Long-term outcome of invasive pure micropapillary breast cancer compared with invasive mixed micropapillary and invasive ductal breast cancer: a matched retrospective study
Purpose Data on the prognostic impact of the micropapillary component in breast cancer are limited. The purpose of this study was to investigate the clinicopathological characteristics and long-term outcomes of pure and mixed invasive micropapillary breast cancer (IMPC) patients compared to invasive...
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| creator | Magnoni, Francesca Bianchi, Beatrice Pagan, Eleonora Corso, Giovanni Sala, Isabella Bagnardi, Vincenzo Claudia, Sangalli Brancaccio, Roberta Bottazzoli, Elisa Boato, Antony Munzone, Elisabetta Dellapasqua, Silvia Fusco, Nicola Viviana, Galimberti Veronesi, Paolo |
| description | Purpose
Data on the prognostic impact of the micropapillary component in breast cancer are limited. The purpose of this study was to investigate the clinicopathological characteristics and long-term outcomes of pure and mixed invasive micropapillary breast cancer (IMPC) patients compared to invasive ductal cancer (IDC) patients.
Methods
This retrospective study analysed all IMPC and IDC patients treated at the European Institute of Oncology (IEO) between 1997 and 2019. The overall cohort of IMPC patients was divided in two groups, pure and mixed IMPC. Each patient with mixed or pure IMPC was matched with one patient with IDC, based on year of surgery, age, pT, pN, and molecular subtype.
Results
A total of 30,115 IDC, 120 pure IMPC and 150 mixed IMPC patients were considered eligible. Compared to IDC, pure and mixed IMPC patients presented a higher rate of locally advanced disease (pT2-T3, pN2-N3), vascular invasion, and Luminal B subtype. After matching, pure and mixed IMPC showed a significant higher rate of vascular invasion compared to IDC patients (
p
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| doi_str_mv | 10.1007/s10549-024-07422-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3075704845</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3075704845</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-ac21b2c0b5f30f5725a0edc37d8f9f32341ed4eaa3b9eab3bfac6feb583ee6813</originalsourceid><addsrcrecordid>eNp9kcFOHSEUhknTRq_WF-iiIemmG_QAwzDTXWPaanITN-2aMMxBx9wZpsBofac-ZLFXvdGFKxL4vh84PyEfOBxzAH2SOKiqZSAqBroSguk3ZMWVlkwLrt-SFfBas7qBep8cpHQNAK2Gdo_sy6atpRL1ivxdh-mSZYwjDUt2YUQaPB2mG5uGG6TzEpGOg4thtvOw2dh4R7uINmXq7OQw0qLMNmJPb4d8tRPH4U_Ze2Haqd8R_eKy3TxP-0ItHW12V8WNmGNIM7p8T6e89HfvyTtvNwmPHtZD8uv7t5-nZ2x98eP89OuaOaHqzKwTvBMOOuUleKWFsoC9k7pvfOulkBXHvkJrZdei7WTnras9dqqRiHXD5SH5vM2dY_i9YMpmHJLD8okJw5KMBK00VE2lCvrpBXodljiV1xnJueSN4FIWSmypMo6UInozx2EsIzEczH2XZtulKV2a_10aXaSPD9FLN2L_pDyWVwC5BVI5mi4x7u5-JfYfsfmviw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3113182133</pqid></control><display><type>article</type><title>Long-term outcome of invasive pure micropapillary breast cancer compared with invasive mixed micropapillary and invasive ductal breast cancer: a matched retrospective study</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Magnoni, Francesca ; Bianchi, Beatrice ; Pagan, Eleonora ; Corso, Giovanni ; Sala, Isabella ; Bagnardi, Vincenzo ; Claudia, Sangalli ; Brancaccio, Roberta ; Bottazzoli, Elisa ; Boato, Antony ; Munzone, Elisabetta ; Dellapasqua, Silvia ; Fusco, Nicola ; Viviana, Galimberti ; Veronesi, Paolo</creator><creatorcontrib>Magnoni, Francesca ; Bianchi, Beatrice ; Pagan, Eleonora ; Corso, Giovanni ; Sala, Isabella ; Bagnardi, Vincenzo ; Claudia, Sangalli ; Brancaccio, Roberta ; Bottazzoli, Elisa ; Boato, Antony ; Munzone, Elisabetta ; Dellapasqua, Silvia ; Fusco, Nicola ; Viviana, Galimberti ; Veronesi, Paolo</creatorcontrib><description>Purpose
Data on the prognostic impact of the micropapillary component in breast cancer are limited. The purpose of this study was to investigate the clinicopathological characteristics and long-term outcomes of pure and mixed invasive micropapillary breast cancer (IMPC) patients compared to invasive ductal cancer (IDC) patients.
