The role of TNF‐α as a potential marker for acute cutaneous lupus erythematosus in patients with systemic lupus erythematosus
Acute cutaneous lupus erythematosus (ACLE) is closely associated with systemic symptoms in systemic lupus erythematosus (SLE). This study aimed to identify potential biomarkers for ACLE and explore their association with SLE to enable early prediction of ACLE and identify potential treatment targets...
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| Veröffentlicht in: | Journal of dermatology 2024-11, Vol.51 (11), p.1481-1491 |
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| creator | Jinshan, Zhan Yong, Qu Fangqi, Chen Juanmei, Cao Min, Li Changzheng, Huang |
| description | Acute cutaneous lupus erythematosus (ACLE) is closely associated with systemic symptoms in systemic lupus erythematosus (SLE). This study aimed to identify potential biomarkers for ACLE and explore their association with SLE to enable early prediction of ACLE and identify potential treatment targets for the future. In total, 185 SLE‐diagnosed patients were enrolled and categorized into two groups: those with ACLE and those without cutaneous involvement. After conducting logistic regression analysis of the differentiating factors, we concluded that tumor necrosis factor‐alpha (TNF‐α) is an independent risk factor for ACLE. Analysis of the receiver operating characteristic revealed an area under the curve of 0.716 for TNF‐α. Additionally, both TNF‐α and ACLE are positively correlated with disease activity. TNF‐α shows promise as a biomarker for ACLE, and in SLE patients, ACLE may serve as a clear indicator of moderate‐to‐severe disease activity. |
| doi_str_mv | 10.1111/1346-8138.17355 |
| format | Article |
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This study aimed to identify potential biomarkers for ACLE and explore their association with SLE to enable early prediction of ACLE and identify potential treatment targets for the future. In total, 185 SLE‐diagnosed patients were enrolled and categorized into two groups: those with ACLE and those without cutaneous involvement. After conducting logistic regression analysis of the differentiating factors, we concluded that tumor necrosis factor‐alpha (TNF‐α) is an independent risk factor for ACLE. Analysis of the receiver operating characteristic revealed an area under the curve of 0.716 for TNF‐α. Additionally, both TNF‐α and ACLE are positively correlated with disease activity. TNF‐α shows promise as a biomarker for ACLE, and in SLE patients, ACLE may serve as a clear indicator of moderate‐to‐severe disease activity.</description><identifier>ISSN: 0385-2407</identifier><identifier>ISSN: 1346-8138</identifier><identifier>EISSN: 1346-8138</identifier><identifier>DOI: 10.1111/1346-8138.17355</identifier><identifier>PMID: 38963308</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>acute cutaneous lupus erythematosus ; Acute Disease ; Adult ; biomarker ; Biomarkers ; Biomarkers - blood ; Cutaneous Lupus Erythematosus ; disease activity ; Female ; Humans ; Lupus Erythematosus, Cutaneous - blood ; Lupus Erythematosus, Cutaneous - diagnosis ; Lupus Erythematosus, Cutaneous - immunology ; Lupus Erythematosus, Systemic - blood ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - diagnosis ; Lupus Erythematosus, Systemic - immunology ; Male ; Medical treatment ; Middle Aged ; Risk Factors ; ROC Curve ; Severity of Illness Index ; Systemic lupus erythematosus ; Tumor necrosis factor ; tumor necrosis factor alpha ; Tumor Necrosis Factor-alpha - blood ; Young Adult</subject><ispartof>Journal of dermatology, 2024-11, Vol.51 (11), p.1481-1491</ispartof><rights>2024 Japanese Dermatological Association.</rights><rights>Copyright © 2024 Japanese Dermatological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3255-fb26f0bf12224bdb57f78b22234bc2ef44dd1b5589ee2345e4dce432753040733</cites><orcidid>0000-0003-1531-1269 ; 0000-0003-1208-9383</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1346-8138.17355$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1346-8138.17355$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38963308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jinshan, Zhan</creatorcontrib><creatorcontrib>Yong, Qu</creatorcontrib><creatorcontrib>Fangqi, Chen</creatorcontrib><creatorcontrib>Juanmei, Cao</creatorcontrib><creatorcontrib>Min, Li</creatorcontrib><creatorcontrib>Changzheng, Huang</creatorcontrib><title>The role of TNF‐α as a potential marker for acute cutaneous lupus erythematosus in patients with systemic lupus erythematosus</title><title>Journal of dermatology</title><addtitle>J Dermatol</addtitle><description>Acute cutaneous lupus erythematosus (ACLE) is closely associated with systemic symptoms in systemic lupus erythematosus (SLE). This study aimed to identify potential biomarkers for ACLE and explore their association with SLE to enable early prediction of ACLE and identify potential treatment targets for the future. In total, 185 SLE‐diagnosed patients were enrolled and categorized into two groups: those with ACLE and those without cutaneous involvement. After conducting logistic regression analysis of the differentiating factors, we concluded that tumor necrosis factor‐alpha (TNF‐α) is an independent risk factor for ACLE. Analysis of the receiver operating characteristic revealed an area under the curve of 0.716 for TNF‐α. Additionally, both TNF‐α and ACLE are positively correlated with disease activity. TNF‐α shows promise as a biomarker for ACLE, and in SLE patients, ACLE may serve as a clear indicator of moderate‐to‐severe disease activity.