E3 ubiquitin ligase RNF128 attenuates colitis and colorectal tumorigenesis by triggering the degradation of IL-6 receptors

[Display omitted] •Rnf128 deficiency raises the risk of colitis and increases the tumor burden in CRC induced by AOM/DSS or APC mutation.•RNF128 interacts with IL-6Rα and gp130 and mediated their lysosomal degradation in an E3 ligase activity-dependent manner.•RNF128 promoted K48-linked polyubiquiti...

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Veröffentlicht in:	Journal of advanced research 2024-07
Hauptverfasser:	He, Tian-Sheng, Cai, Kuntai, Lai, Weiling, Yu, Jingge, Qing, Furong, Shen, Ao, Sui, Lina, He, Wenji, Wang, Weihua, Xiao, Qiuxiang, Lei, Xiong, Guo, Tianfu, Liu, Zhiping
Format:	Artikel
Sprache:	eng
Schlagworte:	Colitis Colorectal cancer IL-6-STAT3 Inflammatory damage RNF128
Online-Zugang:	Volltext
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