not statistically significant. This study is the first to explore the connection between APC variant location and neurodevelopmental traits in FAP, expanding our understanding of the genotype–phenotype correlation. 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Part B, Neuropsychiatric genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Danieli, Polina Perlman</au><au>Hoang, Ny</au><au>Selvanayagam, Thanuja</au><au>Yang, Alvin</au><au>Breetvelt, Elemi</au><au>Tabbers, Merit</au><au>Cohen, Christine</au><au>Aelvoet, Arthur S.</au><au>Trost, Brett</au><au>Ward, Thomas</au><au>Semotiuk, Kara</au><au>Durno, Carol</au><au>Aronson, Melyssa</au><au>Cohen, Zane</au><au>Dekker, Evelien</au><au>Vorstman, Jacob</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autistic traits in youth with familial adenomatous polyposis: A Dutch–Canadian case–control study</atitle><jtitle>American journal of medical genetics. 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Our findings indicate that FAP patients exhibited higher Social Responsiveness Scale (SRS) scores, suggesting a greater prevalence of autistic traits when compared to unaffected siblings (mean 53.8 vs. 47.4, Wilcoxon p = 0.018). The distribution of SRS scores in cases suggested a bimodal pattern, potentially linked to the location of the APC variant, with scores increasing from the 5′ to 3′ end of the gene (Pearson's r = 0.33, p = 0.022). While we observed a trend toward lower educational attainment in cases, this difference was not statistically significant. This study is the first to explore the connection between APC variant location and neurodevelopmental traits in FAP, expanding our understanding of the genotype–phenotype correlation. 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| subjects | Adenomatous polyposis coli Adenomatous Polyposis Coli - genetics Adenomatous Polyposis Coli Protein - genetics Adolescent APC APC gene Autism Autistic Disorder - genetics Canada Case-Control Studies Child colon cancer Colorectal cancer Familial adenomatous polyposis Female Genetic Association Studies - methods Genetic disorders Genetic Predisposition to Disease Genotypes Humans Male Netherlands Phenotype Phenotypes pleiotropy Polyposis coli Polyps Siblings Social Responsiveness Scale Statistical analysis |
| title | Autistic traits in youth with familial adenomatous polyposis: A Dutch–Canadian case–control study |
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