A rapid LC-MS/MS method for the simultaneous quantification of ivacaftor, lumacaftor, elexacaftor, tezacaftor, hexyl-methyl ivacaftor and ivacaftor carboxylate in human plasma

Cystic fibrosis is one of the most common genetic diseases among caucasian population. This disease is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene encoding for the CFTR protein. Lumacaftor, elexacaftor, tezacaftor, and ivacaftor were currently used as t...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2024-09, Vol.248, p.116322, Article 116322
Hauptverfasser:	Zheng, Yi, Rouillon, Steeve, Khemakhem, Mohamed, Balakirouchenane, David, Lui, Gabrielle, Abdalla, Seef, Sanoufi, Mohammed Rohi, Sauvaitre, Lucie, Thebault, Laure, Hirt, Déborah, Treluyer, Jean-Marc, Gana, Inès, Benaboud, Sihem, Froelicher-bournaud, Léo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminophenols - blood Aminophenols - pharmacokinetics Aminopyridines - blood Aminopyridines - pharmacokinetics Benzodioxoles - blood Benzodioxoles - pharmacokinetics CFTR modulators Cystic fibrosis Cystic Fibrosis - blood Cystic Fibrosis - drug therapy Cystic Fibrosis Transmembrane Conductance Regulator - genetics Drug Monitoring - methods Humans Indoles - blood Indoles - pharmacokinetics LC-MS/MS Liquid Chromatography-Mass Spectrometry Pyrazoles - blood Pyrazoles - pharmacokinetics Pyridines Pyrroles - blood Pyrroles - pharmacokinetics Pyrrolidines Quinolones - blood Quinolones - pharmacokinetics Reproducibility of Results Tandem Mass Spectrometry - methods Therapeutic drug monitoring
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