Impaired myoblast differentiation and muscle IGF‐1 receptor signaling pathway activation after N‐glycosylation inhibition

The role of N‐glycosylation in the myogenic process remains poorly understood. Here, we evaluated the impact of N‐glycosylation inhibition by Tunicamycin (TUN) or by phosphomannomutase 2 (PMM2) gene knockdown, which encodes an enzyme essential for catalyzing an early step of the N‐glycosylation path...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The FASEB journal 2024-07, Vol.38 (13), p.e23797-n/a
Hauptverfasser:	Annibalini, Giosuè, Di Patria, Laura, Valli, Giacomo, Bocconcelli, Matteo, Saltarelli, Roberta, Ferri, Lorenzo, Barberi, Laura, Fanelli, Fabiana, Morrone, Amelia, Barone, Rita, Guerrini, Renzo, Musarò, Antonio, Stocchi, Vilberto, Barbieri, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cell Line congenital disorders of glycosylation Endoplasmic Reticulum Chaperone BiP - metabolism Endoplasmic Reticulum Stress Glycosylation IGF1R signaling pathway Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Mice Mice, Transgenic muscle atrophy Muscle Development - physiology Muscle, Skeletal - metabolism myoblast differentiation Myoblasts - metabolism PMM2 Receptor, IGF Type 1 - genetics Receptor, IGF Type 1 - metabolism Signal Transduction Tunicamycin - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!