Clinical characteristics and management outcome of acute infectious endophthalmitis
Purpose This study aimed to investigate the demographics, clinical characteristics, and management outcomes of patients with acute infectious endophthalmitis (AIE). Methods This retrospective chart review was conducted on all patients admitted with the clinical diagnosis of infectious endophthalmiti...
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| Veröffentlicht in: | International ophthalmology 2024-07, Vol.44 (1), p.308, Article 308 |
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| creator | Abrishami, Mojtaba Abrishami, Majid Hatami, Nahid Shoeibi, Nasser Hosseini, Seyedeh Maryam Ansari Astaneh, Mohammad Reza Bakhtiari, Elham Motamed Shariati, Mehrdad |
| description | Purpose
This study aimed to investigate the demographics, clinical characteristics, and management outcomes of patients with acute infectious endophthalmitis (AIE).
Methods
This retrospective chart review was conducted on all patients admitted with the clinical diagnosis of infectious endophthalmitis from 2017 to 2022. Demographic data, patients’ clinical characteristics, the type of acute infectious endophthalmitis (post-operative, post-traumatic, bleb-associated, and endogenous endophthalmitis), the type of surgical procedure in the post-operative cases, the microbiologic analysis results of vitreous samples, therapeutic measures, and visual outcomes of patients were recorded.
Results
In this study, 182 participants, including 122 male (67%) and 60 (33%) female, were involved. The mean age of patients was 54.56 ± 21 years, with a range of 1–88 years old. The most prevalent type of AIE was post-operative (59.9%), followed by endogenous (19.2%), post-traumatic (17%), and bleb-associated (3.8%). The most common type of intraocular surgery in the post-operative subgroups of AIE patients was phacoemulsification (57.8%). The median (interquartile range) of the primary and final BCVA of patients was 1.5 (1.35, 1.85) and 0.65 (0.35, 1.35), respectively. Vitreous haziness grade (OR, 2.89; 95% CI, 1.11–5.74;
p
= 0.009) and the primary VA (OR, 60.34; 95% CI, 2.87–126.8;
p
= 0.008) revealed statistical significance for final vision loss.
Conclusion
AIE is a devastating condition with poor visual outcomes, which presents with acute inflammatory signs and symptoms regardless of its type. However, prompt and appropriate treatment leads to visual recovery to a functional level in many patients. |
| doi_str_mv | 10.1007/s10792-024-03239-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3075377968</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3075377968</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-17882596381290d31fd7ffbcbb5979433afdcf81ba3b311b1b80012e2e11dae03</originalsourceid><addsrcrecordid>eNp9kMtOAyEUhonR2Hp5ARdmEjduRrl0CixN4y0xcaGuCcMcWpoZpgKT1LcXbb3EhStI-M7Pfz6ETgi-IBjzy0gwl7TEdFJiRpks1ztoTCrOSjplePfXfYQOYlxijCWX0300YkJWggs5Rk-z1nlndFuYhQ7aJAguJmdioX1TdNrrOXTgU9EPyfQdFL0ttBkSFM5bMMn1QyzAN_1qkRa67Vxy8QjtWd1GON6eh-jl5vp5dlc-PN7ez64eSkOraSoJF4JWcsoEoRI3jNiGW1ubuq5yzQlj2jbGClJrVjNCalILjAkFCoQ0GjA7ROeb3FXoXweISXUuGmhb7SHXUgzzivG8scjo2R902Q_B53af1GQiBWeZohvKhD7GAFatgut0eFMEqw_laqNcZeXqU7la56HTbfRQd9B8j3w5zgDbADE_-TmEn7__iX0H-CGNRA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3075449873</pqid></control><display><type>article</type><title>Clinical characteristics and management outcome of acute infectious endophthalmitis</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Abrishami, Mojtaba ; Abrishami, Majid ; Hatami, Nahid ; Shoeibi, Nasser ; Hosseini, Seyedeh Maryam ; Ansari Astaneh, Mohammad Reza ; Bakhtiari, Elham ; Motamed Shariati, Mehrdad</creator><creatorcontrib>Abrishami, Mojtaba ; Abrishami, Majid ; Hatami, Nahid ; Shoeibi, Nasser ; Hosseini, Seyedeh Maryam ; Ansari Astaneh, Mohammad Reza ; Bakhtiari, Elham ; Motamed Shariati, Mehrdad</creatorcontrib><description>Purpose
This study aimed to investigate the demographics, clinical characteristics, and management outcomes of patients with acute infectious endophthalmitis (AIE).
Methods
This retrospective chart review was conducted on all patients admitted with the clinical diagnosis of infectious endophthalmitis from 2017 to 2022. Demographic data, patients’ clinical characteristics, the type of acute infectious endophthalmitis (post-operative, post-traumatic, bleb-associated, and endogenous endophthalmitis), the type of surgical procedure in the post-operative cases, the microbiologic analysis results of vitreous samples, therapeutic measures, and visual outcomes of patients were recorded.