Methods
This retrospective study analysed all IMPC and IDC patients treated at the European Institute of Oncology (IEO) between 1997 and 2019. The overall cohort of IMPC patients was divided in two groups, pure and mixed IMPC. Each patient with mixed or pure IMPC was matched with one patient with IDC, based on year of surgery, age, pT, pN, and molecular subtype.
Results
A total of 30,115 IDC, 120 pure IMPC and 150 mixed IMPC patients were considered eligible. Compared to IDC, pure and mixed IMPC patients presented a higher rate of locally advanced disease (pT2-T3, pN2-N3), vascular invasion, and Luminal B subtype. After matching, pure and mixed IMPC showed a significant higher rate of vascular invasion compared to IDC patients (
p
< 0.001). Invasive disease-free survival was better in IDC compared to pure IMPC patients (
p
= 0.11). Long-term overall survival was significantly worse in pure IMPC group compared to IDC group (
p
= 0.004), being instead similar between mixed IMPC vs matched IDC (
p
= 0.07).
Conclusion
These real-world data reported the worse prognosis of pure IMPC compared to IDC, highlighting the peculiar prognostic value of the micropapillary subtype itself in the decision-making process of IMPC management. An accurate pre-surgical diagnostic evaluation and a multidisciplinary approach are pivotal to best personalize its treatment.</description><identifier>ISSN: 0167-6806</identifier><identifier>ISSN: 1573-7217</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1007/s10549-024-07422-7</identifier><identifier>PMID: 38963526</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Aged ; Breast cancer ; Breast Neoplasms - mortality ; Breast Neoplasms - pathology ; Carcinoma, Ductal, Breast - mortality ; Carcinoma, Ductal, Breast - pathology ; Carcinoma, Papillary - mortality ; Carcinoma, Papillary - pathology ; Carcinoma, Papillary - surgery ; Decision making ; Disease-Free Survival ; Female ; Humans ; Invasiveness ; Medical prognosis ; Medical treatment ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Invasiveness ; Oncology ; Patients ; Prognosis ; Retrospective Studies ; Survival</subject><ispartof>Breast cancer research and treatment, 2024-11, Vol.208 (2), p.333-347</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-ac21b2c0b5f30f5725a0edc37d8f9f32341ed4eaa3b9eab3bfac6feb583ee6813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10549-024-07422-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10549-024-07422-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38963526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Magnoni, Francesca</creatorcontrib><creatorcontrib>Bianchi, Beatrice</creatorcontrib><creatorcontrib>Pagan, Eleonora</creatorcontrib><creatorcontrib>Corso, Giovanni</creatorcontrib><creatorcontrib>Sala, Isabella</creatorcontrib><creatorcontrib>Bagnardi, Vincenzo</creatorcontrib><creatorcontrib>Claudia, Sangalli</creatorcontrib><creatorcontrib>Brancaccio, Roberta</creatorcontrib><creatorcontrib>Bottazzoli, Elisa</creatorcontrib><creatorcontrib>Boato, Antony</creatorcontrib><creatorcontrib>Munzone, Elisabetta</creatorcontrib><creatorcontrib>Dellapasqua, Silvia</creatorcontrib><creatorcontrib>Fusco, Nicola</creatorcontrib><creatorcontrib>Viviana, Galimberti</creatorcontrib><creatorcontrib>Veronesi, Paolo</creatorcontrib><title>Long-term outcome of invasive pure micropapillary breast cancer compared with invasive mixed micropapillary and invasive ductal breast cancer: a matched retrospective study</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><addtitle>Breast Cancer Res Treat</addtitle><description>Purpose
Data on the prognostic impact of the micropapillary component in breast cancer are limited. The purpose of this study was to investigate the clinicopathological characteristics and long-term outcomes of pure and mixed invasive micropapillary breast cancer (IMPC) patients compared to invasive ductal cancer (IDC) patients.
Methods
This retrospective study analysed all IMPC and IDC patients treated at the European Institute of Oncology (IEO) between 1997 and 2019. The overall cohort of IMPC patients was divided in two groups, pure and mixed IMPC. Each patient with mixed or pure IMPC was matched with one patient with IDC, based on year of surgery, age, pT, pN, and molecular subtype.
