Identification and validation of sialyltransferase ST3Gal5 in bladder cancer through bioinformatics and experimental analysis

•ST3Gal5 was downregulated in BLCA patients and cells through various bioinformatics and experimental validation.•ST3Gal5 served as an independent prognostic factor in BLCA.•Aberrant ST3Gal5 expression led to immune dysregulation in BLCA patients.•Overexpression of ST3Gal5 suppressed the occurrence...

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Veröffentlicht in:	International immunopharmacology 2024-09, Vol.138, p.112569, Article 112569
Hauptverfasser:	Jian, Yuli, Chen, Qiwei, Al-danakh, Abdullah, Xu, Zhongyang, Xu, Chunyan, Sun, Xiaoxin, Yu, Xiao, Yang, Deyong, Wang, Shujing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Galactoside alpha-2,3-Sialyltransferase Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Bladder cancer Cell Line, Tumor Cell Movement Cell Proliferation Computational Biology - methods Female Gene Expression Regulation, Neoplastic Humans Immunotherapy Male Mice Mice, Nude Prognosis Prognostic biomarker Sialyltransferases - genetics Sialyltransferases - metabolism ST3Gal5 Tumorigenesis Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - immunology Urinary Bladder Neoplasms - mortality
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