Results
In this study, 182 participants, including 122 male (67%) and 60 (33%) female, were involved. The mean age of patients was 54.56 ± 21 years, with a range of 1–88 years old. The most prevalent type of AIE was post-operative (59.9%), followed by endogenous (19.2%), post-traumatic (17%), and bleb-associated (3.8%). The most common type of intraocular surgery in the post-operative subgroups of AIE patients was phacoemulsification (57.8%). The median (interquartile range) of the primary and final BCVA of patients was 1.5 (1.35, 1.85) and 0.65 (0.35, 1.35), respectively. Vitreous haziness grade (OR, 2.89; 95% CI, 1.11–5.74;
p
= 0.009) and the primary VA (OR, 60.34; 95% CI, 2.87–126.8;
p
= 0.008) revealed statistical significance for final vision loss.
Conclusion
AIE is a devastating condition with poor visual outcomes, which presents with acute inflammatory signs and symptoms regardless of its type. However, prompt and appropriate treatment leads to visual recovery to a functional level in many patients.</description><identifier>ISSN: 1573-2630</identifier><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-024-03239-x</identifier><identifier>PMID: 38958789</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Acute Disease ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Child ; Child, Preschool ; Demographics ; Demography ; Endophthalmitis ; Endophthalmitis - diagnosis ; Endophthalmitis - epidemiology ; Endophthalmitis - microbiology ; Endophthalmitis - therapy ; Eye Infections, Bacterial - diagnosis ; Eye Infections, Bacterial - epidemiology ; Eye Infections, Bacterial - microbiology ; Eye Infections, Bacterial - therapy ; Female ; Glaucoma ; Humans ; Infant ; Inflammation ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Ophthalmology ; Original Paper ; Patients ; Recovery of function ; Retrospective Studies ; Signs and symptoms ; Subgroups ; Surgery ; Surgical outcomes ; Ultrasonic imaging ; Visual Acuity ; Vitrectomy - methods ; Vitreous Body - microbiology ; Vitreous Body - pathology ; Young Adult</subject><ispartof>International ophthalmology, 2024-07, Vol.44 (1), p.308, Article 308</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Nature B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-17882596381290d31fd7ffbcbb5979433afdcf81ba3b311b1b80012e2e11dae03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10792-024-03239-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10792-024-03239-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38958789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abrishami, Mojtaba</creatorcontrib><creatorcontrib>Abrishami, Majid</creatorcontrib><creatorcontrib>Hatami, Nahid</creatorcontrib><creatorcontrib>Shoeibi, Nasser</creatorcontrib><creatorcontrib>Hosseini, Seyedeh Maryam</creatorcontrib><creatorcontrib>Ansari Astaneh, Mohammad Reza</creatorcontrib><creatorcontrib>Bakhtiari, Elham</creatorcontrib><creatorcontrib>Motamed Shariati, Mehrdad</creatorcontrib><title>Clinical characteristics and management outcome of acute infectious endophthalmitis</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose
This study aimed to investigate the demographics, clinical characteristics, and management outcomes of patients with acute infectious endophthalmitis (AIE).
Methods
This retrospective chart review was conducted on all patients admitted with the clinical diagnosis of infectious endophthalmitis from 2017 to 2022. Demographic data, patients’ clinical characteristics, the type of acute infectious endophthalmitis (post-operative, post-traumatic, bleb-associated, and endogenous endophthalmitis), the type of surgical procedure in the post-operative cases, the microbiologic analysis results of vitreous samples, therapeutic measures, and visual outcomes of patients were recorded.
Results
In this study, 182 participants, including 122 male (67%) and 60 (33%) female, were involved. The mean age of patients was 54.56 ± 21 years, with a range of 1–88 years old. The most prevalent type of AIE was post-operative (59.9%), followed by endogenous (19.2%), post-traumatic (17%), and bleb-associated (3.8%). The most common type of intraocular surgery in the post-operative subgroups of AIE patients was phacoemulsification (57.8%). The median (interquartile range) of the primary and final BCVA of patients was 1.5 (1.35, 1.85) and 0.65 (0.35, 1.35), respectively. Vitreous haziness grade (OR, 2.89; 95% CI, 1.11–5.74;
p
= 0.009) and the primary VA (OR, 60.34; 95% CI, 2.87–126.8;
p
= 0.008) revealed statistical significance for final vision loss.