Results
A total of 30,115 IDC, 120 pure IMPC and 150 mixed IMPC patients were considered eligible. Compared to IDC, pure and mixed IMPC patients presented a higher rate of locally advanced disease (pT2-T3, pN2-N3), vascular invasion, and Luminal B subtype. After matching, pure and mixed IMPC showed a significant higher rate of vascular invasion compared to IDC patients (
p
< 0.001). Invasive disease-free survival was better in IDC compared to pure IMPC patients (
p
= 0.11). Long-term overall survival was significantly worse in pure IMPC group compared to IDC group (
p
= 0.004), being instead similar between mixed IMPC vs matched IDC (
p
= 0.07).
Conclusion
These real-world data reported the worse prognosis of pure IMPC compared to IDC, highlighting the peculiar prognostic value of the micropapillary subtype itself in the decision-making process of IMPC management. An accurate pre-surgical diagnostic evaluation and a multidisciplinary approach are pivotal to best personalize its treatment.</description><subject>Adult</subject><subject>Aged</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma, Ductal, Breast - mortality</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Carcinoma, Papillary - mortality</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Carcinoma, Papillary - surgery</subject><subject>Decision making</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Invasiveness</subject><subject>Medical prognosis</subject><subject>Medical treatment</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Oncology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Survival</subject><issn>0167-6806</issn><issn>1573-7217</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFOHSEUhknTRq_WF-iiIemmG_QAwzDTXWPaanITN-2aMMxBx9wZpsBofac-ZLFXvdGFKxL4vh84PyEfOBxzAH2SOKiqZSAqBroSguk3ZMWVlkwLrt-SFfBas7qBep8cpHQNAK2Gdo_sy6atpRL1ivxdh-mSZYwjDUt2YUQaPB2mG5uGG6TzEpGOg4thtvOw2dh4R7uINmXq7OQw0qLMNmJPb4d8tRPH4U_Ze2Haqd8R_eKy3TxP-0ItHW12V8WNmGNIM7p8T6e89HfvyTtvNwmPHtZD8uv7t5-nZ2x98eP89OuaOaHqzKwTvBMOOuUleKWFsoC9k7pvfOulkBXHvkJrZdei7WTnras9dqqRiHXD5SH5vM2dY_i9YMpmHJLD8okJw5KMBK00VE2lCvrpBXodljiV1xnJueSN4FIWSmypMo6UInozx2EsIzEczH2XZtulKV2a_10aXaSPD9FLN2L_pDyWVwC5BVI5mi4x7u5-JfYfsfmviw</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>Magnoni, Francesca</creator><creator>Bianchi, Beatrice</creator><creator>Pagan, Eleonora</creator><creator>Corso, Giovanni</creator><creator>Sala, Isabella</creator><creator>Bagnardi, Vincenzo</creator><creator>Claudia, Sangalli</creator><creator>Brancaccio, Roberta</creator><creator>Bottazzoli, Elisa</creator><creator>Boato, Antony</creator><creator>Munzone, Elisabetta</creator><creator>Dellapasqua, Silvia</creator><creator>Fusco, Nicola</creator><creator>Viviana, Galimberti</creator><creator>Veronesi, Paolo</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20241101</creationdate><title>Long-term outcome of invasive pure micropapillary breast cancer compared with invasive mixed micropapillary and invasive ductal breast cancer: a matched retrospective study</title><author>Magnoni, Francesca ; Bianchi, Beatrice ; Pagan, Eleonora ; Corso, Giovanni ; Sala, Isabella ; Bagnardi, Vincenzo ; Claudia, Sangalli ; Brancaccio, Roberta ; Bottazzoli, Elisa ; Boato, Antony ; Munzone, Elisabetta ; Dellapasqua, Silvia ; Fusco, Nicola ; Viviana, Galimberti ; Veronesi, Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-ac21b2c0b5f30f5725a0edc37d8f9f32341ed4eaa3b9eab3bfac6feb583ee6813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - mortality</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinoma, Ductal, Breast - mortality</topic><topic>Carcinoma, Ductal, Breast - pathology</topic><topic>Carcinoma, Papillary - mortality</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Carcinoma, Papillary - surgery</topic><topic>Decision making</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Invasiveness</topic><topic>Medical prognosis</topic><topic>Medical