My 50-Plus Years of Academic Research Collaborations with Industry. A Retrospective
A retrospective is presented highlighting the synthesis of selected “first-in-kind” natural products, their synthetic analogues, structure elucidations, and rationally designed bioactive synthetic compounds that were accomplished because of collaborations with past and present pharmaceutical and agr...
Gespeichert in:
| Veröffentlicht in: | Journal of organic chemistry 2024-07, Vol.89 (13), p.9147-9186 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 9186 |
|---|---|
| container_issue | 13 |
| container_start_page | 9147 |
| container_title | Journal of organic chemistry |
| container_volume | 89 |
| creator | Hanessian, Stephen |
| description | A retrospective is presented highlighting the synthesis of selected “first-in-kind” natural products, their synthetic analogues, structure elucidations, and rationally designed bioactive synthetic compounds that were accomplished because of collaborations with past and present pharmaceutical and agrochemical companies. Medicinal chemistry projects involving structure-based design exploiting cocrystal structures of small molecules with biologically relevant enzymes, receptors, and bacterial ribosomes with synthetic small molecules leading to marketed products, clinical candidates, and novel drug prototypes were realized in collaboration. Personal reflections, historical insights, behind the scenes stories from various long-term projects are shared in this retrospective article. |
| doi_str_mv | 10.1021/acs.joc.4c00652 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3076016629</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3076016629</sourcerecordid><originalsourceid>FETCH-LOGICAL-a217t-996ee85d01042659cce6e32e248c969e10909f6c84c3267407ebb6dd97cea3a53</originalsourceid><addsrcrecordid>eNp1kMtLxDAQh4Mo7vo4e5McBWl3kjZpc1wWHwsrio-Dp5KmU7ZLH2vSKvvfG-nqzbkMDN_8mPkIuWAQMuBspo0LN50JYwMgBT8gUyY4BFJBfEimAJwHEZfRhJw4twFfQohjMonSVAom1JS8POyogOCpHhx9R20d7Uo6N7rApjL0GZ2fmTVddHWt887qvupaR7-qfk2XbTG43u5COvdgbzu3RdNXn3hGjkpdOzzf91PydnvzurgPVo93y8V8FWjOkj5QSiKmogAGMZdCGYMSI448To2SChkoUKU0aWz8D0kMCea5LAqVGNSRFtEpuRpzt7b7GND1WVM5g_7SFrvBZREkEpiUXHl0NqLGn-ksltnWVo22u4xB9mMy8yYzbzLbm_Qbl_vwIW-w-ON_1XngegTGzcG2_td_474B1YV9WQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3076016629</pqid></control><display><type>article</type><title>My 50-Plus Years of Academic Research Collaborations with Industry. A Retrospective</title><source>MEDLINE</source><source>ACS Publications</source><creator>Hanessian, Stephen</creator><creatorcontrib>Hanessian, Stephen</creatorcontrib><description>A retrospective is presented highlighting the synthesis of selected “first-in-kind” natural products, their synthetic analogues, structure elucidations, and rationally designed bioactive synthetic compounds that were accomplished because of collaborations with past and present pharmaceutical and agrochemical companies. Medicinal chemistry projects involving structure-based design exploiting cocrystal structures of small molecules with biologically relevant enzymes, receptors, and bacterial ribosomes with synthetic small molecules leading to marketed products, clinical candidates, and novel drug prototypes were realized in collaboration. Personal reflections, historical insights, behind the scenes stories from various long-term projects are shared in this retrospective article.</description><identifier>ISSN: 0022-3263</identifier><identifier>ISSN: 1520-6904</identifier><identifier>EISSN: 1520-6904</identifier><identifier>DOI: 10.1021/acs.joc.4c00652</identifier><identifier>PMID: 38865159</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Biological Products - chemical synthesis ; Biological Products - chemistry ; Chemistry, Pharmaceutical ; Drug Industry ; History, 20th Century ; History, 21st Century</subject><ispartof>Journal of organic chemistry, 2024-07, Vol.89 (13), p.9147-9186</ispartof><rights>2024 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-a217t-996ee85d01042659cce6e32e248c969e10909f6c84c3267407ebb6dd97cea3a53</cites><orcidid>0000-0003-3582-6972</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.joc.4c00652$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.joc.4c00652$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2763,27074,27922,27923,56736,56786</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38865159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hanessian, Stephen</creatorcontrib><title>My 50-Plus Years of Academic Research Collaborations with Industry. A Retrospective</title><title>Journal of organic chemistry</title><addtitle>J. Org. Chem</addtitle><description>A retrospective is presented highlighting the synthesis of selected “first-in-kind” natural products, their synthetic analogues, structure elucidations, and rationally designed bioactive synthetic compounds that were accomplished because of collaborations with past and present pharmaceutical and agrochemical companies. Medicinal chemistry projects involving structure-based design exploiting cocrystal structures of small molecules with biologically relevant enzymes, receptors, and bacterial ribosomes with synthetic small molecules leading to marketed products, clinical candidates, and novel drug prototypes were realized in collaboration. Personal reflections, historical insights, behind the scenes stories from various long-term projects are shared in this retrospective article.