Conclusion
AIE is a devastating condition with poor visual outcomes, which presents with acute inflammatory signs and symptoms regardless of its type. However, prompt and appropriate treatment leads to visual recovery to a functional level in many patients.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Demographics</subject><subject>Demography</subject><subject>Endophthalmitis</subject><subject>Endophthalmitis - diagnosis</subject><subject>Endophthalmitis - epidemiology</subject><subject>Endophthalmitis - microbiology</subject><subject>Endophthalmitis - therapy</subject><subject>Eye Infections, Bacterial - diagnosis</subject><subject>Eye Infections, Bacterial - epidemiology</subject><subject>Eye Infections, Bacterial - microbiology</subject><subject>Eye Infections, Bacterial - therapy</subject><subject>Female</subject><subject>Glaucoma</subject><subject>Humans</subject><subject>Infant</subject><subject>Inflammation</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Original Paper</subject><subject>Patients</subject><subject>Recovery of function</subject><subject>Retrospective Studies</subject><subject>Signs and symptoms</subject><subject>Subgroups</subject><subject>Surgery</subject><subject>Surgical outcomes</subject><subject>Ultrasonic imaging</subject><subject>Visual Acuity</subject><subject>Vitrectomy - methods</subject><subject>Vitreous Body - microbiology</subject><subject>Vitreous Body - pathology</subject><subject>Young Adult</subject><issn>1573-2630</issn><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOAyEUhonR2Hp5ARdmEjduRrl0CixN4y0xcaGuCcMcWpoZpgKT1LcXbb3EhStI-M7Pfz6ETgi-IBjzy0gwl7TEdFJiRpks1ztoTCrOSjplePfXfYQOYlxijCWX0300YkJWggs5Rk-z1nlndFuYhQ7aJAguJmdioX1TdNrrOXTgU9EPyfQdFL0ttBkSFM5bMMn1QyzAN_1qkRa67Vxy8QjtWd1GON6eh-jl5vp5dlc-PN7ez64eSkOraSoJF4JWcsoEoRI3jNiGW1ubuq5yzQlj2jbGClJrVjNCalILjAkFCoQ0GjA7ROeb3FXoXweISXUuGmhb7SHXUgzzivG8scjo2R902Q_B53af1GQiBWeZohvKhD7GAFatgut0eFMEqw_laqNcZeXqU7la56HTbfRQd9B8j3w5zgDbADE_-TmEn7__iX0H-CGNRA</recordid><startdate>20240703</startdate><enddate>20240703</enddate><creator>Abrishami, Mojtaba</creator><creator>Abrishami, Majid</creator><creator>Hatami, Nahid</creator><creator>Shoeibi, Nasser</creator><creator>Hosseini, Seyedeh Maryam</creator><creator>Ansari Astaneh, Mohammad Reza</creator><creator>Bakhtiari, Elham</creator><creator>Motamed Shariati, Mehrdad</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20240703</creationdate><title>Clinical characteristics and management outcome of acute infectious endophthalmitis</title><author>Abrishami, Mojtaba ; 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This study aimed to investigate the demographics, clinical characteristics, and management outcomes of patients with acute infectious endophthalmitis (AIE).
Methods
This retrospective chart review was conducted on all patients admitted with the clinical diagnosis of infectious endophthalmitis from 2017 to 2022. Demographic data, patients’ clinical characteristics, the type of acute infectious endophthalmitis (post-operative, post-traumatic, bleb-associated, and endogenous endophthalmitis), the type of surgical procedure in the post-operative cases, the microbiologic analysis results of vitreous samples, therapeutic measures, and visual outcomes of patients were recorded.
Results
In this study, 182 participants, including 122 male (67%) and 60 (33%) female, were involved. The mean age of patients was 54.56 ± 21 years, with a range of 1–88 years old. The most prevalent type of AIE was post-operative (59.9%), followed by endogenous (19.2%), post-traumatic (17%), and bleb-associated (3.8%). The most common type of intraocular surgery in the post-operative subgroups of AIE patients was phacoemulsification (57.8%). The median (interquartile range) of the primary and final BCVA of patients was 1.5 (1.35, 1.85) and 0.65 (0.35, 1.35), respectively. Vitreous haziness grade (OR, 2.89; 95% CI, 1.11–5.74;
p
= 0.009) and the primary VA (OR, 60.34; 95% CI, 2.87–126.8;
p
= 0.008) revealed statistical significance for final vision loss.
Conclusion
AIE is a devastating condition with poor visual outcomes, which presents with acute inflammatory signs and symptoms regardless of its type. However, prompt and appropriate treatment leads to visual recovery to a functional level in many patients.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>38958789</pmid><doi>10.1007/s10792-024-03239-x</doi></addata></record> |
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| subjects | Acute Disease Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents - therapeutic use Antibiotics Child Child, Preschool Demographics Demography Endophthalmitis Endophthalmitis - diagnosis Endophthalmitis - epidemiology Endophthalmitis - microbiology Endophthalmitis - therapy Eye Infections, Bacterial - diagnosis Eye Infections, Bacterial - epidemiology Eye Infections, Bacterial - microbiology Eye Infections, Bacterial - therapy Female Glaucoma Humans Infant Inflammation Male Medicine Medicine & Public Health Middle Aged Ophthalmology Original Paper Patients Recovery of function Retrospective Studies Signs and symptoms Subgroups Surgery Surgical outcomes Ultrasonic imaging Visual Acuity Vitrectomy - methods Vitreous Body - microbiology Vitreous Body - pathology Young Adult |
| title | Clinical characteristics and management outcome of acute infectious endophthalmitis |
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