treatment</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Oncology</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Magnoni, Francesca</creatorcontrib><creatorcontrib>Bianchi, Beatrice</creatorcontrib><creatorcontrib>Pagan, Eleonora</creatorcontrib><creatorcontrib>Corso, Giovanni</creatorcontrib><creatorcontrib>Sala, Isabella</creatorcontrib><creatorcontrib>Bagnardi, Vincenzo</creatorcontrib><creatorcontrib>Claudia, Sangalli</creatorcontrib><creatorcontrib>Brancaccio, Roberta</creatorcontrib><creatorcontrib>Bottazzoli, Elisa</creatorcontrib><creatorcontrib>Boato, Antony</creatorcontrib><creatorcontrib>Munzone, Elisabetta</creatorcontrib><creatorcontrib>Dellapasqua, Silvia</creatorcontrib><creatorcontrib>Fusco, Nicola</creatorcontrib><creatorcontrib>Viviana, Galimberti</creatorcontrib><creatorcontrib>Veronesi, Paolo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Breast cancer research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Magnoni, Francesca</au><au>Bianchi, Beatrice</au><au>Pagan, Eleonora</au><au>Corso, Giovanni</au><au>Sala, Isabella</au><au>Bagnardi, Vincenzo</au><au>Claudia, Sangalli</au><au>Brancaccio, Roberta</au><au>Bottazzoli, Elisa</au><au>Boato, Antony</au><au>Munzone, Elisabetta</au><au>Dellapasqua, Silvia</au><au>Fusco, Nicola</au><au>Viviana, Galimberti</au><au>Veronesi, Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term outcome of invasive pure micropapillary breast cancer compared with invasive mixed micropapillary and invasive ductal breast cancer: a matched retrospective study</atitle><jtitle>Breast cancer research and treatment</jtitle><stitle>Breast Cancer Res Treat</stitle><addtitle>Breast Cancer Res Treat</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>208</volume><issue>2</issue><spage>333</spage><epage>347</epage><pages>333-347</pages><issn>0167-6806</issn><issn>1573-7217</issn><eissn>1573-7217</eissn><abstract>Purpose
Data on the prognostic impact of the micropapillary component in breast cancer are limited. The purpose of this study was to investigate the clinicopathological characteristics and long-term outcomes of pure and mixed invasive micropapillary breast cancer (IMPC) patients compared to invasive ductal cancer (IDC) patients.
Methods
This retrospective study analysed all IMPC and IDC patients treated at the European Institute of Oncology (IEO) between 1997 and 2019. The overall cohort of IMPC patients was divided in two groups, pure and mixed IMPC. Each patient with mixed or pure IMPC was matched with one patient with IDC, based on year of surgery, age, pT, pN, and molecular subtype.
Results
A total of 30,115 IDC, 120 pure IMPC and 150 mixed IMPC patients were considered eligible. Compared to IDC, pure and mixed IMPC patients presented a higher rate of locally advanced disease (pT2-T3, pN2-N3), vascular invasion, and Luminal B subtype. After matching, pure and mixed IMPC showed a significant higher rate of vascular invasion compared to IDC patients (
p
< 0.001). Invasive disease-free survival was better in IDC compared to pure IMPC patients (
p
= 0.11). Long-term overall survival was significantly worse in pure IMPC group compared to IDC group (
p
= 0.004), being instead similar between mixed IMPC vs matched IDC (
p
= 0.07).
Conclusion
These real-world data reported the worse prognosis of pure IMPC compared to IDC, highlighting the peculiar prognostic value of the micropapillary subtype itself in the decision-making process of IMPC management. An accurate pre-surgical diagnostic evaluation and a multidisciplinary approach are pivotal to best personalize its treatment.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38963526</pmid><doi>10.1007/s10549-024-07422-7</doi><tpages>15</tpages></addata></record> |
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| subjects | Adult Aged Breast cancer Breast Neoplasms - mortality Breast Neoplasms - pathology Carcinoma, Ductal, Breast - mortality Carcinoma, Ductal, Breast - pathology Carcinoma, Papillary - mortality Carcinoma, Papillary - pathology Carcinoma, Papillary - surgery Decision making Disease-Free Survival Female Humans Invasiveness Medical prognosis Medical treatment Medicine Medicine & Public Health Middle Aged Neoplasm Invasiveness Oncology Patients Prognosis Retrospective Studies Survival |
| title | Long-term outcome of invasive pure micropapillary breast cancer compared with invasive mixed micropapillary and invasive ductal breast cancer: a matched retrospective study |
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