Effects of a Hydrolyzed Lignin Derivative on Bleomycin-Induced Pulmonary Fibrosis in Mice
Female C57BL/J mice with pulmonary fibrosis induced by injections of bleomycin (20 mg/kg intraperitoneally, 8 times for 4 weeks) were treated with a lignin derivative-based composition BP-C3 (80 mg/kg, daily intragastric administrations for 4 weeks). Bleomycin treatment increased the severity of pul...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2024-05, Vol.177 (1), p.39-43 |
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| creator | Gubareva, E. A. Golubev, A. G. Semenov, A. L. Yurova, M. N. Kruglov, S. S. Radetskaya, E. A. |
| description | Female C57BL/J mice with pulmonary fibrosis induced by injections of bleomycin (20 mg/kg intraperitoneally, 8 times for 4 weeks) were treated with a lignin derivative-based composition BP-C3 (80 mg/kg, daily intragastric administrations for 4 weeks). Bleomycin treatment increased the severity of pulmonary fibrosis (Ashcroft score increased from 1.43±0.20 to 4.17±0.48) and the percentage of α-SMA
+
tissue (from 15.22±1.01 to 33.12±2.30%) and DNA-synthetizing nuclei (from 1.05±0.14 to 3.38±0.375). After treatment with BP-C3, we observed a tendency to a decrease in Ashcroft score (to 3.40±0.51) and a significant decrease in the percentage of α-SMA
+
tissue to 24.30±1.70%; the percentage of DNA-synthetizing nuclei decreased to a lesser extent (to 3.03±0.22%). These results suggest that BP-C3 has a moderate antifibrotic activity. |
| doi_str_mv | 10.1007/s10517-024-06127-7 |
| format | Article |
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+
tissue (from 15.22±1.01 to 33.12±2.30%) and DNA-synthetizing nuclei (from 1.05±0.14 to 3.38±0.375). After treatment with BP-C3, we observed a tendency to a decrease in Ashcroft score (to 3.40±0.51) and a significant decrease in the percentage of α-SMA
+
tissue to 24.30±1.70%; the percentage of DNA-synthetizing nuclei decreased to a lesser extent (to 3.03±0.22%). These results suggest that BP-C3 has a moderate antifibrotic activity.</description><identifier>ISSN: 0007-4888</identifier><identifier>ISSN: 1573-8221</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-024-06127-7</identifier><identifier>PMID: 38955853</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Antibodies ; Biomedical and Life Sciences ; Biomedicine ; Bleomycin ; Blood vessels ; Cell Biology ; Cell cycle ; Cell growth ; Connective tissue ; Drug dosages ; Extracellular matrix ; Fibrosis ; Internal Medicine ; Laboratory Medicine ; Lignin ; Lung diseases ; Lungs ; Medical research ; Oncology ; Pathology ; Polyphenols ; Pulmonary fibrosis ; Research centers ; Software ; Toxicology</subject><ispartof>Bulletin of experimental biology and medicine, 2024-05, Vol.177 (1), p.39-43</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-efc52d971c53525d60eb06391bdd73d1ee48ee5f3aff07326e2ad9564efe2cad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-024-06127-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-024-06127-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38955853$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gubareva, E. A.</creatorcontrib><creatorcontrib>Golubev, A. G.</creatorcontrib><creatorcontrib>Semenov, A. L.</creatorcontrib><creatorcontrib>Yurova, M. N.</creatorcontrib><creatorcontrib>Kruglov, S. S.</creatorcontrib><creatorcontrib>Radetskaya, E. A.</creatorcontrib><title>Effects of a Hydrolyzed Lignin Derivative on Bleomycin-Induced Pulmonary Fibrosis in Mice</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Female C57BL/J mice with pulmonary fibrosis induced by injections of bleomycin (20 mg/kg intraperitoneally, 8 times for 4 weeks) were treated with a lignin derivative-based composition BP-C3 (80 mg/kg, daily intragastric administrations for 4 weeks). Bleomycin treatment increased the severity of pulmonary fibrosis (Ashcroft score increased from 1.43±0.20 to 4.17±0.48) and the percentage of α-SMA
+
tissue (from 15.22±1.01 to 33.12±2.30%) and DNA-synthetizing nuclei (from 1.05±0.14 to 3.38±0.375). After treatment with BP-C3, we observed a tendency to a decrease in Ashcroft score (to 3.40±0.51) and a significant decrease in the percentage of α-SMA
+