</description><subject>acute cutaneous lupus erythematosus</subject><subject>Acute Disease</subject><subject>Adult</subject><subject>biomarker</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Cutaneous Lupus Erythematosus</subject><subject>disease activity</subject><subject>Female</subject><subject>Humans</subject><subject>Lupus Erythematosus, Cutaneous - blood</subject><subject>Lupus Erythematosus, Cutaneous - diagnosis</subject><subject>Lupus Erythematosus, Cutaneous - immunology</subject><subject>Lupus Erythematosus, Systemic - blood</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lupus Erythematosus, Systemic - diagnosis</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Male</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Severity of Illness Index</subject><subject>Systemic lupus erythematosus</subject><subject>Tumor necrosis factor</subject><subject>tumor necrosis factor alpha</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Young Adult</subject><issn>0385-2407</issn><issn>1346-8138</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9O3DAQxq2qVVloz71VlnrhErA98dp7rPhfoXLZni0nGWtDk3WwHaG98Qi8Ci_Sh-iT4CWUA6rEHGY0o998sucj5AtnBzzHIYdyXmgO-oArkPIdmb1M3pMZAy0LUTK1Q3ZjvGZMLCRnH8kO6MUcgOkZuVuukAbfIfWOLn-e_r27__NAbaSWDj7hOrW2o70NvzFQ5wO19ZiQ5mTX6MdIu3HIGcMmrbC3ycfctWs62NTm5Uhv27SicRMT9m39P_oT-eBsF_Hzc90jv05PlkfnxeXV2cXR98uiBiFl4Soxd6xyXAhRVk0llVO6yg2UVS3QlWXT8EpKvUDMM4llU2MJQklg-QAAe2R_0h2CvxkxJtO3scaumz5igCmpGCihM_rtFXrtx7DOrzPABfC5XGiVqcOJqoOPMaAzQ2jzpTaGM7M1x2ytMFsrzJM5eePrs-5Y9di88P_cyICcgNu2w81beubH8ckk_AhZrJvC</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Jinshan, Zhan</creator><creator>Yong, Qu</creator><creator>Fangqi, Chen</creator><creator>Juanmei, Cao</creator><creator>Min, Li</creator><creator>Changzheng, Huang</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1531-1269</orcidid><orcidid>https://orcid.org/0000-0003-1208-9383</orcidid></search><sort><creationdate>202411</creationdate><title>The role of TNF‐α as a potential marker for acute cutaneous lupus erythematosus in patients with systemic lupus erythematosus</title><author>Jinshan, Zhan ; Yong, Qu ; Fangqi, Chen ; Juanmei, Cao ; Min, Li ; Changzheng, Huang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3255-fb26f0bf12224bdb57f78b22234bc2ef44dd1b5589ee2345e4dce432753040733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>acute cutaneous lupus erythematosus</topic><topic>Acute Disease</topic><topic>Adult</topic><topic>biomarker</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Cutaneous Lupus Erythematosus</topic><topic>disease activity</topic><topic>Female</topic><topic>Humans</topic><topic>Lupus Erythematosus, Cutaneous - blood</topic><topic>Lupus Erythematosus, Cutaneous - diagnosis</topic><topic>Lupus Erythematosus, Cutaneous - immunology</topic><topic>Lupus Erythematosus, Systemic - blood</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Lupus Erythematosus, Systemic - diagnosis</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Male</topic><topic>Medical treatment</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Severity of Illness Index</topic><topic>Systemic lupus erythematosus</topic><topic>Tumor necrosis factor</topic><topic>tumor necrosis factor alpha</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jinshan, Zhan</creatorcontrib><creatorcontrib>Yong, Qu</creatorcontrib><creatorcontrib>Fangqi, Chen</creatorcontrib><creatorcontrib>Juanmei, Cao</creatorcontrib><creatorcontrib>Min, Li</creatorcontrib><creatorcontrib>Changzheng, Huang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jinshan, Zhan</au><au>Yong, Qu</au><au>Fangqi, Chen</au><au>Juanmei, Cao</au><au>Min, Li</au><au>Changzheng, Huang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of TNF‐α as a potential marker for acute cutaneous lupus erythematosus in patients with systemic lupus erythematosus</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2024-11</date><risdate>2024</risdate><volume>51</volume><issue>11</issue><spage>1481</spage><epage>1491</epage><pages>1481-1491</pages><issn>0385-2407</issn><issn>1346-8138</issn><eissn>1346-8138</eissn><abstract>Acute cutaneous lupus erythematosus (ACLE) is closely associated with systemic symptoms in systemic lupus erythematosus (SLE). This study aimed to identify potential biomarkers for ACLE and explore their association with SLE to enable early prediction of ACLE and identify potential treatment targets for the future. In total, 185 SLE‐diagnosed patients were enrolled and categorized into two groups: those with ACLE and those without cutaneous involvement. After conducting logistic regression analysis of the differentiating factors, we concluded that tumor necrosis factor‐alpha (TNF‐α) is an independent risk factor for ACLE. Analysis of the receiver operating characteristic revealed an area under the curve of 0.716 for TNF‐α. Additionally, both TNF‐α and ACLE are positively correlated with disease activity. 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| subjects | acute cutaneous lupus erythematosus Acute Disease Adult biomarker Biomarkers Biomarkers - blood Cutaneous Lupus Erythematosus disease activity Female Humans Lupus Erythematosus, Cutaneous - blood Lupus Erythematosus, Cutaneous - diagnosis Lupus Erythematosus, Cutaneous - immunology Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - diagnosis Lupus Erythematosus, Systemic - immunology Male Medical treatment Middle Aged Risk Factors ROC Curve Severity of Illness Index Systemic lupus erythematosus Tumor necrosis factor tumor necrosis factor alpha Tumor Necrosis Factor-alpha - blood Young Adult |
| title | The role of TNF‐α as a potential marker for acute cutaneous lupus erythematosus in patients with systemic lupus erythematosus |
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