Glutathione-mediated redox regulation in Cryptococcus neoformans impacts virulence

The fungal pathogen Cryptococcus neoformans is well adapted to its host environment. It has several defence mechanisms to evade oxidative and nitrosative agents released by phagocytic host cells during infection. Among them, melanin production is linked to both fungal virulence and defence against h...

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Veröffentlicht in:	Nature microbiology 2024-08, Vol.9 (8), p.2084-2098
Hauptverfasser:	Black, Braydon, da Silva, Leandro Buffoni Roque, Hu, Guanggan, Qu, Xianya, Smith, Daniel F. Q., Magaña, Armando Alcázar, Horianopoulos, Linda C., Caza, Mélissa, Attarian, Rodgoun, Foster, Leonard J., Casadevall, Arturo, Kronstad, James W.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/21 13/31 38/70 38/77 631/208/325 631/326/193/2542 631/326/421 Animal models Animals Biomedical and Life Sciences Cryptococcosis Cryptococcosis - microbiology Cryptococcus neoformans Cryptococcus neoformans - genetics Cryptococcus neoformans - metabolism Cryptococcus neoformans - pathogenicity Disease Models, Animal Drug development Drug metabolism Female Free radicals Gene Expression Regulation, Fungal Glutathione Glutathione - metabolism Homeostasis Infectious Diseases Innate immunity Life Sciences Macrophages Macrophages - immunology Macrophages - metabolism Macrophages - microbiology Medical Microbiology Melanin Melanins - biosynthesis Melanins - metabolism Metabolomics Mice Microbiology Oxidation-Reduction Parasitology Pathogens Phagocytes Virology Virulence
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