tissue to 24.30±1.70%; the percentage of DNA-synthetizing nuclei decreased to a lesser extent (to 3.03±0.22%). These results suggest that BP-C3 has a moderate antifibrotic activity.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bleomycin</subject><subject>Blood vessels</subject><subject>Cell Biology</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Connective tissue</subject><subject>Drug dosages</subject><subject>Extracellular matrix</subject><subject>Fibrosis</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Lignin</subject><subject>Lung diseases</subject><subject>Lungs</subject><subject>Medical research</subject><subject>Oncology</subject><subject>Pathology</subject><subject>Polyphenols</subject><subject>Pulmonary fibrosis</subject><subject>Research centers</subject><subject>Software</subject><subject>Toxicology</subject><issn>0007-4888</issn><issn>1573-8221</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PXCEUhkljU0fbP-DCkLhxQ8vH5cJdtuPHmEyjC7voityBg8HcCwpzTaa_voxjNXHRFSE878s5D0JHjH5llKpvhVHJFKG8IbRlXBH1Ac2YVIJoztkemtFKkUZrvY8OSrnfXiv4Ce0L3UmppZih3-feg10XnDzu8WLjcho2f8DhZbiLIeIzyOGpX4cnwCniHwOkcWNDJFfRTbZiN9MwptjnDb4Iq5xKKLimfgYLn9FH3w8Fvrych-jXxfntfEGW15dX8-9LYrls1wS8ldx1ilkpJJeupbCirejYyjklHANoNID0oveeKsFb4L3rZNuAB257Jw7R6a73IafHCcrajKFYGIY-QpqKEVRJoVrWyoqevEPv05Rjna5SmupON4JViu8oW_cpGbx5yGGsKxpGzVa82Yk3Vbx5Fm9UDR2_VE-rEdxr5J_pCogdUOpTvIP89vd_av8C_dyN-w</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Gubareva, E. A.</creator><creator>Golubev, A. G.</creator><creator>Semenov, A. L.</creator><creator>Yurova, M. N.</creator><creator>Kruglov, S. S.</creator><creator>Radetskaya, E. A.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20240501</creationdate><title>Effects of a Hydrolyzed Lignin Derivative on Bleomycin-Induced Pulmonary Fibrosis in Mice</title><author>Gubareva, E. A. ; Golubev, A. G. ; Semenov, A. L. ; Yurova, M. N. ; Kruglov, S. S. ; Radetskaya, E. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-efc52d971c53525d60eb06391bdd73d1ee48ee5f3aff07326e2ad9564efe2cad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bleomycin</topic><topic>Blood vessels</topic><topic>Cell Biology</topic><topic>Cell cycle</topic><topic>Cell growth</topic><topic>Connective tissue</topic><topic>Drug dosages</topic><topic>Extracellular matrix</topic><topic>Fibrosis</topic><topic>Internal Medicine</topic><topic>Laboratory Medicine</topic><topic>Lignin</topic><topic>Lung diseases</topic><topic>Lungs</topic><topic>Medical research</topic><topic>Oncology</topic><topic>Pathology</topic><topic>Polyphenols</topic><topic>Pulmonary fibrosis</topic><topic>Research centers</topic><topic>Software</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gubareva, E. A.</creatorcontrib><creatorcontrib>Golubev, A. G.</creatorcontrib><creatorcontrib>Semenov, A. L.</creatorcontrib><creatorcontrib>Yurova, M. N.</creatorcontrib><creatorcontrib>Kruglov, S. S.</creatorcontrib><creatorcontrib>Radetskaya, E. A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gubareva, E. A.</au><au>Golubev, A. G.</au><au>Semenov, A. L.</au><au>Yurova, M. N.</au><au>Kruglov, S. S.</au><au>Radetskaya, E. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of a Hydrolyzed Lignin Derivative on Bleomycin-Induced Pulmonary Fibrosis in Mice</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>177</volume><issue>1</issue><spage>39</spage><epage>43</epage><pages>39-43</pages><issn>0007-4888</issn><issn>1573-8221</issn><eissn>1573-8221</eissn><abstract>Female C57BL/J mice with pulmonary fibrosis induced by injections of bleomycin (20 mg/kg intraperitoneally, 8 times for 4 weeks) were treated with a lignin derivative-based composition BP-C3 (80 mg/kg, daily intragastric administrations for 4 weeks). Bleomycin treatment increased the severity of pulmonary fibrosis (Ashcroft score increased from 1.43±0.20 to 4.17±0.48) and the percentage of α-SMA
+
tissue (from 15.22±1.01 to 33.12±2.30%) and DNA-synthetizing nuclei (from 1.05±0.14 to 3.38±0.375). After treatment with BP-C3, we observed a tendency to a decrease in Ashcroft score (to 3.40±0.51) and a significant decrease in the percentage of α-SMA
+
tissue to 24.30±1.70%; the percentage of DNA-synthetizing nuclei decreased to a lesser extent (to 3.03±0.22%). These results suggest that BP-C3 has a moderate antifibrotic activity.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38955853</pmid><doi>10.1007/s10517-024-06127-7</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Antibodies Biomedical and Life Sciences Biomedicine Bleomycin Blood vessels Cell Biology Cell cycle Cell growth Connective tissue Drug dosages Extracellular matrix Fibrosis Internal Medicine Laboratory Medicine Lignin Lung diseases Lungs Medical research Oncology Pathology Polyphenols Pulmonary fibrosis Research centers Software Toxicology |
| title | Effects of a Hydrolyzed Lignin Derivative on Bleomycin-Induced Pulmonary Fibrosis in Mice |
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