PIEZO1 activation may serve as an early tissue biomarker for the prediction of irradiation-induced salivary gland dysfunction

Irradiation (IR)-induced xerostomia is the most common side effect of radiation therapy in patients with head and neck cancer (HNC). Xerostomia diagnosis is mainly based on the patient's medical history and symptoms. Currently, no direct biomarkers are available for the early prediction of IR-i...

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Veröffentlicht in:	Biochemical and biophysical research communications 2024-10, Vol.727, p.150291, Article 150291
Hauptverfasser:	Nguyen, Lan Thi Phuong, Kim, Yunhye, Hur, Sung Sik, Byeon, Hyung Kwon, Ban, Myung Jin, Shim, Jae-Won, Park, Jae Hong, Hwang, Yongsung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - metabolism Humans Ion Channels - genetics Ion Channels - metabolism Irradiation Male Mice Mice, Inbred C57BL PIEZO1 Salivary gland Salivary Glands - metabolism Salivary Glands - radiation effects Tissue biomarker Up-Regulation - radiation effects Xerostomia Xerostomia - etiology Xerostomia - metabolism
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