Sophoricoside ameliorates methicillin-resistant Staphylococcus aureus-induced acute lung injury by inhibiting Bach1/Akt pathway

The lack of effective treatments for methicillin-resistant Staphylococcus aureus (MRSA) infection, which often leads to severe acute lung injury (ALI), poses a grave threat to human life. Sophoricoside (SOP), an isoflavone glycoside abundant in the fruit of traditional Chinese herbal Sophora japonic...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2024-09, Vol.132, p.155846, Article 155846
Hauptverfasser:	Wu, Yaxian, He, Shuai, Zhang, Yaru, Li, Shuaichao, Liu, Ruyin, Zhang, Yanli, Jing, Yutong, Chen, Dan, Tong, Ying, Wang, Zhiqiang, Wang, Qianyun, Pang, Qingfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lung injury Acute Lung Injury - drug therapy Acute Lung Injury - microbiology Akt Animals Anti-Inflammatory Agents - pharmacology atopic dermatitis Bach1 Benzopyrans cytokines Disease Models, Animal flow cytometry fruits glycosides histology humans inflammation isoflavones lipoteichoic acids Lung - drug effects Lung - pathology lungs Macrophage macrophage activation macrophages Macrophages - drug effects Male methicillin-resistant Staphylococcus aureus Methicillin-Resistant Staphylococcus aureus - drug effects Mice Mice, Inbred C57BL Mice, Knockout MRSA neutrophils non-specific serine/threonine protein kinase oxidative stress phosphorylation protective effect Proto-Oncogene Proteins c-akt - metabolism quantitative polymerase chain reaction RAW 264.7 Cells Signal Transduction - drug effects Sophoricoside Staphylococcal Infections - drug therapy Styphnolobium japonicum therapeutics
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