</description><subject>Biological Products - chemical synthesis</subject><subject>Biological Products - chemistry</subject><subject>Chemistry, Pharmaceutical</subject><subject>Drug Industry</subject><subject>History, 20th Century</subject><subject>History, 21st Century</subject><issn>0022-3263</issn><issn>1520-6904</issn><issn>1520-6904</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtLxDAQh4Mo7vo4e5McBWl3kjZpc1wWHwsrio-Dp5KmU7ZLH2vSKvvfG-nqzbkMDN_8mPkIuWAQMuBspo0LN50JYwMgBT8gUyY4BFJBfEimAJwHEZfRhJw4twFfQohjMonSVAom1JS8POyogOCpHhx9R20d7Uo6N7rApjL0GZ2fmTVddHWt887qvupaR7-qfk2XbTG43u5COvdgbzu3RdNXn3hGjkpdOzzf91PydnvzurgPVo93y8V8FWjOkj5QSiKmogAGMZdCGYMSI448To2SChkoUKU0aWz8D0kMCea5LAqVGNSRFtEpuRpzt7b7GND1WVM5g_7SFrvBZREkEpiUXHl0NqLGn-ksltnWVo22u4xB9mMy8yYzbzLbm_Qbl_vwIW-w-ON_1XngegTGzcG2_td_474B1YV9WQ</recordid><startdate>20240705</startdate><enddate>20240705</enddate><creator>Hanessian, Stephen</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3582-6972</orcidid></search><sort><creationdate>20240705</creationdate><title>My 50-Plus Years of Academic Research Collaborations with Industry. A Retrospective</title><author>Hanessian, Stephen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a217t-996ee85d01042659cce6e32e248c969e10909f6c84c3267407ebb6dd97cea3a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biological Products - chemical synthesis</topic><topic>Biological Products - chemistry</topic><topic>Chemistry, Pharmaceutical</topic><topic>Drug Industry</topic><topic>History, 20th Century</topic><topic>History, 21st Century</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hanessian, Stephen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of organic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hanessian, Stephen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>My 50-Plus Years of Academic Research Collaborations with Industry. A Retrospective</atitle><jtitle>Journal of organic chemistry</jtitle><addtitle>J. Org. Chem</addtitle><date>2024-07-05</date><risdate>2024</risdate><volume>89</volume><issue>13</issue><spage>9147</spage><epage>9186</epage><pages>9147-9186</pages><issn>0022-3263</issn><issn>1520-6904</issn><eissn>1520-6904</eissn><abstract>A retrospective is presented highlighting the synthesis of selected “first-in-kind” natural products, their synthetic analogues, structure elucidations, and rationally designed bioactive synthetic compounds that were accomplished because of collaborations with past and present pharmaceutical and agrochemical companies. Medicinal chemistry projects involving structure-based design exploiting cocrystal structures of small molecules with biologically relevant enzymes, receptors, and bacterial ribosomes with synthetic small molecules leading to marketed products, clinical candidates, and novel drug prototypes were realized in collaboration. Personal reflections, historical insights, behind the scenes stories from various long-term projects are shared in this retrospective article.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>38865159</pmid><doi>10.1021/acs.joc.4c00652</doi><tpages>40</tpages><orcidid>https://orcid.org/0000-0003-3582-6972</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3263 |
| ispartof | Journal of organic chemistry, 2024-07, Vol.89 (13), p.9147-9186 |
| issn | 0022-3263 1520-6904 1520-6904 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3076016629 |
| source | MEDLINE; ACS Publications |
| subjects | Biological Products - chemical synthesis Biological Products - chemistry Chemistry, Pharmaceutical Drug Industry History, 20th Century History, 21st Century |
| title | My 50-Plus Years of Academic Research Collaborations with Industry. A Retrospective |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T23%3A43%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=My%2050-Plus%20Years%20of%20Academic%20Research%20Collaborations%20with%20Industry.%20A%20Retrospective&rft.jtitle=Journal%20of%20organic%20chemistry&rft.au=Hanessian,%20Stephen&rft.date=2024-07-05&rft.volume=89&rft.issue=13&rft.spage=9147&rft.epage=9186&rft.pages=9147-9186&rft.issn=0022-3263&rft.eissn=1520-6904&rft_id=info:doi/10.1021/acs.joc.4c00652&rft_dat=%3Cproquest_cross%3E3076016629%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3076016629&rft_id=info:pmid/38865159&rfr_iscdi=true |